PMID- 34536750
OWN - NLM
STAT- MEDLINE
DCOM- 20220325
LR  - 20220325
IS  - 1573-2509 (Electronic)
IS  - 0920-9964 (Linking)
VI  - 237
DP  - 2021 Nov
TI  - Systemic lupus erythematosus and autoimmune features in chronic hospitalized 
      patients with schizophrenia.
PG  - 166-173
LID - S0920-9964(21)00357-1 [pii]
LID - 10.1016/j.schres.2021.08.032 [doi]
AB  - OBJECTIVES: Recent studies highlighted the link of schizophrenia risk with 
      genetic variations in complement, which share the same pathogenesis with systemic 
      lupus erythematosus (SLE). However, the coexistence of SLE and schizophrenia were 
      rarely reported. We aimed to explore the autoantibody profiles, complement levels 
      and prevalence of SLE in chronic schizophrenia patients. METHODS: A prospective, 
      cross-sectional study was conducted to recruit 481 long-term hospitalized 
      schizophrenia spectrum disorder patients in Yuli hospital, Taiwan. Severity of 
      schizophrenia was assessed by Positive and Negative Syndrome Scale (PANSS). 
      Immunologic tests of autoantibodies and complement levels were measured. 
      Genome-wide association analysis was conducted to compare genetic variants 
      between schizophrenia with SLE and non-SLE schizophrenia. RESULTS: In total, 47 
      (9.8%) and 31 (6.4%) participants had positive anti-nuclear antibody (ANA) and 
      anti-double stranded DNA (anti-dsDNA) antibodies, respectively. After 
      rheumatologic exams, 30 (6.2%) patients were diagnosed schizophrenia with SLE, 
      while 32 (6.7%) subjects were classified as schizophrenia with autoimmune 
      features. Schizophrenia patients with SLE had more arthritis, serositis, 
      homogenous ANA pattern, conceptual disorganization in PANSS and increased 
      salivation due to psychotropics compared with their counterparts. ANA titers and 
      complement levels were significantly correlated with PANSS scores and side effect 
      of psychotropics. No significant genetic variation between schizophrenia with SLE 
      and non-SLE schizophrenia were identified. CONCLUSION: SLE may coexist in chronic 
      hospitalized schizophrenia. Complement levels could be a potential biomarker in 
      schizophrenia patients. Considering the possible reversibility of psychotic 
      features and adverse effects of antipsychotics, SLE with psychosis should be 
      identified in patients with chronic hospitalized schizophrenia.
CI  - Copyright (c) 2021. Published by Elsevier B.V.
FAU - Chen, Yi-Ming
AU  - Chen YM
AD  - Division of Allergy, Immunology and Rheumatology, Taichung Veterans General 
      Hospital, Taichung, Taiwan; Department of Medical Research, Taichung Veterans 
      General Hospital, Taichung, Taiwan; School of Medicine, College of Medicine, 
      National Yang Ming Chiao Tung University, Taipei, Taiwan; Rong Hsing Research 
      Center for Translational Medicine, National Chung Hsing University, Taiwan; Ph.D. 
      Program in Translational Medicine, National Chung Hsing University, Taiwan.
FAU - Chen, Hsing-Kang
AU  - Chen HK
AD  - Department of Psychiatry, Yuli Hospital, Ministry of Health and Welfare, Hualien, 
      Taiwan.
FAU - Wu, Bo-Jian
AU  - Wu BJ
AD  - Department of Psychiatry, Yuli Hospital, Ministry of Health and Welfare, Hualien, 
      Taiwan.
FAU - Chen, I-Chieh
AU  - Chen IC
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung, 
      Taiwan.
FAU - Chen, Jun-Peng
AU  - Chen JP
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung, 
      Taiwan.
FAU - Lin, Ching-Heng
AU  - Lin CH
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung, 
      Taiwan; Department of Health Care Management, National Taipei University of 
      Nursing and Health Sciences, Taipei, Taiwan; Department of Industrial Engineering 
      and Enterprise Information, Tunghai University, Taichung, Taiwan; Department of 
      Public Health, College of Medicine, Fu Jen Catholic University, New Taipei City, 
      Taiwan; Institute of Public Health and Community Medicine Research Center, 
      National Yang Ming Chiao Tung University, Taipei, Taiwan. Electronic address: 
      epid@vghtc.gov.tw.
FAU - Hsiao, Tzu-Hung
AU  - Hsiao TH
AD  - Department of Medical Research, Taichung Veterans General Hospital, Taichung, 
      Taiwan; Department of Public Health, College of Medicine, Fu Jen Catholic 
      University, New Taipei City, Taiwan; Institute of Genomics and Bioinformatics, 
      National Chung Hsing University, Taichung, Taiwan. Electronic address: 
      thsiao@vghtc.gov.tw.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210915
PL  - Netherlands
TA  - Schizophr Res
JT  - Schizophrenia research
JID - 8804207
RN  - 0 (Autoantibodies)
SB  - IM
MH  - Autoantibodies
MH  - Cross-Sectional Studies
MH  - Genome-Wide Association Study
MH  - Humans
MH  - *Lupus Erythematosus, Systemic/epidemiology/genetics
MH  - Prospective Studies
MH  - *Schizophrenia/complications/epidemiology/genetics
OTO - NOTNLM
OT  - Autoantibody
OT  - Genome-wide association study
OT  - Positive and Negative Syndrome Scale
OT  - Schizophrenia
OT  - Systemic lupus erythematosus
EDAT- 2021/09/19 06:00
MHDA- 2022/03/26 06:00
CRDT- 2021/09/18 20:20
PHST- 2020/09/09 00:00 [received]
PHST- 2021/07/26 00:00 [revised]
PHST- 2021/08/24 00:00 [accepted]
PHST- 2021/09/19 06:00 [pubmed]
PHST- 2022/03/26 06:00 [medline]
PHST- 2021/09/18 20:20 [entrez]
AID - S0920-9964(21)00357-1 [pii]
AID - 10.1016/j.schres.2021.08.032 [doi]
PST - ppublish
SO  - Schizophr Res. 2021 Nov;237:166-173. doi: 10.1016/j.schres.2021.08.032. Epub 2021 
      Sep 15.