PMID- 34527488
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210917
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 8
DP  - 2021 Aug
TI  - Sirolimus in a Renal Transplant Recipient Infected With COVID-19: A Blessing in 
      Disguise?
PG  - e17102
LID - 10.7759/cureus.17102 [doi]
LID - e17102
AB  - Immunocompromised status Is often associated with severe coronavirus infection 
      given the inability of the immune system to combat the deadly severe acute 
      respiratory syndrome coronavirus 2 (SARS-CoV-2). Patients with multiple 
      comorbidities such as diabetes mellitus, hypertension, and chronic kidney disease 
      along with patients on immunosuppressants or chemotherapy are at higher risk of 
      getting infected during the ongoing pandemic with more probability of adverse 
      outcomes. However, we report a rare case of a renal transplant recipient who was 
      on sirolimus and contracted coronavirus disease (COVID-19). His 
      immunosuppressants were continued and he was managed with antiviral, steroids and 
      low molecular weight heparin and the patient responded well to the treatment and 
      recovered completely after a span of one week. Use of sirolimus in a patient with 
      renal transplant recipient helped in preventing intensification of the severity 
      in COVID-19 attributing to its inhibiting effect on mammalian target of rapamycin 
      (mTOR) which he was using post his renal transplant, therefore, proving to be a 
      blessing in disguise.
CI  - Copyright (c) 2021, Talwar et al.
FAU - Talwar, Dhruv
AU  - Talwar D
AD  - Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute 
      of Medical Sciences (Deemed to be University), Wardha, IND.
FAU - Kumar, Sunil
AU  - Kumar S
AD  - Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute 
      of Medical Sciences (Deemed to be University), Wardha, IND.
FAU - Acharya, Sourya
AU  - Acharya S
AD  - Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute 
      of Medical Sciences (Deemed to be University), Wardha, IND.
FAU - Hulkoti, Vidyashree
AU  - Hulkoti V
AD  - Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute 
      of Medical Sciences (Deemed to be University), Wardha, IND.
FAU - Annadatha, Akhilesh
AU  - Annadatha A
AD  - Department of Medicine, Jawaharlal Nehru Medical College, Datta Meghe Institute 
      of Medical Sciences (Deemed to be University), Wardha, IND.
LA  - eng
PT  - Case Reports
DEP - 20210811
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8432414
OTO - NOTNLM
OT  - chronic kidney disease
OT  - covid19
OT  - immunocompromised
OT  - mtor inhibitors
OT  - renal transplant
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/09/17 06:00
MHDA- 2021/09/17 06:01
PMCR- 2021/08/11
CRDT- 2021/09/16 07:15
PHST- 2021/08/11 00:00 [accepted]
PHST- 2021/09/16 07:15 [entrez]
PHST- 2021/09/17 06:00 [pubmed]
PHST- 2021/09/17 06:01 [medline]
PHST- 2021/08/11 00:00 [pmc-release]
AID - 10.7759/cureus.17102 [doi]
PST - epublish
SO  - Cureus. 2021 Aug 11;13(8):e17102. doi: 10.7759/cureus.17102. eCollection 2021 
      Aug.