PMID- 34517099
OWN - NLM
STAT- MEDLINE
DCOM- 20220303
LR  - 20220303
IS  - 1873-1708 (Electronic)
IS  - 0890-6238 (Linking)
VI  - 105
DP  - 2021 Oct
TI  - Associations between human internal chemical exposure to Persistent Organic 
      Pollutants (POPs) and In Vitro Fertilization (IVF) outcomes: Systematic review 
      and evidence map of human epidemiological evidence.
PG  - 184-197
LID - S0890-6238(21)00142-8 [pii]
LID - 10.1016/j.reprotox.2021.09.005 [doi]
AB  - The impact of environmental chemicals like persistent organic pollutants (POPs) 
      on reproductive health is still poorly understood, despite the high societal and 
      economical costs. The aim of the present study was to systematically review and 
      evaluate the human evidence on the associations between internal levels of POPs 
      and in vitro Fertilization (IVF) outcomes among women. We applied a protocol 
      based on the National Toxicology Program Office of Health Assessment and 
      Translation's guidelines for the study search, selection and quality assessment. 
      Fifteen studies were finally retained in the present work. The results showed 
      that main families of POPs are still pervasive in follicular fluid and serum of 
      women undergoing IVF treatments. Globally, we found inconsistent findings across 
      studies for specific exposure-outcome dyads, suggesting that adverse effects of 
      POPs on IVF outcomes cannot be ruled out. Specifically, there is evidence that 
      POPs, notably some polychlorinated biphenyls and organochlorine pesticides, may 
      impair embryo quality and pregnancy rates. Most studies have been performed in 
      small cohorts (n<50) and focused on PCBs and OCPs, whereas major research gaps 
      remain for emerging compounds (e.g. perfluoroalkylated substances) and the most 
      clinically relevant outcome, live birth rate. The overall evidence presented 
      'serious' or 'very serious' risk of bias, mainly due to the lack of consideration 
      of relevant confounding variables, low sample size or underreporting of methods. 
      Globally, we judged the level of evidence being "low". Given the high economical 
      and societal costs associated to infertility and IVF, further well-designed 
      research is urged to fill the highlighted gaps.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Lefebvre, Tiphaine
AU  - Lefebvre T
AD  - LABERCA, Oniris, INRAE, 44307, Nantes, France; Department of Biology and 
      Reproductive Medicine, University Hospital of Nantes, Nantes, France; Faculty of 
      Medicine, University of Nantes, Nantes, France.
FAU - Freour, Thomas
AU  - Freour T
AD  - Department of Biology and Reproductive Medicine, University Hospital of Nantes, 
      Nantes, France; Faculty of Medicine, University of Nantes, Nantes, France; Center 
      for Research in Transplantation and Immunology UMR 1064, INSERM, University of 
      Nantes, Nantes, France.
FAU - Ploteau, Stephane
AU  - Ploteau S
AD  - Faculty of Medicine, University of Nantes, Nantes, France; Department of 
      Gynecology and Obstetrics, University Hospital of Nantes, Nantes, France.
FAU - Le Bizec, Bruno
AU  - Le Bizec B
AD  - LABERCA, Oniris, INRAE, 44307, Nantes, France.
FAU - Antignac, Jean-Philippe
AU  - Antignac JP
AD  - LABERCA, Oniris, INRAE, 44307, Nantes, France.
FAU - Cano-Sancho, German
AU  - Cano-Sancho G
AD  - LABERCA, Oniris, INRAE, 44307, Nantes, France. Electronic address: 
      german.cano-sancho@oniris-nantes.fr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20210910
PL  - United States
TA  - Reprod Toxicol
JT  - Reproductive toxicology (Elmsford, N.Y.)
JID - 8803591
SB  - IM
MH  - *Environmental Exposure
MH  - Female
MH  - *Fertilization in Vitro
MH  - Humans
MH  - Persistent Organic Pollutants/*blood
MH  - Pregnancy
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Biomarkers
OT  - Follicular fluid
OT  - In vitro fertilization
OT  - Infertility
OT  - Persistent organic pollutants
OT  - Systematic review
EDAT- 2021/09/14 06:00
MHDA- 2022/03/04 06:00
CRDT- 2021/09/13 20:27
PHST- 2021/02/08 00:00 [received]
PHST- 2021/07/29 00:00 [revised]
PHST- 2021/09/08 00:00 [accepted]
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2022/03/04 06:00 [medline]
PHST- 2021/09/13 20:27 [entrez]
AID - S0890-6238(21)00142-8 [pii]
AID - 10.1016/j.reprotox.2021.09.005 [doi]
PST - ppublish
SO  - Reprod Toxicol. 2021 Oct;105:184-197. doi: 10.1016/j.reprotox.2021.09.005. Epub 
      2021 Sep 10.