PMID- 34520085
OWN - NLM
STAT- PubMed-not-MEDLINE
DCOM- 20211014
LR  - 20240403
IS  - 1521-3773 (Electronic)
IS  - 1433-7851 (Print)
IS  - 1433-7851 (Linking)
VI  - 60
IP  - 42
DP  - 2021 Oct 11
TI  - Evaporation-Induced Self-Assembly of Small Peptide-Conjugated Silica 
      Nanoparticles.
PG  - 22700-22705
LID - 10.1002/anie.202108378 [doi]
AB  - Self-assembly processes guide disordered molecules or particles into long-range 
      organized structures due to specific supramolecular interactions among the 
      building entities. Herein, we report a unique evaporation-induced self-assembly 
      (EISA) strategy for four different silica nanoparticle systems obtained through 
      peptide functionalization of the particle surface. First, covalent peptide-silica 
      coupling was investigated in detail, starting with the grafting of a single amino 
      acid (L-serine) and expanded to specific small peptides (up to four amino acids) 
      and transferred to different particle types (MCM-48-type MSNs, solid 
      nanoparticles, and newly developed virus-like nanoparticles). These materials 
      were investigated regarding their ability to undergo EISA, which was shown to be 
      independent of particle type and amount of peptide anchored to their surface. 
      This EISA-based approach provides new possibilities for the design of future 
      advanced drug delivery systems, engineered hierarchical sorbents, and 
      nanocatalyst assemblies.
CI  - (c) 2021 The Authors. Angewandte Chemie International Edition published by 
      Wiley-VCH GmbH.
FAU - von Baeckmann, Cornelia
AU  - von Baeckmann C
AUID- ORCID: 0000-0002-2337-9063
AD  - Department of Inorganic Chemistry-Functional Materials, Faculty of Chemistry, 
      University of Vienna, Wahringer Strasse 42, 1090, Vienna, Austria.
FAU - Rubio, Guilherme M D M
AU  - Rubio GMDM
AUID- ORCID: 0000-0002-6889-0703
AD  - Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, 
      Wahringer Strasse 42, 1090, Vienna, Austria.
FAU - Kahlig, Hanspeter
AU  - Kahlig H
AUID- ORCID: 0000-0002-3898-6501
AD  - Department of Organic Chemistry, Faculty of Chemistry, University of Vienna, 
      Wahringer Strasse 38, 1090, Vienna, Austria.
FAU - Kurzbach, Dennis
AU  - Kurzbach D
AUID- ORCID: 0000-0001-6455-2136
AD  - Department of Biological Chemistry, Faculty of Chemistry, University of Vienna, 
      Wahringer Strasse 38, 1090, Vienna, Austria.
FAU - Reithofer, Michael R
AU  - Reithofer MR
AUID- ORCID: 0000-0002-6328-1896
AD  - Department of Inorganic Chemistry, Faculty of Chemistry, University of Vienna, 
      Wahringer Strasse 42, 1090, Vienna, Austria.
FAU - Kleitz, Freddy
AU  - Kleitz F
AUID- ORCID: 0000-0001-6769-4180
AD  - Department of Inorganic Chemistry-Functional Materials, Faculty of Chemistry, 
      University of Vienna, Wahringer Strasse 42, 1090, Vienna, Austria.
LA  - eng
GR  - University of Vienna/
GR  - P-33338/FWF Der Wissenschaftsfonds/
GR  - 801936/H2020 European Research Council/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210914
PL  - Germany
TA  - Angew Chem Int Ed Engl
JT  - Angewandte Chemie (International ed. in English)
JID - 0370543
SB  - IM
PMC - PMC8519068
OTO - NOTNLM
OT  - EISA
OT  - conjugation
OT  - peptides
OT  - self-organization
OT  - silica nanoparticles
OT  - solid-state NMR
COIS- The authors declare no conflict of interest.
EDAT- 2021/09/15 06:00
MHDA- 2021/09/15 06:01
PMCR- 2021/10/15
CRDT- 2021/09/14 13:27
PHST- 2021/08/01 00:00 [revised]
PHST- 2021/06/23 00:00 [received]
PHST- 2021/09/15 06:00 [pubmed]
PHST- 2021/09/15 06:01 [medline]
PHST- 2021/09/14 13:27 [entrez]
PHST- 2021/10/15 00:00 [pmc-release]
AID - ANIE202108378 [pii]
AID - 10.1002/anie.202108378 [doi]
PST - ppublish
SO  - Angew Chem Int Ed Engl. 2021 Oct 11;60(42):22700-22705. doi: 
      10.1002/anie.202108378. Epub 2021 Sep 14.