PMID- 34517283
OWN - NLM
STAT- MEDLINE
DCOM- 20220127
LR  - 20240226
IS  - 1950-6007 (Electronic)
IS  - 0753-3322 (Linking)
VI  - 143
DP  - 2021 Nov
TI  - Effects of Polygonatum sibiricum saponin on hyperglycemia, gut microbiota 
      composition and metabolic profiles in type 2 diabetes mice.
PG  - 112155
LID - S0753-3322(21)00939-2 [pii]
LID - 10.1016/j.biopha.2021.112155 [doi]
AB  - Diabetes is a global disease that endangers human health. As reported, saponins 
      are effective bioactive compounds for treating type 2 diabetes mellitus (T2DM) 
      and have nontoxic side effects. This study aimed to examine the hypoglycemic 
      effects of Polygonatum sibiricum saponin (PSS) on T2DM mice. We found that PSS 
      could significantly decrease the levels of insulin secretion and fasting blood 
      glucose (FBG) in T2DM mice. And the level of triacylglycerol (TG), total 
      cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in the blood was 
      decreased. In contrast, the content of high-density lipoprotein cholesterol 
      (HDL-C) was increased. 16S rDNA sequencing was used to evaluate the changes in 
      the gut microbiota of T2DM mice, and metabolites were analyzed by metabolomic 
      profiling. The results showed that PSS could decrease the abundance of Firmicutes 
      in T2DM mice, increase the abundance of Bacteroidetes. It also increased the 
      abundance of some bacterial genera (Lactobacillus, Lachnospiraceae_NK4A136_group 
      and Intestinimonas). The phenotypes of the gut microbiome also changed 
      accordingly. Metabolomics analysis showed that carbohydrate metabolism and amino 
      acid metabolisms, such as L-alanine and L-glutamic acid, were greatly affected by 
      PSS. In addition, the levels of inositol and chlorogenic acid in metabolites also 
      increased significantly under PSS intervention. In general, PSS could exert its 
      hypoglycemic effect, regulate the gut microbiota and affect the metabolism of 
      T2DM mice.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Masson SAS.. All rights 
      reserved.
FAU - Chai, Yangyang
AU  - Chai Y
AD  - School of Forestry, Northeast Forestry University, Harbin 150040, PR China; Key 
      Laboratory of Forest Food Resources Utilization of Heilongjiang Province, Harbin 
      150040, PR China.
FAU - Luo, Jiayuan
AU  - Luo J
AD  - School of Forestry, Northeast Forestry University, Harbin 150040, PR China.
FAU - Bao, Yihong
AU  - Bao Y
AD  - School of Forestry, Northeast Forestry University, Harbin 150040, PR China; Key 
      Laboratory of Forest Food Resources Utilization of Heilongjiang Province, Harbin 
      150040, PR China. Electronic address: baoyihong@163.com.
LA  - eng
PT  - Journal Article
DEP - 20210910
PL  - France
TA  - Biomed Pharmacother
JT  - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
JID - 8213295
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Lipids)
RN  - 0 (Saponins)
SB  - IM
MH  - Animals
MH  - Bacteria/*drug effects/genetics/growth & development
MH  - Biomarkers/blood
MH  - Blood Glucose/*drug effects/metabolism
MH  - Diabetes Mellitus, Experimental/blood/*drug therapy/microbiology
MH  - Diabetes Mellitus, Type 2/blood/*drug therapy/microbiology
MH  - Dysbiosis
MH  - Energy Metabolism/*drug effects
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Hypoglycemic Agents/isolation & purification/*pharmacology
MH  - Lipids/blood
MH  - Male
MH  - Metabolome
MH  - Mice, Inbred ICR
MH  - *Polygonatum/chemistry
MH  - Saponins/isolation & purification/*pharmacology
MH  - Mice
OTO - NOTNLM
OT  - Gut microbiota
OT  - Hypoglycemic
OT  - Metabolism
OT  - Polygonatum sibiricum
OT  - Saponin
OT  - Type 2 diabetes
EDAT- 2021/09/14 06:00
MHDA- 2022/01/28 06:00
CRDT- 2021/09/13 20:36
PHST- 2021/05/06 00:00 [received]
PHST- 2021/08/26 00:00 [revised]
PHST- 2021/08/31 00:00 [accepted]
PHST- 2021/09/14 06:00 [pubmed]
PHST- 2022/01/28 06:00 [medline]
PHST- 2021/09/13 20:36 [entrez]
AID - S0753-3322(21)00939-2 [pii]
AID - 10.1016/j.biopha.2021.112155 [doi]
PST - ppublish
SO  - Biomed Pharmacother. 2021 Nov;143:112155. doi: 10.1016/j.biopha.2021.112155. Epub 
      2021 Sep 10.