PMID- 34536430
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220318
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 417
DP  - 2022 Jan 24
TI  - The resting-state cerebro-cerebellar function connectivity and associations with 
      verbal working memory performance.
PG  - 113586
LID - S0166-4328(21)00474-5 [pii]
LID - 10.1016/j.bbr.2021.113586 [doi]
AB  - The cerebellum plays an important role in cognitive functions through connecting 
      with the cerebral cortical areas. However, the relationship between the 
      resting-state functional connectivity (FC) pattern of human cerebro-cerebellar 
      circuits and cognition is not fully understood. The present study investigated 
      the FC patterns of human cerebro-cerebellar circuits and their associations with 
      verbal working memory performance (an n-back task with three subtasks: 0-back, 
      1-back, and 2-back) through resting-state functional magnetic resonance imaging 
      (fMRI) data from 34 healthy subjects. The whole-brain connectivity analysis was 
      used to identify the cortical hubs as regions of interest (ROI). Then ROI-based 
      FC analysis was performed to investigate the connectivity characteristics within 
      the key cortical hubs and their associations with n-back task performance. The 
      results showed that the bilateral cerebellum lobule VI as central hubs had 
      increased FC with the default mode network (DMN) node (e.g., right posterior 
      cingulate cortex) and salient network (SN) node (e.g., right anterior cingulate 
      cortex), while decreased FC with the executive control network (ECN) node (e.g., 
      the bilateral superior frontal gyrus). Furthermore, FC values of the cerebellum 
      lobule VI with DMN and ECN nodes correlated with verbal working memory 
      performance (response time of 2-back task). The results suggest that the 
      cerebro-cerebellar circuits involve the underlying neural basis of verbal working 
      memory processing during the resting state.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Li, Yanyan
AU  - Li Y
AD  - School of Education, Xinyang College, Xinyang, China.
FAU - Yang, Lihao
AU  - Yang L
AD  - School of Education, Xinyang College, Xinyang, China.
FAU - Li, Lihua
AU  - Li L
AD  - School of Education, Xinyang College, Xinyang, China.
FAU - Xie, Yuanjun
AU  - Xie Y
AD  - School of Education, Xinyang College, Xinyang, China; Department of Radiology, 
      Xijing Hospital, Fourth Military Medical University, Xi'an, China.
FAU - Fang, Peng
AU  - Fang P
AD  - Military Medical Psychology School , Fourth Military Medical University, Xi'an, 
      China. Electronic address: fangpeng@fmmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210915
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
SB  - IM
MH  - Adult
MH  - Brain/physiology
MH  - Cerebellum/*physiology
MH  - Cerebral Cortex/*physiology
MH  - Cognition/*physiology
MH  - Default Mode Network/physiology
MH  - Female
MH  - Healthy Volunteers
MH  - Humans
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Memory, Short-Term/*physiology
MH  - Reaction Time
MH  - Verbal Learning/physiology
MH  - Young Adult
OTO - NOTNLM
OT  - Cerebellum
OT  - Cerebrum
OT  - Functional connectivity
OT  - N-back
OT  - Resting-state
OT  - Working memory
EDAT- 2021/09/19 06:00
MHDA- 2022/03/19 06:00
CRDT- 2021/09/18 20:10
PHST- 2021/06/30 00:00 [received]
PHST- 2021/08/30 00:00 [revised]
PHST- 2021/09/13 00:00 [accepted]
PHST- 2021/09/19 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2021/09/18 20:10 [entrez]
AID - S0166-4328(21)00474-5 [pii]
AID - 10.1016/j.bbr.2021.113586 [doi]
PST - ppublish
SO  - Behav Brain Res. 2022 Jan 24;417:113586. doi: 10.1016/j.bbr.2021.113586. Epub 
      2021 Sep 15.