PMID- 34534393
OWN - NLM
STAT- MEDLINE
DCOM- 20211231
LR  - 20211231
IS  - 1742-1241 (Electronic)
IS  - 1368-5031 (Linking)
VI  - 75
IP  - 12
DP  - 2021 Dec
TI  - Dietary insulin index and load with risk of breast cancer in a case-control 
      study.
PG  - e14883
LID - 10.1111/ijcp.14883 [doi]
AB  - OBJECTIVE: Circulating insulin levels have been positively associated with risk 
      of breast cancer (BrCa); however, it remains unclear whether a diet inducing an 
      elevated insulin response influences Breast risk. METHODS: In this study, 250 
      newly diagnosed breast cancer patients and 250 hospitalised controls were 
      recruited using convenience sampling. The dietary insulin index (DII) was 
      calculated by dividing the dietary insulin load by the total energy intake. 
      RESULTS: Compared with those in the lowest tertiles of DII and dietary insulin 
      load (DIL), subjects in the highest tertile were more likely to be overweight, 
      have a family history of breast and other types of cancer and a history of benign 
      breast diseases. After controlling for multiple potential confounders, a 
      significantly increased BrCa odds was observed in the highest tertiles of DII and 
      DIL score compared with the lowest tertiles (odds ratio (OR): 1.46; 95% CI: 
      0.67-3.19, P = .006) and (OR: 1.87; 95% CI: 0.92-3.80, P = .038), respectively. 
      CONCLUSIONS: Our findings suggest that a diet that induces an elevated 
      postprandial insulin response, indicated by higher DII and DIL scores, may 
      increase the odds of BrCa, especially among women.
CI  - (c) 2021 John Wiley & Sons Ltd.
FAU - Akbari, Atieh
AU  - Akbari A
AD  - Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
FAU - Sohouli, Mohammad Hassan
AU  - Sohouli MH
AD  - Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, 
      Iran.
AD  - Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food 
      Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Deliu Lozovanu, Oana
AU  - Deliu Lozovanu O
AD  - Normandie Universite Caen, Normandie, France.
FAU - Lotfi, Mojtaba
AU  - Lotfi M
AD  - Department of Pediatric Endocrinology and Metabolism, School of Medicine, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
FAU - Nabavizadeh, Raheleh
AU  - Nabavizadeh R
AD  - Pediatric Gastroenterology, Hepatology and Nutrition Research Center, Research 
      Institute for Children's Health, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Saeidi, Reza
AU  - Saeidi R
AD  - Department of Pediatric Endocrinology and Metabolism, School of Medicine, Mashhad 
      University of Medical Sciences, Mashhad, Iran.
AD  - Faculty of Medicine, Mofid Children's Hospital, Neonatal Research Center, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
DEP - 20211005
PL  - India
TA  - Int J Clin Pract
JT  - International journal of clinical practice
JID - 9712381
RN  - 0 (Insulin)
SB  - IM
MH  - *Breast Neoplasms/epidemiology/etiology
MH  - Case-Control Studies
MH  - Diet/adverse effects
MH  - Female
MH  - Humans
MH  - Inflammation
MH  - *Insulin
MH  - Odds Ratio
MH  - Risk Factors
EDAT- 2021/09/18 06:00
MHDA- 2022/01/01 06:00
CRDT- 2021/09/17 17:31
PHST- 2021/09/10 00:00 [revised]
PHST- 2021/04/21 00:00 [received]
PHST- 2021/09/13 00:00 [accepted]
PHST- 2021/09/18 06:00 [pubmed]
PHST- 2022/01/01 06:00 [medline]
PHST- 2021/09/17 17:31 [entrez]
AID - 10.1111/ijcp.14883 [doi]
PST - ppublish
SO  - Int J Clin Pract. 2021 Dec;75(12):e14883. doi: 10.1111/ijcp.14883. Epub 2021 Oct 
      5.