PMID- 34522606
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220426
IS  - 2213-4220 (Print)
IS  - 2213-4239 (Electronic)
IS  - 2213-4220 (Linking)
VI  - 11
IP  - 1
DP  - 2022 Mar
TI  - Compound glycyrrhizin injection for improving liver function in children with 
      acute icteric hepatitis: A systematic review and meta-analysis.
PG  - 100772
LID - 10.1016/j.imr.2021.100772 [doi]
LID - 100772
AB  - BACKGROUND: Compound glycyrrhizin injection (CGI) is a preparation with 
      glycyrrhizin as the main active ingredient extracted from licorice. As clinical 
      trials suggest that CGI is effective in improving liver function for acute 
      icteric hepatitis in children (AIHC), this systematic review aimed to evaluate 
      and verify its therapeutic effects and safety. METHODS: Six electronic databases 
      were searched from their inception to 15 May 2021. Randomized controlled trials 
      (RCTs) assessing therapeutic effects and safety of CGI for AIHC were included. 
      The risk of bias for each trial was assessed using the Cochrane Risk of Bias Tool 
      2.0. Primary outcomes were indexes related to liver function, including total 
      bilirubin (TBiL), alanine aminotransferase (ALT) and aspartate transaminase 
      (AST). RevMan 5.4 software was used for data analyses. The certainty of the 
      evidence was assessed using the online GRADEpro tool. RESULTS: Six RCTs involving 
      608 children were included. The overall bias was assessed as having "high risk of 
      bias" in all trials. All trials compared the combination of CGI and conventional 
      western medicine (CWM) with CWM alone. Regarding the effects of CGI for AIHC, 
      results showed that CGI plus CWM was superior to CWM alone in reducing the levels 
      of TBiL (mean difference (MD) = -8.19 mmol/L, 95% CI -9.86 to -6.53), ALT 
      (MD = -24.09 U/L, 95% CI -30.83 to -17.34) and AST (MD = -18.67 U/L, 95% CI 
      -21.88 to -15.45). No trial reported adverse events. The certainty of the 
      evidence for outcomes were all evaluated as low or very low. CONCLUSION: CGI may 
      have adjuvant therapeutic effects on improving the liver function of children 
      with AIHC. There is no evidence to determine the safety of CGI for AIHC. As 
      current evidence is weak, further well-designed RCTs are required for 
      verification of the therapeutic effects of CGI.
CI  - (c) 2021 Korea Institute of Oriental Medicine. Published by Elsevier B.V.
FAU - Liang, Shi-Bing
AU  - Liang SB
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Hou, Wen-Bin
AU  - Hou WB
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Zheng, Ruo-Xiang
AU  - Zheng RX
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Liang, Chang-Hao
AU  - Liang CH
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Yan, Li-Jiao
AU  - Yan LJ
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Wang, Hao-Nan
AU  - Wang HN
AD  - School of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 
      China.
FAU - Cao, Hui-Juan
AU  - Cao HJ
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Han, Mei
AU  - Han M
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Robinson, Nicola
AU  - Robinson N
AD  - Institute of Health and Social Care, London South Bank University, London, UK.
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
FAU - Liu, Jian-Ping
AU  - Liu JP
AD  - Centre for Evidence-Based Chinese Medicine, Beijing University of Chinese 
      Medicine, Beijing, China.
AD  - Institute of Integrated Traditional Chinese Medicine and Western Medicine, 
      Guangzhou Medical University, Guangzhou, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210821
PL  - Netherlands
TA  - Integr Med Res
JT  - Integrative medicine research
JID - 101612707
PMC - PMC8426202
OTO - NOTNLM
OT  - Acute icteric hepatitis
OT  - Glycyrrhizin
OT  - Liver function
OT  - Randomized trials
OT  - Systematic review
EDAT- 2021/09/16 06:00
MHDA- 2021/09/16 06:01
PMCR- 2021/08/21
CRDT- 2021/09/15 07:17
PHST- 2021/01/07 00:00 [received]
PHST- 2021/07/02 00:00 [revised]
PHST- 2021/08/04 00:00 [accepted]
PHST- 2021/09/15 07:17 [entrez]
PHST- 2021/09/16 06:00 [pubmed]
PHST- 2021/09/16 06:01 [medline]
PHST- 2021/08/21 00:00 [pmc-release]
AID - S2213-4220(21)00059-7 [pii]
AID - 100772 [pii]
AID - 10.1016/j.imr.2021.100772 [doi]
PST - ppublish
SO  - Integr Med Res. 2022 Mar;11(1):100772. doi: 10.1016/j.imr.2021.100772. Epub 2021 
      Aug 21.