PMID- 34536530
OWN - NLM
STAT- MEDLINE
DCOM- 20220302
LR  - 20240411
IS  - 1522-9653 (Electronic)
IS  - 1063-4584 (Linking)
VI  - 29
IP  - 12
DP  - 2021 Dec
TI  - Tibiofemoral articular cartilage composition differs based on serum biochemical 
      profiles following anterior cruciate ligament reconstruction.
PG  - 1732-1740
LID - S1063-4584(21)00905-5 [pii]
LID - 10.1016/j.joca.2021.09.005 [doi]
AB  - OBJECTIVE: Biochemical joint changes contribute to posttraumatic osteoarthritis 
      (PTOA) development following anterior cruciate ligament reconstruction (ACLR). 
      The purpose of this longitudinal cohort study was to compare tibiofemoral 
      cartilage composition between ACLR patients with different serum biochemical 
      profiles. We hypothesized that profiles of increased inflammation (monocyte 
      chemoattractant protein-1 [MCP-1]), type-II collagen turnover (type-II collagen 
      breakdown [C2C]:synthesis [CPII]), matrix degradation (matrix metalloproteinase-3 
      [MMP-3] and cartilage oligomeric matrix protein [COMP]) preoperatively to 
      6-months post-ACLR would be associated with greater tibiofemoral cartilage T1rho 
      relaxation times 12-months post-ACLR. DESIGN: Serum was collected from 24 
      patients (46% female, 22.1 +/- 4.2 years old, 24.0 +/- 2.6 kg/m(2) body mass index 
      [BMI]) preoperatively (6.4 +/- 3.6 days post injury) and 6-months post-ACLR. T1rho 
      Magnetic Resonance Imaging (MRI) was collected for medial and lateral 
      tibiofemoral articular cartilage at 12-months post-ACLR. A k-means cluster 
      analysis was used to identify profiles based on biomarker changes over time and 
      T1rho relaxation times were compared between cluster groups controlling for sex, 
      age, BMI, concomitant injury (either meniscal or chondral pathology), and Marx 
      Score. RESULTS: One cluster exhibited increases in MCP-1 and COMP while the other 
      demonstrated decreases in MCP-1 and COMP preoperatively to 6-months post-ACLR. 
      The cluster group with increases in MCP-1 and COMP demonstrated greater lateral 
      tibial (adjusted mean difference = 3.88, 95% confidence intervals [1.97-5.78]) 
      and femoral (adjusted mean difference = 12.71, 95% confidence intervals 
      [0.41-23.81]) T1rho relaxation times. CONCLUSION: Profiles of increased serum 
      levels of inflammation and matrix degradation markers preoperatively to 6-months 
      post-ACLR are associated with MRI changes consistent with lesser lateral 
      tibiofemoral cartilage proteoglycan density 12-months post-ACLR.
CI  - Copyright (c) 2021 Osteoarthritis Research Society International. Published by 
      Elsevier Ltd. All rights reserved.
FAU - Lisee, C
AU  - Lisee C
AD  - Department of Exercise and Sports Science, University of North Carolina at Chapel 
      Hill, NC, USA. Electronic address: liseecar@email.unc.edu.
FAU - Spang, J T
AU  - Spang JT
AD  - Department of Orthopaedics, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC, USA.
FAU - Loeser, R
AU  - Loeser R
AD  - Thurston Arthritis Research Center, University of North Carolina at Chapel Hill, 
      NC, USA.
FAU - Longobardi, L
AU  - Longobardi L
AD  - Department of Orthopaedics, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC, USA.
FAU - Lalush, D
AU  - Lalush D
AD  - Joint Department of Biomedical Engineering, North Carolina State University and 
      University of North Carolina at Chapel Hill, Raleigh, NC, USA.
FAU - Nissman, D
AU  - Nissman D
AD  - Department of Radiology, University of North Carolina at Chapel Hill, Chapel Hill 
      NC, USA.
FAU - Schwartz, T
AU  - Schwartz T
AD  - Department of Biostatistics, Gillings School of Global Public Health, University 
      of North Carolina at Chapel Hill, Chapel Hill, NC, USA; Thurston Arthritis 
      Research Center, University of North Carolina at Chapel Hill, NC, USA.
FAU - Hu, D
AU  - Hu D
AD  - Department of Orthopaedics, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC, USA.
FAU - Pietrosimone, B
AU  - Pietrosimone B
AD  - Department of Exercise and Sports Science, University of North Carolina at Chapel 
      Hill, NC, USA.
LA  - eng
GR  - P30 AR072580/AR/NIAMS NIH HHS/United States
GR  - R03 AR066840/AR/NIAMS NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210916
PL  - England
TA  - Osteoarthritis Cartilage
JT  - Osteoarthritis and cartilage
JID - 9305697
RN  - 0 (Biomarkers)
RN  - 0 (Cartilage Oligomeric Matrix Protein)
RN  - 0 (Chemokine CCL2)
SB  - IM
MH  - *Anterior Cruciate Ligament Reconstruction
MH  - Biomarkers/blood
MH  - Cartilage Oligomeric Matrix Protein/*blood
MH  - Cartilage, Articular/*diagnostic imaging
MH  - Chemokine CCL2/*blood
MH  - Cohort Studies
MH  - Female
MH  - Humans
MH  - Knee Joint/*diagnostic imaging
MH  - Longitudinal Studies
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Young Adult
OTO - NOTNLM
OT  - Biomarkers
OT  - Magnetic resonance imaging
OT  - Posttraumatic osteoarthritis
OT  - T1rho
COIS- Conflict of Interest The authors declare that they have no competing interests.
EDAT- 2021/09/19 06:00
MHDA- 2022/03/03 06:00
CRDT- 2021/09/18 20:12
PHST- 2020/12/28 00:00 [received]
PHST- 2021/07/31 00:00 [revised]
PHST- 2021/09/08 00:00 [accepted]
PHST- 2021/09/19 06:00 [pubmed]
PHST- 2022/03/03 06:00 [medline]
PHST- 2021/09/18 20:12 [entrez]
AID - S1063-4584(21)00905-5 [pii]
AID - 10.1016/j.joca.2021.09.005 [doi]
PST - ppublish
SO  - Osteoarthritis Cartilage. 2021 Dec;29(12):1732-1740. doi: 
      10.1016/j.joca.2021.09.005. Epub 2021 Sep 16.