PMID- 34535106 OWN - NLM STAT- MEDLINE DCOM- 20211025 LR - 20211025 IS - 1471-2431 (Electronic) IS - 1471-2431 (Linking) VI - 21 IP - 1 DP - 2021 Sep 17 TI - Characteristics of childhood allergic diseases in outpatient and emergency departments in Shanghai, China, 2016-2018: a multicenter, retrospective study. PG - 409 LID - 10.1186/s12887-021-02880-0 [doi] LID - 409 AB - BACKGROUND: The prevalence of allergic diseases (ADs), such as asthma and allergic rhinitis (AR), is increasing worldwide in both adults and children. Although ADs are common and frequently coexist in outpatient care, city-level data regarding the characteristics of childhood AD remain limited in China. This study aimed to assess the profile and characteristics of ADs in the city of Shanghai. METHODS: A multicenter retrospective study was designed to collect routine administrative data from outpatient and emergency departments from 66 hospitals in Shanghai, China, from 2016 to 2018. Children with asthma, AR, allergic conjunctivitis (AC), and allergic skin diseases were investigated. Demographic characteristics, patients visit pattern, spectrum of diagnosis, and comorbidities were analyzed. RESULTS: A total of 2,376,150 outpatient and emergency visits for ADs were included in the period from 2016 to 2018. Allergic skin diseases accounted for 38.9%, followed by asthma (34.8%), AR (22.9%), and AC (3.3%), with a male predominance in all four diseases. Asthma and allergic skin diseases were most frequent in the 1 to < 4 years of age group, while AR and AC were more common in the 4 to < 7 years of age group. Asthma accounted for the greatest number of annual and emergency visits. The most frequent comorbidity of asthma was lower respiratory tract infection (LRTI) (49.3%), followed by AR (20.5%) and upper respiratory tract infection (14.1%). The most common comorbidities of AR were otitis media (23.4%), adenoid hypertrophy/obstructive sleep apnea (22.1%), followed by LRTI (12.1%), asthma (9.4%) and chronic pharyngitis (8.9%). CONCLUSIONS: Asthma and allergic skin diseases were the most common ADs in outpatient and emergency departments in the study period. Respiratory tract infection was the most common comorbidity of asthma in children. More attention should be devoted to the treatment of comorbidities to improve childhood AD outcomes with a better understanding of the characteristics of ADs in outpatient care. CI - (c) 2021. The Author(s). FAU - Qi, Yuanyuan AU - Qi Y AD - Department of Respiratory Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Shi, Peng AU - Shi P AD - Department of Data Management and Statistics, Children's Hospital of Fudan University, Shanghai, China. FAU - Chen, Renjie AU - Chen R AD - School of Public Health, Key Lab of Public Health Safety of the Ministry of Education and NHC Key Laboratory of Health Technology Assessment, Fudan University, Shanghai, 200032, China. FAU - Zhou, Yufeng AU - Zhou Y AD - Institute of Pediatrics, Children's Hospital of Fudan University, Shanghai, 201102, China. AD - Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China. FAU - Liu, Lijuan AU - Liu L AD - Department of Respiratory Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Hong, Jianguo AU - Hong J AD - Department of Pediatrics, Shanghai General Hospital, Shanghai Jiaotong University, Shanghai, 200080, China. FAU - Cao, Lanfang AU - Cao L AD - Department of Pediatrics, Renji Hospital, Shanghai Jiao Tong University, Shanghai, 200127, China. FAU - Lu, Yanming AU - Lu Y AD - Department of Pediatrics, South Campus, Renji Hospital, Shanghai Jiao Tong University, Shanghai, 201112, China. FAU - Dong, Xiaoyan AU - Dong X AD - Department of Respiratory Medicine, Children's Hospital of Shanghai Jiaotong University, Shanghai, 200040, China. FAU - Li, Jing AU - Li J AD - Big Data Product Department, Wonders Information Co. Ltd., Shanghai, China. FAU - Shi, Yu AU - Shi Y AD - Big Data Product Department, Wonders Information Co. Ltd., Shanghai, China. FAU - Xia, Min AU - Xia M AD - Department of Pediatrics, Renji Hospital, Shanghai Jiao Tong University, Shanghai, 200127, China. FAU - Ding, Bo AU - Ding B AD - Department of Pediatrics, South Campus, Renji Hospital, Shanghai Jiao Tong University, Shanghai, 201112, China. FAU - Qian, Liling AU - Qian L AD - Department of Respiratory Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Wang, Libo AU - Wang L AD - Department of Respiratory Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Zhou, Wenhao AU - Zhou W AD - Department of Neonatology, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Gui, Yonghao AU - Gui Y AD - Cardiovascular Center, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. FAU - Zhang, Xiaobo AU - Zhang X AD - Department of Respiratory Medicine, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, 201102, China. zhangxiaobo0307@163.com. LA - eng PT - Journal Article PT - Multicenter Study PT - Research Support, Non-U.S. Gov't DEP - 20210917 PL - England TA - BMC Pediatr JT - BMC pediatrics JID - 100967804 SB - IM MH - Adult MH - Child MH - China/epidemiology MH - Emergency Service, Hospital MH - Female MH - Humans MH - Male MH - *Outpatients MH - Retrospective Studies MH - *Rhinitis, Allergic/epidemiology PMC - PMC8447671 OTO - NOTNLM OT - Allergic diseases OT - Allergic rhinitis OT - Asthma OT - Comorbidity OT - Outpatient visit COIS- The authors declare that they have no competing interests. EDAT- 2021/09/19 06:00 MHDA- 2021/10/26 06:00 PMCR- 2021/09/17 CRDT- 2021/09/18 05:24 PHST- 2021/01/28 00:00 [received] PHST- 2021/08/31 00:00 [accepted] PHST- 2021/09/18 05:24 [entrez] PHST- 2021/09/19 06:00 [pubmed] PHST- 2021/10/26 06:00 [medline] PHST- 2021/09/17 00:00 [pmc-release] AID - 10.1186/s12887-021-02880-0 [pii] AID - 2880 [pii] AID - 10.1186/s12887-021-02880-0 [doi] PST - epublish SO - BMC Pediatr. 2021 Sep 17;21(1):409. doi: 10.1186/s12887-021-02880-0.