PMID- 34517735
OWN - NLM
STAT- Publisher
LR  - 20240220
IS  - 1757-6199 (Electronic)
IS  - 1757-6180 (Linking)
DP  - 2021 Sep 14
TI  - Cytochrome P450 enzymes: a review on drug metabolizing enzyme inhibition studies 
      in drug discovery and development.
LID - 10.4155/bio-2021-0132 [doi]
AB  - Assessment of drug candidate's potential to inhibit cytochrome P450 (CYP) enzymes 
      remains crucial in pharmaceutical drug discovery and development. Both direct and 
      time-dependent inhibition of drug metabolizing CYP enzymes by the concomitant 
      administered drug is the leading cause of drug-drug interactions (DDIs), 
      resulting in the increased toxicity of the victim drug. In this context, 
      pharmaceutical companies have grown increasingly diligent in limiting CYP 
      inhibition liabilities of drug candidates in the early stages and examining risk 
      assessments throughout the drug development process. This review discusses 
      different strategies and decision-making processes for assessing the drug-drug 
      interaction risks by enzyme inhibition and lays particular emphasis on in vitro 
      study designs and interpretation of CYP inhibition data in a stage-appropriate 
      context.
FAU - Rao Gajula, Siva Nageswara
AU  - Rao Gajula SN
AUID- ORCID: 0000-0003-0449-4282
AD  - Department of Pharmaceutical Analysis, National Institute of Pharmaceutical 
      Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 50003, India.
FAU - Pillai, Megha Sajakumar
AU  - Pillai MS
AD  - Department of Pharmaceutical Analysis, National Institute of Pharmaceutical 
      Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 50003, India.
FAU - Samanthula, Gananadhamu
AU  - Samanthula G
AD  - Department of Pharmaceutical Analysis, National Institute of Pharmaceutical 
      Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 50003, India.
FAU - Sonti, Rajesh
AU  - Sonti R
AUID- ORCID: 0000-0001-7631-5605
AD  - Department of Pharmaceutical Analysis, National Institute of Pharmaceutical 
      Education & Research (NIPER), Hyderabad, Balanagar, Telangana, 50003, India.
LA  - eng
PT  - Journal Article
DEP - 20210914
PL  - England
TA  - Bioanalysis
JT  - Bioanalysis
JID - 101512484
SB  - IM
OTO - NOTNLM
OT  - cytochrome P450 enzymes
OT  - direct enzyme inhibition
OT  - drug discovery and development
OT  - drug-drug interactions
OT  - time-dependent enzyme inhibition
EDAT- 2021/09/15 06:00
MHDA- 2021/09/15 06:00
CRDT- 2021/09/14 05:36
PHST- 2021/09/14 05:36 [entrez]
PHST- 2021/09/15 06:00 [pubmed]
PHST- 2021/09/15 06:00 [medline]
AID - 10.4155/bio-2021-0132 [doi]
PST - aheadofprint
SO  - Bioanalysis. 2021 Sep 14. doi: 10.4155/bio-2021-0132.