PMID- 34524590
OWN - NLM
STAT- MEDLINE
DCOM- 20230127
LR  - 20230202
IS  - 1563-258X (Electronic)
IS  - 0043-5341 (Print)
IS  - 0043-5341 (Linking)
VI  - 173
IP  - 1-2
DP  - 2023 Feb
TI  - Hashimoto's thyroiditis and coexisting disorders in correlation with HLA 
      status-an overview.
PG  - 41-53
LID - 10.1007/s10354-021-00879-x [doi]
AB  - Hashimoto's thyroiditis (HT), also known as chronic lymphocytic thyroiditis, is 
      a frequent disorder of the thyroid gland caused by autoimmune-trigged lymphocytic 
      infiltration and destruction of the thyroid gland. With the progressive 
      destruction of the organ, the thyroid gland shrinks in size, thus commonly 
      leading to hypothyroidism. Therapy of HT is mainly focused on managing the 
      thyroid dysfunction by oral substitution of L‑thyroxine. However, patients with 
      HT often complain about a broad spectrum of symptoms, with some of them hardly 
      explained by HT itself. Several other disorders are known to be associated with 
      HT. The etiology of HT seems to be multifactorial, including environmental 
      influences such as iodine supply, infections, and stress as triggers of immune 
      modulation. In addition, also a genetic background based on changes of the human 
      leukocyte antigen (HLA) status seems to be evident. The paper will provide an 
      overview of diseases related to HT, including their correlation to certain HLA 
      patterns. This presentation should give a broader view on HT-related disorders 
      and facilitate detailed examination and management of patients with HT.
CI  - (c) 2021. The Author(s).
FAU - Mikosch, Peter
AU  - Mikosch P
AUID- ORCID: 0000-0001-7181-9062
AD  - Teaching Unit, Medizinische Universitat Wien/Medical University Vienna, Vienna, 
      Austria. peter.mikosch@meduniwien.ac.at.
AD  - Dept. Internal Medicinie 2, Landesklinikum Mistelbach-Ganserndorf, 
      Liechtensteinstrasse 67, 2130, Mistelbach, Austria. 
      peter.mikosch@meduniwien.ac.at.
FAU - Aistleitner, Adrian
AU  - Aistleitner A
AD  - Teaching Unit, Medizinische Universitat Wien/Medical University Vienna, Vienna, 
      Austria.
FAU - Oehrlein, Markus
AU  - Oehrlein M
AD  - Teaching Unit, Medizinische Universitat Wien/Medical University Vienna, Vienna, 
      Austria.
FAU - Trifina-Mikosch, Eva
AU  - Trifina-Mikosch E
AD  - Teaching Unit, Medizinische Universitat Wien/Medical University Vienna, Vienna, 
      Austria.
LA  - eng
PT  - Journal Article
PT  - Review
TT  - Hashimoto-Thyreoiditis und assoziierte Erkrankungen in Korrelation zum 
      HLA-Status - eine Ubersicht.
DEP - 20210915
PL  - Austria
TA  - Wien Med Wochenschr
JT  - Wiener medizinische Wochenschrift (1946)
JID - 8708475
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Humans
MH  - *Hashimoto Disease/diagnosis/genetics
MH  - *Hypothyroidism/diagnosis
MH  - HLA Antigens
PMC - PMC9877058
OTO - NOTNLM
OT  - Autoimmune disorders
OT  - Comorbidity
OT  - Diagnostics
OT  - Genetics
OT  - Thyroid
COIS- P. Mikosch, A. Aistleitner, M. Oehrlein, and E. Trifina-Mikosch declare that they 
      have no competing interests.
EDAT- 2021/09/16 06:00
MHDA- 2023/01/28 06:00
PMCR- 2021/09/15
CRDT- 2021/09/15 12:46
PHST- 2021/02/18 00:00 [received]
PHST- 2021/07/02 00:00 [accepted]
PHST- 2021/09/16 06:00 [pubmed]
PHST- 2023/01/28 06:00 [medline]
PHST- 2021/09/15 12:46 [entrez]
PHST- 2021/09/15 00:00 [pmc-release]
AID - 10.1007/s10354-021-00879-x [pii]
AID - 879 [pii]
AID - 10.1007/s10354-021-00879-x [doi]
PST - ppublish
SO  - Wien Med Wochenschr. 2023 Feb;173(1-2):41-53. doi: 10.1007/s10354-021-00879-x. 
      Epub 2021 Sep 15.