PMID- 34523591
OWN - NLM
STAT- MEDLINE
DCOM- 20220103
LR  - 20220103
IS  - 1308-4488 (Electronic)
IS  - 1016-5169 (Linking)
VI  - 49
IP  - 6
DP  - 2021 Sep
TI  - Differences in autoimmunity factors based on the activity of thromboangiitis 
      obliterans.
PG  - 439-447
LID - 10.5543/tkda.2021.19014 [doi]
AB  - OBJECTIVE: The treatment of Buerger's disease (BD) presents a medical problem as 
      its etiology is still unclear. In this study, our objective was to evaluate the 
      serum levels of autoimmune markers in patients with different clinical features 
      of BD. METHODS: In this study, 80 BD patients were categorized in three groups 
      using a cross-sectional design: migratory thrombophlebitis, cold sensitivity, and 
      skin discoloration (mild symptoms); chronic ulcers, claudication, and burning 
      pain of the feet at night (moderate symptoms); pain at rest and spontaneous 
      gangrene (severe symptoms). Enzyme-linked immunosorbent assay was performed to 
      measure antibodies against immunoglobulin M rheumatoid factor (IgM RF), 
      anti-nuclear antibodies (ANA), antibodies against cyclic citrullinated peptide 
      (anti-CCP), antiphospholipid antibodies (APA), anti-cardiolipin antibodies 
      (ACLA), anti-double stranded DNA (anti-dsDNA), and extractable nuclear antigen 
      (ENA) profile. RESULTS: Patients with severe symptoms showed the lowest age 
      (p=0.031), ESR (p<0.001), and highest prevalence of ischemia (p<0.001). In all 
      the patients, the serum levels of ANA and IgM RF were higher than 1 U and 15 
      IU/mL, respectively. However, the progression of the disease from mild to 
      moderate did not affect these markers significantly (p>0.05). Other markers were 
      negative in patients with BD. CONCLUSION: The findings of this study indicate 
      that BD may closely be correlated to transient autoimmune phenomena, despite the 
      fact that further research is required to investigate how transient unspecific 
      autoimmune reactions contribute to the BD pathogenesis.
FAU - Shapouri-Moghadam, Abbas
AU  - Shapouri-Moghadam A
AD  - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Afshari, Seyed Jalil Tavakkol
AU  - Afshari SJT
AD  - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Modaghegh, Mohammad-Hadi Saeed
AU  - Modaghegh MS
AD  - Vascular and Endovascular Surgery Research Center, Alavi Hospital, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Mahmoudi, Mahmoud
AU  - Mahmoudi M
AD  - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
FAU - Rahimi, Hamid Reza
AU  - Rahimi HR
AD  - Department of Medical Genetics and Molecular Medicine, Faculty of Medicine, 
      Mashhad University of Medical Sciences, Mashhad, Iran.
FAU - Ehteshamfar, Seyed Morteza
AU  - Ehteshamfar SM
AD  - Immunology Research Center, Mashhad University of Medical Sciences, Mashhad, 
      Iran.
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk Kardiyol Dern Ars
JT  - Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir
JID - 9426239
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Biomarkers)
RN  - 9009-79-4 (Rheumatoid Factor)
SB  - IM
MH  - Adult
MH  - Antibodies, Antinuclear/*blood
MH  - Autoimmunity
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Rheumatoid Factor/*blood/immunology
MH  - Thromboangiitis Obliterans/*blood
EDAT- 2021/09/16 06:00
MHDA- 2022/01/04 06:00
CRDT- 2021/09/15 08:48
PHST- 2021/09/15 08:48 [entrez]
PHST- 2021/09/16 06:00 [pubmed]
PHST- 2022/01/04 06:00 [medline]
AID - 10.5543/tkda.2021.19014 [doi]
PST - ppublish
SO  - Turk Kardiyol Dern Ars. 2021 Sep;49(6):439-447. doi: 10.5543/tkda.2021.19014.