PMID- 34533535
OWN - NLM
STAT- MEDLINE
DCOM- 20210921
LR  - 20220426
IS  - 1827-675X (Electronic)
IS  - 0392-100X (Print)
IS  - 0392-100X (Linking)
VI  - 41
IP  - 4
DP  - 2021 Aug
TI  - Organ preservation and oncological outcomes in early laryngeal cancer: a 
      propensity score-based study.
PG  - 317-326
LID - 10.14639/0392-100X-N0870 [doi]
AB  - BACKGROUND: The rates of laryngeal preservation according to therapeutic modality 
      in patients with initial laryngeal squamous cell carcinoma (LSCC) are still 
      controversial. This study evaluated the rates of laryngeal preservation in 
      patients who underwent treatment with surgery or radiotherapy. METHODS: This 
      retrospective cohort study evaluated 151 patients with stage I or II LSCC. 
      Ninety-six patients were matched using a propensity-score and outcomes were 
      compared within this group. RESULTS: Regarding overall, cancer-specific survival 
      and larynx preservation, no differences were observed according to the 
      therapeutic modalities, but patients who underwent radiotherapy had a higher rate 
      of local recurrence than those who underwent surgery. Patients classified as ASA 
      3 or 4 and treated with radiotherapy showed a tendency of higher risk of larynx 
      loss. CONCLUSIONS: Patients with stage I or II laryngeal tumours can be submitted 
      to surgery or radiotherapy with similar rates of laryngeal preservation.
CI  - Copyright (c) 2021 Societa Italiana di Otorinolaringoiatria e Chirurgia 
      Cervico-Facciale, Rome, Italy.
FAU - de Carvalho, Genival Barbosa
AU  - de Carvalho GB
AD  - Head and Neck Surgery and Otorhinolaryngology Department, A. C. Camargo Cancer 
      Center, Sao Paulo, Brazil.
FAU - Kohler, Hugo Fontan
AU  - Kohler HF
AD  - Head and Neck Surgery and Otorhinolaryngology Department, A. C. Camargo Cancer 
      Center, Sao Paulo, Brazil.
FAU - de Mello, Julia Bette Homem
AU  - de Mello JBH
AD  - Head and Neck Surgery and Otorhinolaryngology Department, A. C. Camargo Cancer 
      Center, Sao Paulo, Brazil.
AD  - Carcinogenesis Molecular Program, National Institute of Cancer - INCA, Rio de 
      Janeiro, RJ, Brazil.
FAU - Lira, Renan Bezerra
AU  - Lira RB
AD  - Head and Neck Surgery and Otorhinolaryngology Department, A. C. Camargo Cancer 
      Center, Sao Paulo, Brazil.
FAU - Pellizzon, Antonio Cassio de Assis
AU  - Pellizzon ACA
AD  - Radiation Oncology Department, A. C. Camargo Cancer Center, Sao Paulo, Brazil.
FAU - Vartanian, Jose Guilherme
AU  - Vartanian JG
AD  - Head and Neck Surgery and Otorhinolaryngology Department, A. C. Camargo Cancer 
      Center, Sao Paulo, Brazil.
FAU - Kowalski, Luiz Paulo
AU  - Kowalski LP
AD  - Head and Neck Surgery and Otorhinolaryngology Department, A. C. Camargo Cancer 
      Center, Sao Paulo, Brazil.
AD  - Head and Neck Surgery Department and LIM 28, University of Sao Paulo Medical 
      School, Sao Paulo, Brazil.
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Acta Otorhinolaryngol Ital
JT  - Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di 
      otorinolaringologia e chirurgia cervico-facciale
JID - 8213019
SB  - IM
MH  - *Carcinoma, Squamous Cell/pathology/surgery
MH  - *Head and Neck Neoplasms
MH  - Humans
MH  - *Laryngeal Neoplasms/pathology/surgery
MH  - Laryngectomy
MH  - Neoplasm Recurrence, Local
MH  - Neoplasm Staging
MH  - Organ Preservation
MH  - Propensity Score
MH  - Retrospective Studies
MH  - Treatment Outcome
PMC - PMC8448187
OTO - NOTNLM
OT  - laryngeal neoplasms
OT  - laryngeal radiotherapy
OT  - laryngeal surgery
OT  - organ preservation
COIS- Conflict of interest The Authors declare no conflict of interest.
EDAT- 2021/09/18 06:00
MHDA- 2021/09/22 06:00
PMCR- 2021/08/01
CRDT- 2021/09/17 12:16
PHST- 2020/05/19 00:00 [received]
PHST- 2020/10/13 00:00 [accepted]
PHST- 2021/09/17 12:16 [entrez]
PHST- 2021/09/18 06:00 [pubmed]
PHST- 2021/09/22 06:00 [medline]
PHST- 2021/08/01 00:00 [pmc-release]
AID - 10.14639/0392-100X-N0870 [doi]
PST - ppublish
SO  - Acta Otorhinolaryngol Ital. 2021 Aug;41(4):317-326. doi: 
      10.14639/0392-100X-N0870.