PMID- 34528732
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20220310
IS  - 1873-474X (Electronic)
IS  - 0736-5748 (Linking)
VI  - 81
IP  - 8
DP  - 2021 Dec
TI  - Maternal LiCl exposure disrupts thyroid-cerebral axis in neonatal albino rats.
PG  - 741-758
LID - 10.1002/jdn.10151 [doi]
AB  - This work aimed to elucidate whether maternal lithium chloride (LiCl) exposure 
      disturbs the thyroid-cerebral axis in neonatal albino rats. 50 mg of 
      LiCl/kg b.wt. is orally given for pregnant Wistar rats from gestational day (GD) 
      1 to lactation day (LD) 28. The maternal administration of LiCl induced 
      follicular dilatation and degeneration, hyperplasia, lumen obliteration and 
      colloid vacuolation in the maternal and neonatal thyroid gland at postnatal days 
      (PNDs) 14, 21 and 28. Neuronal degeneration (spongiform), gliosis, nuclear 
      pyknosis, perivascular oedema, and meningeal hyperaemia were observed in the 
      neonatal cerebral cortex of the maternal LiCl-treated group at examined PNDs. 
      This disturbance appears to depend on intensification in the neonatal cerebral 
      malondialdehyde (MDA), nitric oxide (NO), and hydrogen peroxide (H(2) O(2) ) 
      levels, and attenuation in the glutathione (GSH), total thiol (t-SH), catalase 
      (CAT), and superoxide dismutase (SOD) levels. In the neonatal cerebrum, the fold 
      change in the relative mRNA expression of deiodinases (DII and DIII) increased 
      significantly at PNDs 21 and 14, respectively, in the maternal LiCl-treated 
      group. These data suggest that maternal LiCl may perturb the thyroid-cerebrum 
      axis generating neonatal neurodevelopmental disorder.
CI  - (c) 2021 International Society for Developmental Neuroscience.
FAU - Mohammed, Dena A E
AU  - Mohammed DAE
AD  - Division of Anatomy and Embryology, Zoology Department, Faculty of Science, 
      Beni-Suef University, Beni-Suef, Egypt.
FAU - Ahmed, Rasha R
AU  - Ahmed RR
AD  - Division of Histology and Cytology, Zoology Department, Faculty of Science, 
      Beni-Suef University, Beni-Suef, Egypt.
FAU - R G, Ahmed
AU  - R G A
AUID- ORCID: 0000-0001-5644-8291
AD  - Division of Anatomy and Embryology, Zoology Department, Faculty of Science, 
      Beni-Suef University, Beni-Suef, Egypt.
LA  - eng
GR  - YRP38/Beni-Suef University/
PT  - Journal Article
DEP - 20211007
PL  - United States
TA  - Int J Dev Neurosci
JT  - International journal of developmental neuroscience : the official journal of the 
      International Society for Developmental Neuroscience
JID - 8401784
RN  - 4Y8F71G49Q (Malondialdehyde)
RN  - EC 1.11.1.6 (Catalase)
RN  - EC 1.15.1.1 (Superoxide Dismutase)
RN  - G4962QA067 (Lithium Chloride)
RN  - GAN16C9B8O (Glutathione)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Catalase/metabolism
MH  - Cerebral Cortex/*drug effects/metabolism
MH  - Glutathione/metabolism
MH  - Lithium Chloride/*pharmacology
MH  - Malondialdehyde/metabolism
MH  - Oxidative Stress/*drug effects
MH  - Rats
MH  - Rats, Wistar
MH  - Superoxide Dismutase/metabolism
MH  - Thyroid Gland/*drug effects/metabolism
OTO - NOTNLM
OT  - antioxidants
OT  - cerebrum
OT  - dams
OT  - deiodinases
OT  - lithium chloride
OT  - neonates
OT  - prooxidants
OT  - thyroid
EDAT- 2021/09/17 06:00
MHDA- 2022/03/11 06:00
CRDT- 2021/09/16 09:02
PHST- 2021/07/23 00:00 [revised]
PHST- 2021/06/07 00:00 [received]
PHST- 2021/09/08 00:00 [accepted]
PHST- 2021/09/17 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2021/09/16 09:02 [entrez]
AID - 10.1002/jdn.10151 [doi]
PST - ppublish
SO  - Int J Dev Neurosci. 2021 Dec;81(8):741-758. doi: 10.1002/jdn.10151. Epub 2021 Oct 
      7.