PMID- 34522931
OWN - NLM
STAT- MEDLINE
DCOM- 20220131
LR  - 20220131
IS  - 2042-650X (Electronic)
IS  - 2042-6496 (Linking)
VI  - 12
IP  - 20
DP  - 2021 Oct 19
TI  - Flavonoids from Rosa davurica Pall. fruits prevent high-fat diet-induced obesity 
      and liver injury via modulation of the gut microbiota in mice.
PG  - 10097-10106
LID - 10.1039/d1fo01373d [doi]
AB  - Rosa davurica Pall. (RDP) fruits are popularly consumed as beverages and healthy 
      food in China because of their various beneficial activities. In particular, 
      flavonoids are one of the major active ingredients of RDP fruits with predominant 
      pharmacological effects. However, the anti-obesity activities of flavonoids from 
      RDP fruits and their regulation effect on the gut microbiota have not been 
      determined. In the present study, the flavonoid-rich extracts (RDPF) were 
      isolated from RDP fruits and their anti-obesity effects were investigated using a 
      high-fat diet (HFD)-induced obese mouse model. The results showed that RDPF 
      intervention significantly inhibited the body weight, liver weight, kidney weight 
      and epididymal adipose tissue weight of HFD-fed mice without affecting the 
      calorie intake. Plasma lipid levels were also significantly lowered by RDPF 
      treatment. Histological examination showed that RDPF supplementation partially 
      recovered HFD-induced hepatic steatosis in the liver. RDPF also prevented 
      oxidative injury of the liver, as evidenced by the altered superoxide dismutase 
      (SOD), catalase (CAT) and malondialdehyde (MDA) levels. The expression levels of 
      CCAAT/enhancer binding protein alpha (C/EBPalpha), sterol regulatory element binding 
      protein-1C (SREBP-1C), fatty acid synthase (FAS), acyl-coenzyme A oxidase 1 
      (ACOX1), peroxisome proliferator-activated receptor (PPARalpha) and CAT mRNA in the 
      livers of mice were also regulated by RDPF administration. 16S rRNA gene sequence 
      data further indicated that RDPF addition increased the microbial diversity and 
      reshaped the community composition. Intriguingly, RDPF intervention did not 
      exhibit inhibitory tendency toward the ratio of Firmicutes to Bacteroidetes, but 
      markedly decreased the relative abundance of Erysipelotrichaceae. This study 
      provided novel insights into the application of RDPF in the food industry.
FAU - Shen, Chun-Yan
AU  - Shen CY
AD  - College of Food and Bioengineering, South China University of Technology, 
      Guangzhou, 510640, China. jgjiang@scut.edu.cn.
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 
      510515, China.
FAU - Hao, Yun-Fang
AU  - Hao YF
AD  - College of Food and Bioengineering, South China University of Technology, 
      Guangzhou, 510640, China. jgjiang@scut.edu.cn.
FAU - Hao, Zhan-Xi
AU  - Hao ZX
AD  - College of Food and Bioengineering, South China University of Technology, 
      Guangzhou, 510640, China. jgjiang@scut.edu.cn.
FAU - Liu, Qiang
AU  - Liu Q
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 
      510515, China.
FAU - Zhang, Lu
AU  - Zhang L
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 
      510515, China.
FAU - Jiang, Cui-Ping
AU  - Jiang CP
AD  - School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 
      510515, China.
FAU - Jiang, Jian-Guo
AU  - Jiang JG
AUID- ORCID: 0000-0002-3361-6149
AD  - College of Food and Bioengineering, South China University of Technology, 
      Guangzhou, 510640, China. jgjiang@scut.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20211019
PL  - England
TA  - Food Funct
JT  - Food & function
JID - 101549033
RN  - 0 (Anti-Obesity Agents)
RN  - 0 (CCAAT-Enhancer-Binding Protein-alpha)
RN  - 0 (Flavonoids)
RN  - 0 (Lipids)
RN  - 0 (PPAR alpha)
RN  - 0 (RNA, Ribosomal, 16S)
RN  - 0 (Sterol Regulatory Element Binding Protein 1)
SB  - IM
MH  - Adipose Tissue/metabolism
MH  - Animals
MH  - Anti-Obesity Agents/pharmacology
MH  - CCAAT-Enhancer-Binding Protein-alpha/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Fatty Liver/*drug therapy/metabolism
MH  - Flavonoids/*pharmacology
MH  - Fruit/chemistry
MH  - Gastrointestinal Microbiome/*drug effects
MH  - Lipids/blood
MH  - Liver/metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - Obesity/*drug therapy/metabolism
MH  - PPAR alpha/metabolism
MH  - RNA, Ribosomal, 16S/metabolism
MH  - Rosa/*chemistry
MH  - Sterol Regulatory Element Binding Protein 1/metabolism
EDAT- 2021/09/16 06:00
MHDA- 2022/02/01 06:00
CRDT- 2021/09/15 07:23
PHST- 2021/09/16 06:00 [pubmed]
PHST- 2022/02/01 06:00 [medline]
PHST- 2021/09/15 07:23 [entrez]
AID - 10.1039/d1fo01373d [doi]
PST - epublish
SO  - Food Funct. 2021 Oct 19;12(20):10097-10106. doi: 10.1039/d1fo01373d.