PMID- 34520598
OWN - NLM
STAT- MEDLINE
DCOM- 20220224
LR  - 20220224
IS  - 1098-1063 (Electronic)
IS  - 1050-9631 (Linking)
VI  - 31
IP  - 11
DP  - 2021 Nov
TI  - Aberrant slow waves in the hippocampus during activation in mice with low 
      cholinergic tone.
PG  - 1233-1253
LID - 10.1002/hipo.23387 [doi]
AB  - The effects of acetylcholine on cortical activation were studied in wild-type 
      (WT) mice, compared to knockout (KO) mice depleted of the vesicular acetylcholine 
      transporter (VAChT) gene in the basal forebrain, and knockdown (KD) mice with 
      heterogeneous depletion of VAChT gene in the brain. Cortical activation was 
      assessed by comparing power spectra of local field potentials (LFPs) during 
      activated states of rapid-eye-movement sleep (REM) or walk (WLK), with those 
      during non-activated states of slow-wave sleep (SWS) or awake-immobility (IMM). 
      Activation-induced suppression of delta (1-4 Hz) and beta (13-30 Hz) power in the 
      hippocampus, and delta power in frontal cortex, were reduced in KO and KD mice 
      compared to WT mice. Mean theta frequency was higher in KD than KO mice during 
      WLK and REM, but not different between WT and KO mice. Peak theta (4-12 Hz) and 
      integrated gamma (30-150 Hz) power were not significantly different among mouse 
      groups. However, theta-peak-frequency selected gamma2 (62-100 Hz) power was lower 
      in KO than WT or KD mice during WLK, and theta-peak-frequency selected theta 
      power during REM decreased faster with high theta frequency in KO than WT/ KD 
      mice. Theta power increase during REM compared to WLK was lower in KO and KD mice 
      compared to WT mice. Theta-gamma cross-frequency coherence, a measure of 
      synchronization of gamma with theta phase, was not different among mouse groups. 
      However, during REM, SWS, and IMM, delta-gamma coherence was significantly higher 
      and proximal-distal delta coherence in CA1 was lower in KO than WT/KD mice. We 
      conclude that a deficiency in basal forebrain acetylcholine release not only 
      enhances slow waves and suppresses theta-associated gamma waves during 
      activation, but also increases delta-gamma cross-frequency coherence during 
      nonactivated states, with a possible effect of disrupting cognitive processing 
      during any brain state.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Leung, L Stan
AU  - Leung LS
AUID- ORCID: 0000-0001-8887-4869
AD  - Department of Physiology and Pharmacology, University of Western Ontario, London, 
      Ontario, Canada.
AD  - Graduate Program in Neuroscience, University of Western Ontario, London, Ontario, 
      Canada.
FAU - Chu, Liangwei
AU  - Chu L
AD  - Department of Physiology and Pharmacology, University of Western Ontario, London, 
      Ontario, Canada.
LA  - eng
GR  - MOP 136930/CIHR/Canada
GR  - MOP 15685/CIHR/Canada
GR  - MOP 89919/CIHR/Canada
GR  - PJT 159781/CIHR/Canada
GR  - PJT 162431/CIHR/Canada
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210914
PL  - United States
TA  - Hippocampus
JT  - Hippocampus
JID - 9108167
RN  - 0 (Cholinergic Agents)
SB  - IM
MH  - Animals
MH  - Cholinergic Agents
MH  - Electroencephalography
MH  - Hippocampus/physiology
MH  - Mice
MH  - Mice, Knockout
MH  - *Sleep, REM/physiology
MH  - Theta Rhythm/physiology
MH  - *Wakefulness/physiology
OTO - NOTNLM
OT  - delta waves
OT  - delta-gamma coupling
OT  - rapid-eye-movement sleep
OT  - slow-wave sleep
OT  - theta rhythm
OT  - theta-gamma coupling
OT  - vesicular acetylcholine transporter
EDAT- 2021/09/15 06:00
MHDA- 2022/02/25 06:00
CRDT- 2021/09/14 17:32
PHST- 2021/08/19 00:00 [revised]
PHST- 2021/06/10 00:00 [received]
PHST- 2021/08/28 00:00 [accepted]
PHST- 2021/09/15 06:00 [pubmed]
PHST- 2022/02/25 06:00 [medline]
PHST- 2021/09/14 17:32 [entrez]
AID - 10.1002/hipo.23387 [doi]
PST - ppublish
SO  - Hippocampus. 2021 Nov;31(11):1233-1253. doi: 10.1002/hipo.23387. Epub 2021 Sep 
      14.