PMID- 34527758
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2328-8930 (Print)
IS  - 2328-8930 (Electronic)
VI  - 8
IP  - 6
DP  - 2021 Jun 8
TI  - Tissue-specific distribution of legacy and novel per- and polyfluoroalkyl 
      substances in juvenile seabirds.
PG  - 457-462
LID - 10.1021/acs.estlett.1c00222 [doi]
AB  - Of the thousands of per- and polyfluoroalkyl substances (PFAS) in the 
      environment, few have been investigated in detail. In this study, we analyzed 36 
      legacy and emerging PFAS in multiple seabird tissues collected from individuals 
      from Massachusetts Bay, Narragansett Bay and the Cape Fear River Estuary. PFOS 
      was the dominant compound across multiple tissues, while long-chain 
      perfluorinated carboxylic acids (PFCAs) dominated in brain (mean = 44% of total 
      concentrations). Emerging perfluoroalkyl ether acids (PFEAs)-Nafion byproduct-2 
      and PFO5DoDA - were detected in greater than 90% of tissues in birds obtained 
      from a nesting region downstream from a major fluorochemical production site. 
      Compound ratios, relative body burden calculations, and electrostatic surface 
      potential calculations were used to describe partitioning behavior of PFEAs in 
      different tissues. Novel PFEAs preferentially partition into blood compared to 
      liver, and were documented in brain for the first time. PFO5DoDA showed a reduced 
      preference for brain compared to PFCAs and Nafion BP2. These results suggest 
      future monitoring efforts and toxicological studies should focus on novel PFAS 
      and long-chain PFCAs in multiple tissues beyond liver and blood, while exploring 
      the unique binding mechanisms driving uptake of multi-ether PFEAs.
FAU - Robuck, Anna R
AU  - Robuck AR
AD  - University of Rhode Island Graduate School of Oceanography, Narragansett, RI 
      02882.
FAU - McCord, James P
AU  - McCord JP
AD  - US Environmental Protection Agency, Center for Environmental Measurement and 
      Modeling, Durham, NC 27709.
FAU - Strynar, Mark J
AU  - Strynar MJ
AD  - US Environmental Protection Agency, Center for Environmental Measurement and 
      Modeling, Durham, NC 27709.
FAU - Cantwell, Mark G
AU  - Cantwell MG
AD  - US Environmental Protection Agency, Center for Environmental Measurement and 
      Modeling, Atlantic Coastal Environmental Sciences Division, Narragansett, RI 
      02882.
FAU - Wiley, David N
AU  - Wiley DN
AD  - National Oceanic and Atmospheric Administration Stellwagen Bank National Marine 
      Sanctuary, Scituate, MA 02066.
FAU - Lohmann, Rainer
AU  - Lohmann R
AD  - University of Rhode Island Graduate School of Oceanography, Narragansett, RI 
      02882.
LA  - eng
GR  - P42 ES027706/ES/NIEHS NIH HHS/United States
PT  - Journal Article
DEP - 20210517
PL  - United States
TA  - Environ Sci Technol Lett
JT  - Environmental science & technology letters
JID - 101628367
PMC - PMC8437152
MID - NIHMS1721078
OTO - NOTNLM
OT  - PFAS
OT  - PFOS
OT  - bioaccumulation
OT  - partitioning
OT  - seabirds
EDAT- 2021/09/17 06:00
MHDA- 2021/09/17 06:01
PMCR- 2022/06/08
CRDT- 2021/09/16 07:18
PHST- 2021/09/16 07:18 [entrez]
PHST- 2021/09/17 06:00 [pubmed]
PHST- 2021/09/17 06:01 [medline]
PHST- 2022/06/08 00:00 [pmc-release]
AID - 10.1021/acs.estlett.1c00222 [doi]
PST - ppublish
SO  - Environ Sci Technol Lett. 2021 Jun 8;8(6):457-462. doi: 
      10.1021/acs.estlett.1c00222. Epub 2021 May 17.