PMID- 34526751
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 0976-7800 (Print)
IS  - 0976-7819 (Electronic)
IS  - 0976-7800 (Linking)
VI  - 12
IP  - 2
DP  - 2021 Apr-Jun
TI  - Sex Hormone-Binding Globulins and Testosterone Levels as a Risk Marker for Type 2 
      Diabetes Mellitus among Postmenopausal Women.
PG  - 155-160
LID - 10.4103/jmh.JMH_142_20 [doi]
AB  - BACKGROUND: Endogenous sex hormones and sex hormone-binding globulins (SHBG) 
      determine the risk of occurrence of Type 2 diabetes mellitus (T2DM) in 
      postmenopausal (PM) women. AIMS: To investigate the association between sex 
      hormones (estradiol and testosterone) and SHBG with plasma glucose, fasting 
      insulin levels, HbA1c, and homeostasis model assessment insulin resistance 
      (HOMA-IR) and also to investigate independent role of sex hormones in the 
      occurrence of T2DM among PM. SETTINGS AND DESIGN: Cross-sectional case-control 
      study. SUBJECTS AND METHODS: The present study was conducted in Endocrinology 
      department Guwahati, Medical College, Assam, India. The participants included 
      cases - PM women with T2DM (n = 100) and controls - Healthy PM women (n = 86). 
      The medical history, clinical examination, and investigations including total 
      testosterone, serum estradiol, SHBG, free testosterone index, high sensitivity 
      C-reactive protein (hs-CRP), lipid profile, fasting insulin, fasting plasma 
      glucose (FPG), and postprandial plasma glucose (PPPG) were done and analyzed. 
      HOMA-IR was calculated. STATISTICAL ANALYSIS: Pearson correlation between sex 
      hormone level and SHBG with plasma glucose, HbA1c, fasting insulin, hs-CRP, and 
      HOMA-IR was seen. Multivariance logistic analysis was done to find the 
      independent association between sex hormones/SHBG and the occurrence of T2 DM. P 
      < 0.05 was considered statistically significant. RESULTS: Among the cases, a 
      significant positive correlation was found between total testosterone/free 
      testosterone index with waist circumference, FPG PPPG, HbA1c, fasting insulin, 
      and HOMA-IR, and a significant negative correlation was found between SHBG and 
      FPG, PPPG, HbA1c, fasting insulin, and HOMA-IR (P < 0.01). The logistic analysis 
      showed total testosterone levels and SHBG are independently associated with the 
      occurrence of T2 DM among PM (P < 0.01). CONCLUSION: SHBG and testosterone levels 
      in PM can be a risk marker for the development of T2DM.
CI  - Copyright: (c) 2021 Journal of Mid-life Health.
FAU - Saikia, Uma K
AU  - Saikia UK
AD  - Department of Endocrinology, Guahati Medical College, Guwahati, Assam, India.
FAU - Jabbar, P K
AU  - Jabbar PK
AD  - Department of Endocrinology, Medical College, Thiruvananthapuram, Kerala, India.
FAU - Das, Darvin V
AU  - Das DV
AD  - Department of Endocrinology, Medical College, Thiruvananthapuram, Kerala, India.
LA  - eng
PT  - Journal Article
DEP - 20210727
PL  - India
TA  - J Midlife Health
JT  - Journal of mid-life health
JID - 101552746
PMC - PMC8409708
OTO - NOTNLM
OT  - Insulin resistance
OT  - menopause
OT  - sex hormone-binding globulins
OT  - testosterone
OT  - type 2 diabetes mellitus
COIS- There are no conflicts of interest.
EDAT- 2021/09/17 06:00
MHDA- 2021/09/17 06:01
PMCR- 2021/04/01
CRDT- 2021/09/16 07:02
PHST- 2020/07/06 00:00 [received]
PHST- 2021/04/20 00:00 [revised]
PHST- 2021/05/23 00:00 [accepted]
PHST- 2021/09/16 07:02 [entrez]
PHST- 2021/09/17 06:00 [pubmed]
PHST- 2021/09/17 06:01 [medline]
PHST- 2021/04/01 00:00 [pmc-release]
AID - JMH-12-155 [pii]
AID - 10.4103/jmh.JMH_142_20 [doi]
PST - ppublish
SO  - J Midlife Health. 2021 Apr-Jun;12(2):155-160. doi: 10.4103/jmh.JMH_142_20. Epub 
      2021 Jul 27.