PMID- 34534845
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20211101
IS  - 1878-0180 (Electronic)
IS  - 1878-0180 (Linking)
VI  - 124
DP  - 2021 Dec
TI  - Experimental and computational analysis of a pharmaceutical-grade shape memory 
      polymer applied to the development of gastroretentive drug delivery systems.
PG  - 104814
LID - S1751-6161(21)00455-0 [pii]
LID - 10.1016/j.jmbbm.2021.104814 [doi]
AB  - The present paper aims at developing an integrated experimental/computational 
      approach towards the design of shape memory devices fabricated by hot-processing 
      with potential for use as gastroretentive drug delivery systems (DDSs) and for 
      personalized therapy if 4D printing is involved. The approach was tested on a 
      plasticized poly(vinyl alcohol) (PVA) of pharmaceutical grade, with a glass 
      transition temperature close to that of the human body (i.e., 37  degrees C). A 
      comprehensive experimental analysis was conducted in order to fully characterize 
      the PVA thermo-mechanical response as well as to provide the necessary data to 
      calibrate and validate the numerical predictions, based on a thermo-viscoelastic 
      constitutive model, implemented within a finite element framework. Particularly, 
      a thorough thermal, mechanical, and shape memory characterization under different 
      testing conditions and on different sample geometries was first performed. Then, 
      a prototype consisting of an S-shaped device was fabricated, deformed in a 
      temporary compact configuration and tested. Simulation results were compared with 
      the results obtained from shape memory experiments carried out on the prototype. 
      The proposed approach provided useful results and recommendations for the design 
      of PVA-based shape memory DDSs.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Inverardi, N
AU  - Inverardi N
AD  - Department of Mechanical and Industrial Engineering, University of Brescia, Via 
      Branze 38, 25133, Brescia, Italy; Italian Interuniversity Consortium on Materials 
      Science and Technology (INSTM), Research Unit of Brescia, Via Branze 38, 25133, 
      Brescia, Italy.
FAU - Scalet, G
AU  - Scalet G
AD  - Department of Civil Engineering and Architecture, University of Pavia, Via 
      Ferrata 3, 27100, Pavia, Italy; Italian Interuniversity Consortium on Materials 
      Science and Technology (INSTM), Research Unit of Pavia, Via Ferrata 3, 27100, 
      Pavia, Italy.
FAU - Melocchi, A
AU  - Melocchi A
AD  - Section of Pharmaceutical Technology and Legislation "Maria Edvige Sangalli", 
      Department of Pharmaceutical Sciences, University of Milano, Via G. Colombo 71, 
      20133, Milano, Italy.
FAU - Uboldi, M
AU  - Uboldi M
AD  - Section of Pharmaceutical Technology and Legislation "Maria Edvige Sangalli", 
      Department of Pharmaceutical Sciences, University of Milano, Via G. Colombo 71, 
      20133, Milano, Italy.
FAU - Maroni, A
AU  - Maroni A
AD  - Section of Pharmaceutical Technology and Legislation "Maria Edvige Sangalli", 
      Department of Pharmaceutical Sciences, University of Milano, Via G. Colombo 71, 
      20133, Milano, Italy.
FAU - Zema, L
AU  - Zema L
AD  - Section of Pharmaceutical Technology and Legislation "Maria Edvige Sangalli", 
      Department of Pharmaceutical Sciences, University of Milano, Via G. Colombo 71, 
      20133, Milano, Italy.
FAU - Gazzaniga, A
AU  - Gazzaniga A
AD  - Section of Pharmaceutical Technology and Legislation "Maria Edvige Sangalli", 
      Department of Pharmaceutical Sciences, University of Milano, Via G. Colombo 71, 
      20133, Milano, Italy.
FAU - Auricchio, F
AU  - Auricchio F
AD  - Department of Civil Engineering and Architecture, University of Pavia, Via 
      Ferrata 3, 27100, Pavia, Italy; Italian Interuniversity Consortium on Materials 
      Science and Technology (INSTM), Research Unit of Pavia, Via Ferrata 3, 27100, 
      Pavia, Italy.
FAU - Briatico-Vangosa, F
AU  - Briatico-Vangosa F
AD  - Department of Chemistry, Materials and Chemical Engineering "Giulio Natta", 
      Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133, Milano, Italy.
FAU - Baldi, F
AU  - Baldi F
AD  - Department of Mechanical and Industrial Engineering, University of Brescia, Via 
      Branze 38, 25133, Brescia, Italy; Italian Interuniversity Consortium on Materials 
      Science and Technology (INSTM), Research Unit of Brescia, Via Branze 38, 25133, 
      Brescia, Italy.
FAU - Pandini, S
AU  - Pandini S
AD  - Department of Mechanical and Industrial Engineering, University of Brescia, Via 
      Branze 38, 25133, Brescia, Italy; Italian Interuniversity Consortium on Materials 
      Science and Technology (INSTM), Research Unit of Brescia, Via Branze 38, 25133, 
      Brescia, Italy. Electronic address: stefano.pandini@unibs.it.
LA  - eng
PT  - Journal Article
DEP - 20210908
PL  - Netherlands
TA  - J Mech Behav Biomed Mater
JT  - Journal of the mechanical behavior of biomedical materials
JID - 101322406
RN  - 0 (Pharmaceutical Preparations)
RN  - 0 (Smart Materials)
RN  - 9002-89-5 (Polyvinyl Alcohol)
SB  - IM
MH  - Drug Delivery Systems
MH  - Humans
MH  - *Pharmaceutical Preparations
MH  - Polyvinyl Alcohol
MH  - Printing, Three-Dimensional
MH  - *Smart Materials
OTO - NOTNLM
OT  - Constitutive modeling
OT  - Drug delivery systems
OT  - Expandable gastroretentive drug delivery systems
OT  - Shape memory polymers
OT  - poly(vinyl alcohol)
EDAT- 2021/09/18 06:00
MHDA- 2021/11/03 06:00
CRDT- 2021/09/17 20:22
PHST- 2020/12/24 00:00 [received]
PHST- 2021/08/10 00:00 [revised]
PHST- 2021/09/03 00:00 [accepted]
PHST- 2021/09/18 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/09/17 20:22 [entrez]
AID - S1751-6161(21)00455-0 [pii]
AID - 10.1016/j.jmbbm.2021.104814 [doi]
PST - ppublish
SO  - J Mech Behav Biomed Mater. 2021 Dec;124:104814. doi: 10.1016/j.jmbbm.2021.104814. 
      Epub 2021 Sep 8.