PMID- 34536012
OWN - NLM
STAT- MEDLINE
DCOM- 20220302
LR  - 20220919
IS  - 1745-1701 (Electronic)
IS  - 0586-7614 (Print)
IS  - 0586-7614 (Linking)
VI  - 48
IP  - 1
DP  - 2022 Jan 21
TI  - Sleep Disturbance in Individuals at Clinical High Risk for Psychosis.
PG  - 111-121
LID - 10.1093/schbul/sbab104 [doi]
AB  - INTRODUCTION: Disturbed sleep is a common feature of psychotic disorders that is 
      also present in the clinical high risk (CHR) state. Evidence suggests a potential 
      role of sleep disturbance in symptom progression, yet the interrelationship 
      between sleep and CHR symptoms remains to be determined. To address this 
      knowledge gap, we examined the association between disturbed sleep and CHR 
      symptoms over time. METHODS: Data were obtained from the North American Prodrome 
      Longitudinal Study (NAPLS)-3 consortium, including 688 CHR individuals and 94 
      controls (mean age 18.25, 46% female) for whom sleep was tracked prospectively 
      for 8 months. We used Cox regression analyses to investigate whether sleep 
      disturbances predicted conversion to psychosis up to >2 years later. With 
      regressions and cross-lagged panel models, we analyzed longitudinal and 
      bidirectional associations between sleep (the Pittsburgh Sleep Quality Index in 
      conjunction with additional sleep items) and CHR symptoms. We also investigated 
      the independent contribution of individual sleep characteristics on CHR symptom 
      domains separately and explored whether cognitive impairments, stress, 
      depression, and psychotropic medication affected the associations. RESULTS: 
      Disturbed sleep at baseline did not predict conversion to psychosis. However, 
      sleep disturbance was strongly correlated with heightened CHR symptoms over time. 
      Depression accounted for half of the association between sleep and symptoms. 
      Importantly, sleep was a significant predictor of CHR symptoms but not vice 
      versa, although bidirectional effect sizes were similar. DISCUSSION: The critical 
      role of sleep disturbance in CHR symptom changes suggests that sleep may be a 
      promising intervention target to moderate outcome in the CHR state.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of the 
      Maryland Psychiatric Research Center.All rights reserved. For permissions, please 
      email: journals.permissions@oup.com.
FAU - Zaks, Nina
AU  - Zaks N
AD  - Department of Psychiatry, Icahn School of Medicine, Mount Sinai, NY, USA.
FAU - Velikonja, Tjasa
AU  - Velikonja T
AD  - Department of Psychiatry, Icahn School of Medicine, Mount Sinai, NY, USA.
AD  - Evidence Based Practice Unit, Anna Freud National Centre for Children and 
      Families, London, UK.
FAU - Parvaz, Muhammad A
AU  - Parvaz MA
AD  - Department of Psychiatry, Icahn School of Medicine, Mount Sinai, NY, USA.
AD  - Department of Neuroscience, Icahn School of Medicine, Mount Sinai, NY, USA.
FAU - Zinberg, Jamie
AU  - Zinberg J
AD  - Department of Psychiatry and Biobehavioral Sciences, Semel Institute for 
      Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
FAU - Done, Monica
AU  - Done M
AD  - Department of Psychiatry and Biobehavioral Sciences, Semel Institute for 
      Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
FAU - Mathalon, Daniel H
AU  - Mathalon DH
AD  - San Francisco VA Health Care System.
AD  - University of California, San Francisco, CA, USA.
FAU - Addington, Jean
AU  - Addington J
AD  - Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada.
FAU - Cadenhead, Kristin
AU  - Cadenhead K
AUID- ORCID: 0000-0002-5952-4605
AD  - Department of Psychiatry, University of California San Diego (UCSD), La Jolla, 
      CA, USA.
FAU - Cannon, Tyrone
AU  - Cannon T
AD  - Departments of Psychiatry and Psychology, Yale University, New Haven, CT, USA.
FAU - Cornblatt, Barbara
AU  - Cornblatt B
AD  - Department of Psychology, Hofstra North Shore-LIJ School of Medicine, Hempstead, 
      NY, USA.
AD  - Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Manhasset, NY, 
      and Feinstein Institute for Medical Research, Garden City, NY, USA.
FAU - McGlashan, Thomas
AU  - McGlashan T
AD  - Departments of Psychiatry and Psychology, Yale University, New Haven, CT, USA.
FAU - Perkins, Diana
AU  - Perkins D
AD  - Department of Psychiatry, University of North Carolina, Chapel Hill, NC, USA.
FAU - Stone, William S
AU  - Stone WS
AUID- ORCID: 0000-0003-2932-7288
AD  - Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
FAU - Tsuang, Ming
AU  - Tsuang M
AD  - Department of Psychiatry, University of California San Diego (UCSD), La Jolla, 
      CA, USA.
FAU - Walker, Elaine
AU  - Walker E
AUID- ORCID: 0000-0002-9798-8101
AD  - Department of Psychology, Emory University, Atlanta, Georgia, USA.
FAU - Woods, Scott W
AU  - Woods SW
AD  - Departments of Psychiatry and Psychology, Yale University, New Haven, CT, USA.
FAU - Keshavan, Matcheri S
AU  - Keshavan MS
AD  - Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA, USA.
FAU - Buysse, Daniel J
AU  - Buysse DJ
AUID- ORCID: 0000-0002-3288-1864
AD  - University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
FAU - Velthorst, Eva
AU  - Velthorst E
AD  - Department of Psychiatry, Icahn School of Medicine, Mount Sinai, NY, USA.
AD  - Seaver Center of Research and Treatment, Icahn School of Medicine, Mount Sinai, 
      NY, USA.
FAU - Bearden, Carrie E
AU  - Bearden CE
AUID- ORCID: 0000-0002-8516-923X
AD  - Department of Psychiatry and Biobehavioral Sciences, Semel Institute for 
      Neuroscience and Human Behavior, University of California, Los Angeles, CA, USA.
AD  - Department of Psychology, University of California, Los Angeles, Los Angeles, CA, 
      USA.
LA  - eng
GR  - K01 DA043615/DA/NIDA NIH HHS/United States
GR  - P50 DA046346/DA/NIDA NIH HHS/United States
GR  - U01 MH081902/MH/NIMH NIH HHS/United States
GR  - R01 MH102377/MH/NIMH NIH HHS/United States
GR  - U01 MH081984/MH/NIMH NIH HHS/United States
GR  - U01 MH082022/MH/NIMH NIH HHS/United States
GR  - R01 MH108574/MH/NIMH NIH HHS/United States
GR  - U01 MH081988/MH/NIMH NIH HHS/United States
GR  - U01 MH081944/MH/NIMH NIH HHS/United States
GR  - R01 MH074794/MH/NIMH NIH HHS/United States
GR  - U01 MH076989/MH/NIMH NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - U01 MH082004/MH/NIMH NIH HHS/United States
GR  - U01 MH081928/MH/NIMH NIH HHS/United States
GR  - P41 EB015902/EB/NIBIB NIH HHS/United States
GR  - U01 MH081857/MH/NIMH NIH HHS/United States
GR  - UH3 HL125103/HL/NHLBI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Schizophr Bull
JT  - Schizophrenia bulletin
JID - 0236760
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - *Disease Progression
MH  - Female
MH  - Humans
MH  - Longitudinal Studies
MH  - Male
MH  - North America
MH  - *Prodromal Symptoms
MH  - Prognosis
MH  - *Psychotic Disorders/diagnosis/epidemiology/physiopathology
MH  - Risk
MH  - *Schizophrenia/diagnosis/epidemiology/physiopathology
MH  - *Sleep Wake Disorders/diagnosis/epidemiology/physiopathology
MH  - Young Adult
PMC - PMC8781348
OTO - NOTNLM
OT  - prodrome
OT  - psychotic disorders
OT  - schizophrenia
OT  - ultra-high risk
EDAT- 2021/09/19 06:00
MHDA- 2022/03/03 06:00
PMCR- 2022/09/18
CRDT- 2021/09/18 08:35
PHST- 2021/09/19 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/09/18 08:35 [entrez]
PHST- 2022/09/18 00:00 [pmc-release]
AID - 6372185 [pii]
AID - sbab104 [pii]
AID - 10.1093/schbul/sbab104 [doi]
PST - ppublish
SO  - Schizophr Bull. 2022 Jan 21;48(1):111-121. doi: 10.1093/schbul/sbab104.