PMID- 34521168
OWN - NLM
STAT- MEDLINE
DCOM- 20210916
LR  - 20210916
IS  - 1673-0860 (Print)
IS  - 1673-0860 (Linking)
VI  - 56
IP  - 8
DP  - 2021 Aug 7
TI  - [Prognostic value of the age-adjusted Charlson comorbidity index in patients over 
      60 years old with laryngeal squamous cell carcinoma].
PG  - 837-843
LID - 10.3760/cma.j.cn115330-20201124-00890 [doi]
AB  - Objective: To evaluate the value of the age-adjusted Charlson comorbidity Index 
      (ACCI) in predicting the prognosis and guiding the clinical treatment of 
      laryngeal squamous cell carcinoma (LSCC) in patients over 60 years old. Methods: 
      Retrospective analysis of 249 cases of LSCC in Shanxi Provincial Cancer Hospital 
      and First Hospital of Shanxi Medical University from 2008 to 2015 was performed. 
      There were 234 males and 15 females, aged from 60 to 88 years. The clinical 
      characteristics, treatment information and follow-up data were collected. ACCI 
      was used to score the comorbidities of the patients. Receiver operating 
      characteristic (ROC) curve was drawn and the patients were divided into high ACCI 
      group and low ACCI group according to the cut-off value of ACCI. Prognostic 
      factors were analyzed. Kaplan-Meier method was used for survival analysis, rank 
      sum test was used for comparison between groups, chi(2) test was used for 
      enumeration data. Results: Overall survival (OS) was 54.6%, progression-free 
      survival (PFS) was 59.4%, and cancer-specific survival (CSS) was 58.6%. Both the 
      median survival time and PFS time were 60 months. The best cutoff point of the 
      ACCI group was 5. Cox multivariate analysis showed that ACCI was an independent 
      risk factor for OS, PFS and CSS (OR=1.553, 1.499 and 1.534,respectively, all 
      P<0.05). In the high ACCI group, OS (chi(2)=4.120 and 4.115,P<0.05) and CSS 
      (chi(2)=4.510 and 5.009,P<0.05) of patients treated with surgery plus radiotherapy 
      and patients with radiotherapy alone were better than those of patients with 
      surgery alone (P<0.05). But in the low ACCI group, there was no significant 
      difference in prognosis among the three treatment regimens (P>0.05). Conclusion: 
      High ACCI offors important prognostic information for LSCC in patients over 60 
      years old, and can guide clinical treatment options.
FAU - Li, Z L
AU  - Li ZL
AD  - Department of Head and Neck Surgery, Shanxi Provincial Cancer Hospital, Taiyuan 
      030013, China.
FAU - An, C M
AU  - An CM
AD  - Department of Head and Neck Surgery, National Cancer Center/National Clinical 
      Research Center for Caner/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing 100021, China.
FAU - Gao, Z H
AU  - Gao ZH
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, First Hospital of 
      Shanxi Medical University, Taiyuan 030012, China.
FAU - Cao, J Z
AU  - Cao JZ
AD  - Department of Head and Neck Surgery, Shanxi Provincial Cancer Hospital, Taiyuan 
      030013, China.
FAU - Huangfu, H
AU  - Huangfu H
AD  - Department of Otorhinolaryngology, Head and Neck Surgery, First Hospital of 
      Shanxi Medical University, Taiyuan 030012, China.
FAU - Nan, J
AU  - Nan J
AD  - Department of Head and Neck Surgery, Shanxi Provincial Cancer Hospital, Taiyuan 
      030013, China.
FAU - Zhu, B Y
AU  - Zhu BY
AD  - Department of Head and Neck Surgery, Shanxi Provincial Cancer Hospital, Taiyuan 
      030013, China.
FAU - Zhang, Y
AU  - Zhang Y
AD  - Department of Radiation Oncology, National Cancer Center/National Clinical 
      Research Center for Caner/Cancer Hospital, Chinese Academy of Medical Sciences 
      and Peking Union Medical College, Beijing 100021, China.
LA  - chi
PT  - Journal Article
PL  - China
TA  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi
JT  - Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of 
      otorhinolaryngology head and neck surgery
JID - 101247574
SB  - IM
MH  - Age Factors
MH  - Comorbidity
MH  - Female
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Prognosis
MH  - Retrospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck
EDAT- 2021/09/16 06:00
MHDA- 2021/09/18 06:00
CRDT- 2021/09/15 01:19
PHST- 2021/09/15 01:19 [entrez]
PHST- 2021/09/16 06:00 [pubmed]
PHST- 2021/09/18 06:00 [medline]
AID - 10.3760/cma.j.cn115330-20201124-00890 [doi]
PST - ppublish
SO  - Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Aug 7;56(8):837-843. doi: 
      10.3760/cma.j.cn115330-20201124-00890.