PMID- 34536626 OWN - NLM STAT- MEDLINE DCOM- 20220406 LR - 20220406 IS - 1778-7254 (Electronic) IS - 1297-319X (Linking) VI - 89 IP - 2 DP - 2022 Mar TI - Analysis of vascular involvement in 460 patients with Behcet's syndrome: Clinical characteristics and associated factors. PG - 105277 LID - S1297-319X(21)00150-0 [pii] LID - 10.1016/j.jbspin.2021.105277 [doi] AB - OBJECTIVES: To describe demographic and clinical characteristics of vascular involvement in patients with Behcet's syndrome (BS) and to evaluate associations with such involvement. METHODS: We retrospectively evaluated records of 2118 BS patients. In total, 460 patients diagnosed with superficial thrombophlebitis (ST) and/or major vascular events (venous and/or arterial involvements) were included in current analysis. Isolated ST with no accompanying deep venous thrombosis might be accepted as part of skin involvement; therefore, we defined two different outcomes for vascular involvement ("any vascular event" and "major vascular events") and performed univariable and multivariable logistic regression to assess factors associated with these outcome variables. RESULTS: Overall, 68 (14.8%) patients had isolated ST, and 392 (85.2%) had major vascular events. The mean age of vascular BS was 33.8 (SD: 10.5) years and median follow-up was 13.9 (Q1-Q3: 8.3-22.9) years. The primary sites of major vascular events were deep venous thrombosis (n=358, 77.8%), pulmonary arterial involvement (n=66, 14.3%), extrapulmonary arterial involvement (n=52, 11.3%), and intracardiac thrombosis (n=14, 3.0%), respectively. Male sex was significantly associated with a higher risk for both outcome variables. When it was added to analysis, ST itself was the strongest explanatory variable that was associated with major vascular events in all multivariable models (ORs=11.9, 12.0, 13.0, and 18.9). While HLA-B51 was significantly associated with any vascular event, there was no similar observation for major vascular events. CONCLUSION: Male sex is a well-known risk factor for major vascular events in BS, but our study established that presence of ST was the strongest risk factor. CI - Copyright (c) 2021 Societe francaise de rhumatologie. Published by Elsevier Masson SAS. All rights reserved. FAU - Torgutalp, Murat AU - Torgutalp M AD - Department of Gastroenterology, Infectiology and Rheumatology (including Nutrition Medicine), Charite - Universitatsmedizin Berlin, Berlin, Germany; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey. Electronic address: murat.torgutalp@charite.de. FAU - Sahin Eroglu, Didem AU - Sahin Eroglu D AD - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey. FAU - Sezer, Serdar AU - Sezer S AD - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey; Clinic of Rheumatology, Ankara Training and Research Hospital, Ankara, Turkey. FAU - Yayla, Mucteba E AU - Yayla ME AD - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey; Clinic of Rheumatology, Ankara Training and Research Hospital, Ankara, Turkey. FAU - Karatas, Gokturk AU - Karatas G AD - Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey. FAU - Uslu Yurteri, Emine AU - Uslu Yurteri E AD - Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey; Clinic of Rheumatology, Hatay Training and Research Hospital, Hatay, Turkey. FAU - Turgay, Tahsin M AU - Turgay TM AD - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey. FAU - Kinikli, Gulay AU - Kinikli G AD - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey. FAU - Ates, Askin AU - Ates A AD - Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Ankara University, Ankara, Turkey. LA - eng PT - Journal Article DEP - 20210915 PL - France TA - Joint Bone Spine JT - Joint bone spine JID - 100938016 SB - IM MH - Adult MH - *Behcet Syndrome/complications/diagnosis/epidemiology MH - Humans MH - Logistic Models MH - Male MH - Pulmonary Artery MH - Retrospective Studies MH - Risk Factors OTO - NOTNLM OT - Arterial involvement OT - Behcet's syndrome OT - Superficial thrombophlebitis OT - Vascular Behcet OT - Venous thrombosis EDAT- 2021/09/19 06:00 MHDA- 2022/04/07 06:00 CRDT- 2021/09/18 20:14 PHST- 2021/06/14 00:00 [received] PHST- 2021/09/08 00:00 [accepted] PHST- 2021/09/19 06:00 [pubmed] PHST- 2022/04/07 06:00 [medline] PHST- 2021/09/18 20:14 [entrez] AID - S1297-319X(21)00150-0 [pii] AID - 10.1016/j.jbspin.2021.105277 [doi] PST - ppublish SO - Joint Bone Spine. 2022 Mar;89(2):105277. doi: 10.1016/j.jbspin.2021.105277. Epub 2021 Sep 15.