PMID- 34526770 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20240403 IS - 1176-6336 (Print) IS - 1178-203X (Electronic) IS - 1176-6336 (Linking) VI - 17 DP - 2021 TI - Safety and Efficacy of Tafenoquine for Plasmodium vivax Malaria Prophylaxis and Radical Cure: Overview and Perspectives. PG - 989-999 LID - 10.2147/TCRM.S269336 [doi] AB - This article is inter alia a brief, first-stop guide to possible adverse events (AEs) associated with tafenoquine (TQ) intake. Safety and efficacy findings for TQ in Plasmodium vivax malaria prophylaxis and radical cure are summarized and some of the latest TQ-related studies (published in 2020 and 2021) are highlighted. In addition, little-known biological and other matters concerning malaria parasites and 8-aminoquinoline (8-AQ) drug action are discussed and some correct terminology pertinent to malaria is explained. CI - (c) 2021 Markus. FAU - Markus, Miles B AU - Markus MB AUID- ORCID: 0000-0002-3843-8409 AD - School of Animal, Plant and Environmental Sciences, Faculty of Science, University of the Witwatersrand, Johannesburg, South Africa. AD - Wits Research Institute for Malaria, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. LA - eng PT - Journal Article DEP - 20210908 PL - New Zealand TA - Ther Clin Risk Manag JT - Therapeutics and clinical risk management JID - 101253281 PMC - PMC8435617 OTO - NOTNLM OT - G6PD OT - WR238605 OT - chloroquine OT - hypnozoite OT - primaquine OT - relapse COIS- The author declares that he has no conflicts of interest, financial or otherwise. EDAT- 2021/09/17 06:00 MHDA- 2021/09/17 06:01 PMCR- 2021/09/08 CRDT- 2021/09/16 07:03 PHST- 2021/04/26 00:00 [received] PHST- 2021/08/20 00:00 [accepted] PHST- 2021/09/16 07:03 [entrez] PHST- 2021/09/17 06:00 [pubmed] PHST- 2021/09/17 06:01 [medline] PHST- 2021/09/08 00:00 [pmc-release] AID - 269336 [pii] AID - 10.2147/TCRM.S269336 [doi] PST - epublish SO - Ther Clin Risk Manag. 2021 Sep 8;17:989-999. doi: 10.2147/TCRM.S269336. eCollection 2021.