PMID- 34530259
OWN - NLM
STAT- MEDLINE
DCOM- 20211005
LR  - 20211005
IS  - 1090-2414 (Electronic)
IS  - 0147-6513 (Linking)
VI  - 225
DP  - 2021 Dec 1
TI  - Curcumin hinders PBDE-47-induced neutrophil extracellular traps release via 
      Nrf2-associated ROS inhibition.
PG  - 112779
LID - S0147-6513(21)00891-5 [pii]
LID - 10.1016/j.ecoenv.2021.112779 [doi]
AB  - Polybrominated diphenyl ethers (PBDE-47), a kind of lipophilic persistent organic 
      pollutants (POPs) brominated flame retardant, has been widely used in various 
      consumer products. However, the toxicity of PBDE-47 on human immune system has 
      not been well elucidated. Neutrophil extracellular traps (NETs) contribute to the 
      innate immune responses, and the release of NETs is recognized as the most 
      important part of the extracellular killing mechanism. The aim of this study was 
      to investigate the effect of PBDE-47 on NETs and its possible molecular 
      mechanism, as well as the intervention effect of curcumin (Cur). In this study, 
      the formation of PBDE-47-induced NETs was observed by fluorescence microscopy and 
      scanning electron microscopy, and was also quantitatively detected by DNA dye 
      SYTOX green. In addition, we used Cur and Nrf2 inhibitor ML385 to explore the 
      role of reactive oxygen species (ROS), extracellular signal regulated kinase 
      (ERK) and p38 signaling pathway in PBDE-47-induced reticular formation. We 
      demonstrated that PBDE-47 could significantly induce the formation of NETs, and 
      its molecular mechanism might be related to ROS burst. Cur reduced ROS and 
      inhibited PBDE-47-induced NETs formation by interfering with Nrf2. In conclusion, 
      this study revealed that Cur hindered PBDE-47-induced NETs via Nrf2-associated 
      ROS inhibition, which enriched the cytotoxicity mechanism of PBDE-47, and 
      provided a new clue for the development of Cur as an antagonist of 
      PBDE-47-related immune injury.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Ye, Shuzi
AU  - Ye S
AD  - Xiangya School of Public Health, Central South University, Changsha 410078, PR 
      China. Electronic address: shuziye@csu.edu.cn.
FAU - Li, Siwen
AU  - Li S
AD  - Xiangya School of Public Health, Central South University, Changsha 410078, PR 
      China. Electronic address: lisiwen0529@163.com.
FAU - Ma, Yu
AU  - Ma Y
AD  - Xiangya School of Public Health, Central South University, Changsha 410078, PR 
      China. Electronic address: 196901002@csu.edu.cn.
FAU - Hu, Die
AU  - Hu D
AD  - Xiangya School of Public Health, Central South University, Changsha 410078, PR 
      China.
FAU - Xiao, Fang
AU  - Xiao F
AD  - Xiangya School of Public Health, Central South University, Changsha 410078, PR 
      China. Electronic address: fangxiao@csu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20210913
PL  - Netherlands
TA  - Ecotoxicol Environ Saf
JT  - Ecotoxicology and environmental safety
JID - 7805381
RN  - 0 (Halogenated Diphenyl Ethers)
RN  - 0 (NF-E2-Related Factor 2)
RN  - 0 (Reactive Oxygen Species)
RN  - 0N97R5X10X (2,2',4,4'-tetrabromodiphenyl ether)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - *Curcumin/pharmacology
MH  - *Extracellular Traps
MH  - Halogenated Diphenyl Ethers/toxicity
MH  - Humans
MH  - NF-E2-Related Factor 2/genetics
MH  - Reactive Oxygen Species
OTO - NOTNLM
OT  - Curcumin (Cur)
OT  - ERK/p38 MAPK signaling pathway
OT  - Neutrophil extracellular traps (NETs)
OT  - Polybrominated diphenyl ethers (PBDE-47)
OT  - Reactive oxygen species (ROS)
EDAT- 2021/09/17 06:00
MHDA- 2021/10/06 06:00
CRDT- 2021/09/16 20:21
PHST- 2021/06/24 00:00 [received]
PHST- 2021/08/24 00:00 [revised]
PHST- 2021/09/11 00:00 [accepted]
PHST- 2021/09/17 06:00 [pubmed]
PHST- 2021/10/06 06:00 [medline]
PHST- 2021/09/16 20:21 [entrez]
AID - S0147-6513(21)00891-5 [pii]
AID - 10.1016/j.ecoenv.2021.112779 [doi]
PST - ppublish
SO  - Ecotoxicol Environ Saf. 2021 Dec 1;225:112779. doi: 10.1016/j.ecoenv.2021.112779. 
      Epub 2021 Sep 13.