PMID- 34520837 OWN - NLM STAT- MEDLINE DCOM- 20220519 LR - 20220610 IS - 1878-1780 (Electronic) IS - 1262-3636 (Linking) VI - 48 IP - 3 DP - 2022 May TI - Overweight and risk of type 2 diabetes: A prospective Chinese twin study. PG - 101278 LID - S1262-3636(21)00061-6 [pii] LID - 10.1016/j.diabet.2021.101278 [doi] AB - OBJECTIVES: This study aimed to estimate the association between overweight and type 2 diabetes mellitus (T2DM) in twins, and further to explore whether genetic and early-life environmental factors account for this association. METHODS: This study included 31,197 twin individuals from the Chinese National Twin Registry (CNTR). Generalized estimating equation (GEE) models were applied for unmatched case-control analysis. Conditional logistic regressions were used in co-twin matched case-control analysis. Logistic regressions were fitted to examine the differences in odds ratios (ORs) from the GEE models and conditional logistic regressions. Bivariate genetic model was used to explore the genetic and environmental correlation between body mass index (BMI) and T2DM. RESULTS: In the GEE model, overweight was associated with a higher T2DM risk (OR=2.71, 95% confidence interval (CI): 1.96 approximately 3.73), compared with participants with normal BMI. In the multi-adjusted conditional logistic regression, the association was still significant (OR=2.60, 95% CI: 1.15 approximately 5.87). The ORs from the unmatched and matched analyses were different (P = 0.042). Particularly, overweight could increase T2DM risk in monozygotic (MZ) twins, and the difference in ORs between the unmatched and matched designs was significant (P = 0.014). After controlling for age and sex, the positive BMI-T2DM association was partly due to a significant genetic correlation (rA= 0.31, 95% CI: 0.20 approximately 0.41). CONCLUSIONS: Our findings suggest that genetics and early-life environments might account for the observed overweight-T2DM association. Genetic correlation between BMI and T2DM further provides evidence for the influence of overlap genes on their association. CI - Copyright (c) 2021 Elsevier Masson SAS. All rights reserved. FAU - Xi, Yu'e AU - Xi Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Gao, Wenjing AU - Gao W AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. Electronic address: pkuepigwj@126.com. FAU - Zheng, Ke AU - Zheng K AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Lv, Jun AU - Lv J AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Yu, Canqing AU - Yu C AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Wang, Shengfeng AU - Wang S AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Huang, Tao AU - Huang T AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Sun, Dianjianyi AU - Sun D AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Liao, Chunxiao AU - Liao C AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Pang, Yuanjie AU - Pang Y AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. FAU - Pang, Zengchang AU - Pang Z AD - Qingdao Municipal Center for Disease Control and Prevention, Qingdao 266033, China. FAU - Yu, Min AU - Yu M AD - Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China. FAU - Wang, Hua AU - Wang H AD - Jiangsu Provincial Center for Disease Control and Prevention, Nanjing 210009, China. FAU - Wu, Xianping AU - Wu X AD - Sichuan Center for Disease Control and Prevention, Chengdu 610041, China. FAU - Dong, Zhong AU - Dong Z AD - Beijing Center for Disease Prevention and Control, Beijing 100013, China. FAU - Wu, Fan AU - Wu F AD - Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China. FAU - Jiang, Guohong AU - Jiang G AD - Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China. FAU - Wang, Xiaojie AU - Wang X AD - Qinghai Center for Diseases Prevention and Control, Xining 810007, China. FAU - Liu, Yu AU - Liu Y AD - Heilongjiang Provincial Center for Disease Control and Prevention, Harbin 150030, China. FAU - Deng, Jian AU - Deng J AD - Handan Center for Disease Control and Prevention, Handan 056001, China. FAU - Lu, Lin AU - Lu L AD - Yunnan Center for Disease Control and Prevention, Kunming 650034, China. FAU - Cao, Weihua AU - Cao W AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. Electronic address: caoweihua60@163.com. FAU - Li, Liming AU - Li L AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China. LA - eng PT - Journal Article PT - Twin Study DEP - 20210912 PL - France TA - Diabetes Metab JT - Diabetes & metabolism JID - 9607599 SB - IM MH - Body Mass Index MH - China/epidemiology MH - *Diabetes Mellitus, Type 2/complications/epidemiology/genetics MH - Humans MH - Obesity/complications MH - *Overweight/complications/epidemiology/genetics MH - Prospective Studies OTO - NOTNLM OT - Genetic correlation OT - Overweight OT - Twin study OT - Type 2 diabetes COIS- Declaration of competing Interest The authors have no conflicts of interest to declare. EDAT- 2021/09/15 06:00 MHDA- 2022/05/20 06:00 CRDT- 2021/09/14 20:13 PHST- 2021/05/11 00:00 [received] PHST- 2021/08/04 00:00 [revised] PHST- 2021/08/07 00:00 [accepted] PHST- 2021/09/15 06:00 [pubmed] PHST- 2022/05/20 06:00 [medline] PHST- 2021/09/14 20:13 [entrez] AID - S1262-3636(21)00061-6 [pii] AID - 10.1016/j.diabet.2021.101278 [doi] PST - ppublish SO - Diabetes Metab. 2022 May;48(3):101278. doi: 10.1016/j.diabet.2021.101278. Epub 2021 Sep 12.