PMID- 34525949 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240403 IS - 1865-1372 (Print) IS - 1865-1380 (Electronic) IS - 1865-1372 (Linking) VI - 14 IP - 1 DP - 2021 Sep 15 TI - Recurrent acute pancreatitis during a ketogenic diet-a case report and literature review. PG - 52 LID - 10.1186/s12245-021-00374-5 [doi] LID - 52 AB - BACKGROUND: The ketogenic ("keto") diet has been gaining more attention lately in the medical literature and the lay media as a potentially effective method for weight control and management of type 2 diabetes. Though rare, there have been case reports of serious side effects. Here, we present a peculiar case of pancreatitis presumably associated with the ketogenic diet. CASE PRESENTATION: A 35-year-old man on a calorie-restricted ketogenic diet presented to the emergency department with weekly abdominal pain on Monday mornings, each time after dietary indiscretions ("cheat days") on the weekend. It was found that he had a clinical presentation consistent with acute pancreatitis with no associated alcohol use, hypertriglyceridemia, pancreatic obstruction, or other anatomic abnormalities. The patient's symptoms resolved with conservative management and progressive reintroduction of a standard diet. CONCLUSION: This case indicates that the ketogenic diet could lower the threshold for acute pancreatitis, and that an episodic stressor may trigger an acute attack in the absence of traditional risk factors. CI - (c) 2021. The Author(s). FAU - Choi, Joseph AU - Choi J AUID- ORCID: 0000-0002-5815-9431 AD - Emergency Department, University Health Network, 200 Elizabeth Street, RFE - Ground Floor, 480, Toronto, Ontario, M5G 2C4, Canada. joseph.choi@utoronto.ca. AD - Division of Emergency Medicine, Department of Medicine, University of Toronto, C. David Naylor Building, 6 Queen's Park Crescent West, Third Floor, Toronto, Ontario, M5S 3H2, Canada. joseph.choi@utoronto.ca. FAU - Young, Tayler L AU - Young TL AD - Faculty of Medicine, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada. FAU - Chartier, Lucas B AU - Chartier LB AD - Emergency Department, University Health Network, 200 Elizabeth Street, RFE - Ground Floor, 480, Toronto, Ontario, M5G 2C4, Canada. AD - Division of Emergency Medicine, Department of Medicine, University of Toronto, C. David Naylor Building, 6 Queen's Park Crescent West, Third Floor, Toronto, Ontario, M5S 3H2, Canada. LA - eng PT - Journal Article DEP - 20210915 PL - England TA - Int J Emerg Med JT - International journal of emergency medicine JID - 101469435 PMC - PMC8444592 OTO - NOTNLM OT - Emergency department OT - Gastroenterology OT - Ketogenic diet OT - Low carbohydrate diet OT - Pancreatitis COIS- The authors declare that they have no competing interests. EDAT- 2021/09/17 06:00 MHDA- 2021/09/17 06:01 PMCR- 2021/09/15 CRDT- 2021/09/16 05:40 PHST- 2021/07/25 00:00 [received] PHST- 2021/08/27 00:00 [accepted] PHST- 2021/09/16 05:40 [entrez] PHST- 2021/09/17 06:00 [pubmed] PHST- 2021/09/17 06:01 [medline] PHST- 2021/09/15 00:00 [pmc-release] AID - 10.1186/s12245-021-00374-5 [pii] AID - 374 [pii] AID - 10.1186/s12245-021-00374-5 [doi] PST - epublish SO - Int J Emerg Med. 2021 Sep 15;14(1):52. doi: 10.1186/s12245-021-00374-5.