PMID- 34518471
OWN - NLM
STAT- MEDLINE
DCOM- 20220721
LR  - 20220805
IS  - 1421-9700 (Electronic)
IS  - 1420-3030 (Linking)
VI  - 27
IP  - 4
DP  - 2022
TI  - Audiological Patterns in Patients with Autoimmune Hearing Loss.
PG  - 336-346
LID - 10.1159/000518694 [doi]
AB  - INTRODUCTION: The aim of this study was to illustrate clinical and audiological 
      patterns of hearing impairment in patients with autoimmune hearing loss (AIHL). 
      METHODS: Fifty-three patients with AIHL were retrospectively recruited, and a 
      tapering schema of steroid treatment was administered in all these patients. The 
      diagnosis of AIHL was essentially based on clinical symptoms, such as recurrent, 
      sudden (sensorineural hearing loss [SSHL]), fluctuating, or quickly progressing 
      (<12 months) SSHL (uni-/bilateral), in association with the coexistence of 
      autoimmune diseases, high antinuclear antibodies (ANA) and the presence of human 
      leukocyte antigen (HLA) B27, B35, B51, C04, and C07. Logistic regression analysis 
      was applied to correlate the clinical data and laboratory features of AIHL with 
      final outcomes. RESULTS: The onset of AIHL was mainly progressive (49%), followed 
      by SSHL (39.6%) or fluctuating (11.3%). The pure-tone audiogram showed more 
      commonly a downsloping pattern (42.6% of ears), but also an upsloping, flat, 
      cookie-bite, or inverse cookie-bite shape. Bilateral progressive AIHL was more 
      frequently simultaneous (23 patients) than heterochronous (4 patients). Nineteen 
      patients (35.8%) showed a favorable response to steroid therapy. The presence of 
      recurrent, bilateral SSHL versus recurrent, unilateral SSHL had statistically 
      negative effect on hearing recovery (OR = 0.042, p < 0.05). The heterochronous 
      bilateral SSHL may have better prognosis than simultaneous bilateral SSHL (OR = 
      10.000, p = 0.099). The gender, age, concomitant autoimmune disease, high ANA, 
      HLA alleles, tinnitus, and vestibular symptoms had no statistical effect on a 
      favorable outcome of AIHL. CONCLUSIONS: A bilateral, simultaneous, and 
      progressive hearing loss combined with downsloping audiogram occurred more often 
      in patients with AIHL. Bilateral simultaneous SSHL with recurrences represents 
      the worse prognostic form of AIHL.
CI  - (c) 2021 S. Karger AG, Basel.
FAU - Psillas, George
AU  - Psillas G
AD  - 1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA 
      Hospital, Thessaloniki, Greece.
FAU - Dimas, Grigorios G
AU  - Dimas GG
AD  - 1st Propedeutic Department of Internal Medicine, Aristotle University of 
      Thessaloniki, AHEPA Hospital, Thessaloniki, Greece.
FAU - Daniilidis, Michalis
AU  - Daniilidis M
AD  - 1st Internal Medicine Department, Aristotle University of Thessaloniki, AHEPA 
      Hospital, Thessaloniki, Greece.
FAU - Binos, Paris
AU  - Binos P
AD  - Department of Rehabilitation Sciences, Cyprus University of Technology, Limassol, 
      Cyprus.
FAU - Tegos, Thomas
AU  - Tegos T
AD  - 1st Department of Neurology, Aristotle University of Thessaloniki, AHEPA 
      Hospital, Thessaloniki, Greece.
FAU - Constantinidis, Jiannis
AU  - Constantinidis J
AD  - 1st Academic ENT Department, Aristotle University of Thessaloniki, AHEPA 
      Hospital, Thessaloniki, Greece.
LA  - eng
PT  - Journal Article
DEP - 20210910
PL  - Switzerland
TA  - Audiol Neurootol
JT  - Audiology & neuro-otology
JID - 9606930
RN  - 0 (Steroids)
SB  - IM
MH  - *Deafness/complications
MH  - Hearing Loss, Bilateral/complications
MH  - *Hearing Loss, Sensorineural/complications/diagnosis/drug therapy
MH  - *Hearing Loss, Sudden/complications/diagnosis/drug therapy
MH  - Humans
MH  - Retrospective Studies
MH  - Steroids
MH  - Vertigo
OTO - NOTNLM
OT  - Autoimmune disease
OT  - Fluctuating hearing
OT  - Hearing loss
OT  - Human leukocyte antigen
OT  - Inner ear
OT  - Tone audiometry
EDAT- 2021/09/15 06:00
MHDA- 2022/07/22 06:00
CRDT- 2021/09/14 05:57
PHST- 2020/12/03 00:00 [received]
PHST- 2021/07/26 00:00 [accepted]
PHST- 2021/09/15 06:00 [pubmed]
PHST- 2022/07/22 06:00 [medline]
PHST- 2021/09/14 05:57 [entrez]
AID - 000518694 [pii]
AID - 10.1159/000518694 [doi]
PST - ppublish
SO  - Audiol Neurootol. 2022;27(4):336-346. doi: 10.1159/000518694. Epub 2021 Sep 10.