PMID- 34528231
OWN - NLM
STAT- MEDLINE
DCOM- 20211118
LR  - 20220428
IS  - 1439-3999 (Electronic)
IS  - 0023-2165 (Linking)
VI  - 238
IP  - 11
DP  - 2021 Nov
TI  - Reliability of Corneal, Epithelial, and Stromal Thickness Mapping for a 9-mm Zone 
      Using Spectral-Domain Optical Coherence Tomography.
PG  - 1213-1219
LID - 10.1055/a-1535-1685 [doi]
AB  - PURPOSE: To evaluate the reliability of spectral-domain optical coherence 
      tomography (SD-OCT; RTVue XR; Optovue, Inc., Fremont, CA, USA) for thickness 
      mapping of the entire cornea (CT), corneal epithelium (ET). and corneal stroma 
      (ST) over a 9-mm zone in healthy eyes. We sought to develop reference values for 
      different age groups and elucidate potential sex- and age-dependent 
      characteristics of corneal sublayer pachymetry maps. METHODS: Three consecutive 
      SD-OCT scans were obtained in 166 healthy right eyes (mean age = 50 +/- 20 years). 
      The thickness maps contain 25 sectors over a 9-mm diameter zone. To test 
      measurement reliability, intraclass correlation coefficients (ICC), coefficients 
      of variation (CoV), and within-subject standard deviations (WSSD) were 
      calculated. RESULTS: CT, ET, and ST ICCs ranged from 0.961 to 0.998, 0.896 to 
      0.945, and 0.955 to 0.998, respectively. CoV values for CT, ET, and ST ranged 
      between 0.3 and 1.5%, 1.6 and 4.2%, and 0.4 and 1.7%, respectively. WSSD ranged 
      from 6 to 41, 4 to 8, and 7 to 46 microm, respectively. A negative correlation was 
      found between age and ET (p < 0.05) but not between age and ST or CT. No 
      gender-related differences in CT, ET, or ST were detected. CoV of CT, ET, and ST 
      measurements showed a positive correlation with age in 28, 64, and 28% of the 
      sectors, respectively. CONCLUSION: SD-OCT is a rapid and noninvasive technique 
      that provides excellent reliability for corneal sublayer thickness measurements 
      over a 9-mm zone. The reliability of the ET measurement seems to be negatively 
      affected by age. Peripheral CT and global ET thin with age.
CI  - Thieme. All rights reserved.
FAU - Krause, Daniel
AU  - Krause D
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Mohr, Niklas
AU  - Mohr N
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Shajari, Mehdi
AU  - Shajari M
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Mayer, Wolfgang J
AU  - Mayer WJ
AUID- ORCID: 0000-0001-8891-4875
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Priglinger, Siegfried
AU  - Priglinger S
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
FAU - Luft, Nikolaus
AU  - Luft N
AD  - Department of Ophthalmology, Ludwig-Maximilians-University, Munich, Germany.
LA  - eng
PT  - Journal Article
TT  - Reliabilitat der Pachymetriemessung von Kornea, Korneaepithel und Korneastroma 
      mittels Spectral-Domain optische Koharenztomografie uber eine 9 mm grosse Zone.
DEP - 20210915
PL  - Germany
TA  - Klin Monbl Augenheilkd
JT  - Klinische Monatsblatter fur Augenheilkunde
JID - 0014133
SB  - IM
MH  - Adult
MH  - Aged
MH  - Cornea
MH  - Corneal Pachymetry
MH  - *Epithelium, Corneal/diagnostic imaging
MH  - Humans
MH  - Middle Aged
MH  - Reproducibility of Results
MH  - *Tomography, Optical Coherence
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/09/17 06:00
MHDA- 2021/11/19 06:00
CRDT- 2021/09/16 07:30
PHST- 2021/09/17 06:00 [pubmed]
PHST- 2021/11/19 06:00 [medline]
PHST- 2021/09/16 07:30 [entrez]
AID - 10.1055/a-1535-1685 [doi]
PST - ppublish
SO  - Klin Monbl Augenheilkd. 2021 Nov;238(11):1213-1219. doi: 10.1055/a-1535-1685. 
      Epub 2021 Sep 15.