PMID- 34536495
OWN - NLM
STAT- MEDLINE
DCOM- 20211115
LR  - 20211115
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 285
DP  - 2021 Nov 15
TI  - Exposure of pregnant rats to stress and/or sertraline: Side effects on maternal 
      health and neurobehavioral development of male offspring.
PG  - 119960
LID - S0024-3205(21)00947-4 [pii]
LID - 10.1016/j.lfs.2021.119960 [doi]
AB  - AIMS: Sertraline (SE) is one of the most prescribed medications for treating 
      gestational depression, anxiety and stress. However, little is known about its 
      effects on nervous-system development in offspring. Therefore, this study 
      investigated the somatic, reflex and neurobehavioral development of rats exposed 
      to SE during pregnancy, associated or not with stress. MAIN METHODS: Pregnant 
      Wistar rats were assigned to the following groups (n = 10-8 rats/group): CO - 
      control animals administered filtered water by gavage; SE - animals administered 
      20 mg/kg SE by gavage; ST - animals subjected to restraining stress and 
      administered filtered water; ST/SE - animals subjected to restraining stress and 
      administered 20 mg/kg SE. The treatment was administered between gestational days 
      (GD) 13 to 20. Somatic and reflex developments were investigated in the male 
      offspring from postnatal day (PND) 1 to 21. The elevated plus maze was performed 
      on PND 25 and 80. The open field and light/dark box test were performed on PND 90 
      and 100, respectively. KEY FINDINGS: Body weight reduction and vaginal bleeding 
      were observed in pregnant rats exposed to SE. The male offspring of the SE group 
      showed delay in incisor eruption, fur development and negative geotaxis. In 
      addition, the SE group was less exploratory (anxious personality) compared to the 
      CO and ST groups. SIGNIFICANCE: The results obtained in the present study 
      demonstrate that sertraline not only impairs maternal health, but also, 
      associated or not with stress, can compromise the somatic, reflex and 
      neurobehavioral development of male rats.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Lozano, Ana Flavia Quiarato
AU  - Lozano AFQ
AD  - Graduate Program in General and Applied Biology, Sao Paulo State University 
      (UNESP), Institute of Biosciences, Botucatu, SP, Brazil; Laboratory of 
      Reproductive and Developmental Biology and Toxicology, Department of Structural 
      and Functional Biology, Institute of Biosciences, Sao Paulo State University 
      (UNESP), Botucatu, SP, Brazil. Electronic address: anaaquiarato@gmail.com.
FAU - Moura, Mayara Silva
AU  - Moura MS
AD  - Graduate Program in General and Applied Biology, Sao Paulo State University 
      (UNESP), Institute of Biosciences, Botucatu, SP, Brazil; Laboratory of 
      Reproductive and Developmental Biology and Toxicology, Department of Structural 
      and Functional Biology, Institute of Biosciences, Sao Paulo State University 
      (UNESP), Botucatu, SP, Brazil.
FAU - Tavares, Bruna Marques
AU  - Tavares BM
AD  - Laboratory of Reproductive and Developmental Biology and Toxicology, Department 
      of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State 
      University (UNESP), Botucatu, SP, Brazil.
FAU - Kempinas, Wilma De Grava
AU  - Kempinas WG
AD  - Laboratory of Reproductive and Developmental Biology and Toxicology, Department 
      of Structural and Functional Biology, Institute of Biosciences, Sao Paulo State 
      University (UNESP), Botucatu, SP, Brazil.
LA  - eng
PT  - Journal Article
DEP - 20210915
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Antidepressive Agents)
RN  - QUC7NX6WMB (Sertraline)
SB  - IM
MH  - Animal Fur/*drug effects
MH  - Animals
MH  - Animals, Newborn
MH  - Antidepressive Agents/administration & dosage/*adverse effects
MH  - Female
MH  - Incisor/growth & development
MH  - Male
MH  - Maternal Exposure/*adverse effects
MH  - Maze Learning/drug effects
MH  - Pregnancy
MH  - Prenatal Exposure Delayed Effects/*chemically induced
MH  - Rats
MH  - Rats, Wistar
MH  - Reflex/drug effects
MH  - Sertraline/administration & dosage/*adverse effects
MH  - Stress, Psychological/*drug therapy
MH  - Taxis Response/drug effects
MH  - Tooth Eruption/*drug effects
MH  - Uterine Hemorrhage/*chemically induced
MH  - Weight Loss
OTO - NOTNLM
OT  - Gestational depression
OT  - Gestational stress
OT  - Neurosomatic development
OT  - Rat
OT  - Sertraline
OT  - Vaginal bleeding
EDAT- 2021/09/19 06:00
MHDA- 2021/11/16 06:00
CRDT- 2021/09/18 20:11
PHST- 2021/03/30 00:00 [received]
PHST- 2021/09/01 00:00 [revised]
PHST- 2021/09/09 00:00 [accepted]
PHST- 2021/09/19 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/09/18 20:11 [entrez]
AID - S0024-3205(21)00947-4 [pii]
AID - 10.1016/j.lfs.2021.119960 [doi]
PST - ppublish
SO  - Life Sci. 2021 Nov 15;285:119960. doi: 10.1016/j.lfs.2021.119960. Epub 2021 Sep 
      15.