PMID- 34517124
OWN - NLM
STAT- MEDLINE
DCOM- 20220322
LR  - 20220322
IS  - 1878-1780 (Electronic)
IS  - 1262-3636 (Linking)
VI  - 47
IP  - 6
DP  - 2021 Nov
TI  - Lower trabecular bone score in type 2 diabetes mellitus: A role for fat mass and 
      insulin resistance beyond hyperglycaemia.
PG  - 101276
LID - S1262-3636(21)00059-8 [pii]
LID - 10.1016/j.diabet.2021.101276 [doi]
AB  - AIMS: To examine the clinical and biochemical determinants of trabecular bone 
      score (TBS) in type 2 diabetes mellitus (T2DM) patients. METHODS: Cross-sectional 
      observational study in 137 T2DM patients (49-85 years). Whole-body fat percentage 
      was estimated using the relative fat mass (RFM) equation. Bone mineral density 
      (BMD) and TBS were assessed using dual-energy X-ray absorptiometry and TBS 
      iNsight Software respectively. RESULTS: T2DM patients showed significantly lower 
      TBS values (P < 0.001) despite significantly higher lumbar spine BMD (LS-BMD) 
      (P = 0.025) compared to controls. TBS values ​​were negatively correlated with 
      body mass index (BMI) (P < 0.001), waist circumference (P < 0.001), and HOMA-2IR 
      index (P = 0.004) and positively correlated with sex hormone-binding globulin 
      (SHBG) (P = 0.01) and LS-BMD (P = 0.003). RFM was negatively associated with TBS 
      in both males (P < 0.001) and females (P = 0.005). The multivariate analysis 
      showed that RFM, HOMA2-IR (negative), SHBG, and LS-BMD (positive) were the 
      variables independently associated with TBS. ROC analysis revealed RFM as the 
      variable with the highest predictive value for risk of degraded bone 
      microarchitecture. CONCLUSIONS: The adiposity estimated by RFM may negatively 
      affect TBS and this relationship may be influenced by insulin resistance and 
      SHBG. RFM could act as a key estimator of degraded bone microarchitecture risk in 
      the T2DM population.
CI  - Copyright (c) 2021 Elsevier Masson SAS. All rights reserved.
FAU - Hayon-Ponce, Maria
AU  - Hayon-Ponce M
AD  - Bone Metabolic Unit, Endocrinology and Nutrition Division. University Hospital 
      Clinico San Cecilio. Av. de la Ilustracion, s/n, 18016, Granada, Spain.
FAU - Garcia-Fontana, Beatriz
AU  - Garcia-Fontana B
AD  - Bone Metabolic Unit, Endocrinology and Nutrition Division. University Hospital 
      Clinico San Cecilio. Av. de la Ilustracion, s/n, 18016, Granada, Spain; Instituto 
      de Investigacion Biosanitaria de Granada (Ibs.GRANADA). Av. Madrid 15, 18012, 
      Granada, Spain; CIBERFES, Instituto de Salud Carlos III. C/ Sinesio Delgado, 4, 
      28029, Madrid, Spain. Electronic address: bgfontana@fibao.es.
FAU - Aviles-Perez, Maria Dolores
AU  - Aviles-Perez MD
AD  - Bone Metabolic Unit, Endocrinology and Nutrition Division. University Hospital 
      Clinico San Cecilio. Av. de la Ilustracion, s/n, 18016, Granada, Spain; Instituto 
      de Investigacion Biosanitaria de Granada (Ibs.GRANADA). Av. Madrid 15, 18012, 
      Granada, Spain; CIBERFES, Instituto de Salud Carlos III. C/ Sinesio Delgado, 4, 
      28029, Madrid, Spain.
FAU - Gonzalez-Salvatierra, Sheila
AU  - Gonzalez-Salvatierra S
AD  - Bone Metabolic Unit, Endocrinology and Nutrition Division. University Hospital 
      Clinico San Cecilio. Av. de la Ilustracion, s/n, 18016, Granada, Spain; Instituto 
      de Investigacion Biosanitaria de Granada (Ibs.GRANADA). Av. Madrid 15, 18012, 
      Granada, Spain; Department of Medicine. University of Granada. Av. de la 
      Investigacion, 11, 18016, Granada, Spain.
FAU - Andujar-Vera, Francisco
AU  - Andujar-Vera F
AD  - Instituto de Investigacion Biosanitaria de Granada (Ibs.GRANADA). Av. Madrid 15, 
      18012, Granada, Spain.
FAU - Moratalla-Aranda, Enrique
AU  - Moratalla-Aranda E
AD  - Instituto de Investigacion Biosanitaria de Granada (Ibs.GRANADA). Av. Madrid 15, 
      18012, Granada, Spain; Department of Nuclear Medicine, University Hospital 
      Clinico San Cecilio. Av. de la Ilustracion, s/n, 18016, Granada, Spain.
FAU - Munoz-Torres, Manuel
AU  - Munoz-Torres M
AD  - Bone Metabolic Unit, Endocrinology and Nutrition Division. University Hospital 
      Clinico San Cecilio. Av. de la Ilustracion, s/n, 18016, Granada, Spain; Instituto 
      de Investigacion Biosanitaria de Granada (Ibs.GRANADA). Av. Madrid 15, 18012, 
      Granada, Spain; CIBERFES, Instituto de Salud Carlos III. C/ Sinesio Delgado, 4, 
      28029, Madrid, Spain; Department of Medicine. University of Granada. Av. de la 
      Investigacion, 11, 18016, Granada, Spain. Electronic address: mmt@mamuto.es.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20210910
PL  - France
TA  - Diabetes Metab
JT  - Diabetes & metabolism
JID - 9607599
SB  - IM
MH  - Absorptiometry, Photon
MH  - Bone Density
MH  - Cancellous Bone/diagnostic imaging
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Female
MH  - Humans
MH  - *Hyperglycemia/complications
MH  - *Insulin Resistance
MH  - Male
OTO - NOTNLM
OT  - Relative fat mass
OT  - SHBG
OT  - Trabecular bone score
OT  - Type 2 diabetes mellitus
COIS- Conflicts of interests None.
EDAT- 2021/09/14 06:00
MHDA- 2022/03/23 06:00
CRDT- 2021/09/13 20:28
PHST- 2021/06/22 00:00 [received]
PHST- 2021/08/20 00:00 [revised]
PHST- 2021/08/26 00:00 [accepted]
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2022/03/23 06:00 [medline]
PHST- 2021/09/13 20:28 [entrez]
AID - S1262-3636(21)00059-8 [pii]
AID - 10.1016/j.diabet.2021.101276 [doi]
PST - ppublish
SO  - Diabetes Metab. 2021 Nov;47(6):101276. doi: 10.1016/j.diabet.2021.101276. Epub 
      2021 Sep 10.