PMID- 34532625
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231103
IS  - 2474-7629 (Electronic)
IS  - 2474-7629 (Linking)
VI  - 6
IP  - 2
DP  - 2021
TI  - Systematic Review: Cardiac Metastasis of Lingual Squamous Cell Carcinoma.
PG  - 27297
LID - 10.51894/001c.27297 [doi]
LID - 27297
AB  - INTRODUCTION: Lingual squamous cell carcinoma (LSCC) is an aggressive malignancy 
      that carries significant mortality risk and the potential for cardiac metastasis. 
      The authors performed a systematic review designed to characterize disease 
      progression of LSCC cardiac metastasis by evaluating patient demographics, 
      characteristics, management, and clinical outcomes. METHODS: Two authors 
      independently screened articles in Embase, PubMed, and Cochrane Database of 
      Systematic Reviews up until December 2019 for study eligibility. Demographic 
      data, patient symptomatology, imaging findings, management strategies, and 
      patient outcomes were obtained and analyzed. The Oxford Centre for Evidence Based 
      Medicine (OCEBM) Levels of Evidence categorization was implemented to determine 
      the quality of studies selected in this review. RESULTS: From this review, a 
      total of 28 studies met inclusion criteria and received an OCEBM Level 4 evidence 
      designation. Thirty-one patients were identified with cardiac metastasis from 
      LSCC. Shortness of breath (29.0%) and chest pain (29.0%) were the most common 
      presenting symptoms, and pericardial effusion (29.2%) and right ventricular 
      outflow tract obstruction (25.0%) were the predominant echocardiogram findings. 
      Cardiac metastases most often presented in the right ventricle (56.7%), followed 
      by the left ventricle (43.3%). Palliative intervention (68.2%) or chemotherapy 
      (40.9%) were typically implemented as treatments. All sample patients expired 
      within one year of metastatic cancer diagnosis in cases that reported mortality 
      outcomes. CONCLUSIONS: Patients presenting with shortness of breath, tachycardia, 
      and a history of squamous cell carcinoma of the tongue may indicate evaluation 
      for LSCC cardiac metastasis. Although LSCC cardiac metastases typically favor the 
      right and left ventricles, they are not exclusive to these sites. Palliative care 
      may be indicated as treatment due to high mortality and overall poor outcomes 
      from current interventions.
FAU - Kerndt, Connor C
AU  - Kerndt CC
AD  - Spectrum Health/Michigan State University College of Human Medicine, Grand 
      Rapids, Michigan, USA.
FAU - Nessel, Trevor A
AU  - Nessel TA
AD  - Michigan State University College of Osteopathic Medicine, East Lansing, 
      Michigan, USA.
FAU - Bills, John A
AU  - Bills JA
AD  - Michigan State University College of Osteopathic Medicine, East Lansing, 
      Michigan, USA.
FAU - Shareef, Zaid J
AU  - Shareef ZJ
AD  - Michigan State University College of Osteopathic Medicine, East Lansing, 
      Michigan, USA.
FAU - Balinski, Alexander M
AU  - Balinski AM
AD  - Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA.
FAU - Mistry, Devin T
AU  - Mistry DT
AD  - Metro Health Hospital-University of Michigan, Wyoming, Michigan, USA.
LA  - eng
PT  - Journal Article
DEP - 20210830
PL  - United States
TA  - Spartan Med Res J
JT  - Spartan medical research journal
JID - 101739886
PMC - PMC8405280
OTO - NOTNLM
OT  - cancer
OT  - cardiac metastasis
OT  - squamous cell carcinoma
OT  - tongue
COIS- None
EDAT- 2021/09/18 06:00
MHDA- 2021/09/18 06:01
PMCR- 2021/08/30
CRDT- 2021/09/17 07:21
PHST- 2021/03/27 00:00 [received]
PHST- 2021/08/05 00:00 [accepted]
PHST- 2021/09/17 07:21 [entrez]
PHST- 2021/09/18 06:00 [pubmed]
PHST- 2021/09/18 06:01 [medline]
PHST- 2021/08/30 00:00 [pmc-release]
AID - 27297 [pii]
AID - 10.51894/001c.27297 [doi]
PST - epublish
SO  - Spartan Med Res J. 2021 Aug 30;6(2):27297. doi: 10.51894/001c.27297. eCollection 
      2021.