PMID- 34533636
OWN - NLM
STAT- MEDLINE
DCOM- 20220215
LR  - 20230205
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Print)
IS  - 0940-5429 (Linking)
VI  - 59
IP  - 2
DP  - 2022 Feb
TI  - Characteristic phenotype of Chinese patients with adult-onset diabetes who are 
      autoantibody positive by 3-Screen ICA ELISA.
PG  - 189-196
LID - 10.1007/s00592-021-01778-8 [doi]
AB  - AIMS: To assess the prevalence of diabetes-associated autoantibodies in Chinese 
      patients recently diagnosed with adult-onset diabetes and to evaluate the 
      potential role of the autoantibody markers for characterization of disease 
      phenotype in the patient population. METHODS: The study included 1273 
      recent-onset adult patients with phenotypic type 2 diabetes mellitus (T2DM). 
      Serum samples were tested using the 3-Screen ICA ELISA (3-Screen) designed for 
      combined measurement of GADAb and/or IA-2Ab and/or ZnT8Ab. 3-Screen positive 
      samples were then tested for individual diabetes-associated and other 
      organ-specific autoantibodies. Clinical characteristics of patients positive and 
      negative in 3-Screen were analysed. RESULTS: Forty-four (3.5%) of the T2DM 
      patients were positive in 3-Screen, and 38 (86%) of these were also positive for 
      at least one of GADAb, IA-2Ab and ZnT8Ab in assays for the individual 
      autoantibodies. 3-Screen positive patients had lower BMI, higher HbA1c, lower 
      fasting insulin levels and lower fasting C-peptide levels compared to 3-Screen 
      negative patients. Analysis using a homeostatic model assessment (HOMA2) 
      indicated that HOMA2-beta-cell function was significantly lower for the forty-four 
      3-Screen positive patients compared to 3-Screen negative patients. Twenty (45%) 
      3-Screen positive patients were also positive for at least one thyroid 
      autoantibody. CONCLUSIONS: The 3-Screen ELISA has been used successfully for the 
      first time in China to detect diabetes autoantibodies in patients with phenotypic 
      T2DM. 3-Screen positive patients presented with poorer beta cell function.
CI  - (c) 2021. The Author(s).
FAU - Wang, Zhida
AU  - Wang Z
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China.
FAU - Guo, Liang
AU  - Guo L
AD  - FIRS Laboratories, RSR Ltd Parc Ty Glas, Llanishen, Cardiff, CF14 5DU, UK.
FAU - Chen, Shu
AU  - Chen S
AD  - FIRS Laboratories, RSR Ltd Parc Ty Glas, Llanishen, Cardiff, CF14 5DU, UK.
AD  - RSR Tianjin Biotech Ltd, Haitai Green Area, Hi Huayuan Industrial Park, Tianjin, 
      300384, China.
FAU - Guan, Jun
AU  - Guan J
AD  - RSR Tianjin Biotech Ltd, Haitai Green Area, Hi Huayuan Industrial Park, Tianjin, 
      300384, China.
FAU - Powell, Michael
AU  - Powell M
AD  - FIRS Laboratories, RSR Ltd Parc Ty Glas, Llanishen, Cardiff, CF14 5DU, UK.
FAU - Furmaniak, Jadwiga
AU  - Furmaniak J
AD  - FIRS Laboratories, RSR Ltd Parc Ty Glas, Llanishen, Cardiff, CF14 5DU, UK.
FAU - Rees Smith, Bernard
AU  - Rees Smith B
AD  - FIRS Laboratories, RSR Ltd Parc Ty Glas, Llanishen, Cardiff, CF14 5DU, UK.
AD  - RSR Tianjin Biotech Ltd, Haitai Green Area, Hi Huayuan Industrial Park, Tianjin, 
      300384, China.
FAU - Chen, Liming
AU  - Chen L
AUID- ORCID: 0000-0002-5682-2340
AD  - NHC Key Laboratory of Hormones and Development, Tianjin Key Laboratory of 
      Metabolic Diseases, Tianjin Medical University Chu Hsien-I Memorial Hospital & 
      Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, China. 
      xfx22081@vip.163.com.
LA  - eng
PT  - Journal Article
DEP - 20210917
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
RN  - 0 (Autoantibodies)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
SB  - IM
MH  - Autoantibodies
MH  - *Diabetes Mellitus, Type 1
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Glutamate Decarboxylase
MH  - Humans
MH  - Phenotype
PMC - PMC8841311
OTO - NOTNLM
OT  - Diabetes autoantibodies
OT  - GADAb
OT  - IA-2Ab
OT  - T2DM
OT  - ZnT8Ab
OT  - beta-cell function
COIS- LG, SC, JG, MP, JF and BRS are employees of RSR Ltd and/or RSR Tianjin Biotech 
      Ltd who develop, manufacture and sell diagnostic kits, including kits for 
      measuring diabetes-associated autoantibodies.
EDAT- 2021/09/18 06:00
MHDA- 2022/02/16 06:00
PMCR- 2021/09/17
CRDT- 2021/09/17 12:20
PHST- 2021/04/14 00:00 [received]
PHST- 2021/07/27 00:00 [accepted]
PHST- 2021/09/18 06:00 [pubmed]
PHST- 2022/02/16 06:00 [medline]
PHST- 2021/09/17 12:20 [entrez]
PHST- 2021/09/17 00:00 [pmc-release]
AID - 10.1007/s00592-021-01778-8 [pii]
AID - 1778 [pii]
AID - 10.1007/s00592-021-01778-8 [doi]
PST - ppublish
SO  - Acta Diabetol. 2022 Feb;59(2):189-196. doi: 10.1007/s00592-021-01778-8. Epub 2021 
      Sep 17.