PMID- 34537344
OWN - NLM
STAT- MEDLINE
DCOM- 20211216
LR  - 20211216
IS  - 1873-6963 (Electronic)
IS  - 0965-2299 (Linking)
VI  - 63
DP  - 2021 Dec
TI  - The efficacy of high- and low-dose curcumin in knee osteoarthritis: A systematic 
      review and meta-analysis.
PG  - 102775
LID - S0965-2299(21)00116-3 [pii]
LID - 10.1016/j.ctim.2021.102775 [doi]
AB  - OBJECTIVES: The aim of this study was to critically appraise and evaluate effects 
      of low- and high-dose curcuminoids on pain and functional improvement in patients 
      with knee osteoarthritis (OA) and to compare adverse events (AEs) between 
      curcuminoids and non-steroid anti-inflammatory drugs (NSAIDs). METHODS: We 
      systematically reviewed all randomized controlled trials (RCTs) on curcuminoids 
      in knee osteoarthritis from the PubMed, Embase, Cochrane Library, AMED, Cinahl, 
      ISI Web of Science, Chinese medical database, and Indian Scienti fi c databases from 
      inception to June 21, 2021. RESULTS: We included eleven studies with a total of 
      1258 participants with primary knee OA. The meta-analysis results showed that 
      curcuminoids were significantly more effective than comparators regarding visual 
      analogue scale (VAS) and Western Ontario and McMaster Universities Arthritis 
      Index (WOMAC) pain scores. However, no significant difference in pain relief or 
      AEs between the high-dose (daily dose >/=1000 mg or total dose >/=42 gm) and low-dose 
      (daily dose <1000 mg or total dose <42 gm) curcuminoid treatments was observed. 
      When comparing curcumininoids versus NSAIDs, a significant difference in VAS pain 
      was found. For AE analysis, three of our included studies used NSAIDs as 
      comparators, with all reporting higher AE rates in the NSAID group, though 
      significance was reached in only one study. CONCLUSIONS: The results of our 
      meta-analysis suggest that low- and high-dose curcuminoids have similar pain 
      relief effects and AEs in knee OA. Curcuminoids are also associated with better 
      pain relief than NSAIDs; therefore, using curcuminoids as an adjunctive treatment 
      in knee OA is recommended.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.
FAU - Hsiao, An-Fang
AU  - Hsiao AF
AD  - Department of Physical Medicine and Rehabilitation, Cheng Ching Hospital Chung 
      Kang Branch, Taichung City, Taiwan, ROC.
FAU - Lien, Yi-Chieh
AU  - Lien YC
AD  - Department of Physical Medicine and Rehabilitation, Cardinal Tien Hospital An 
      Kang Branch, New Taipei City, Taiwan, ROC.
FAU - Tzeng, I-Shiang
AU  - Tzeng IS
AD  - Department of Research, Taipei Tzu chi Hospital, Buddhist Tzu chi Medical 
      Foundation, New Taipei City, Taiwan, ROC.
FAU - Liu, Chien-Ting
AU  - Liu CT
AD  - Department of Physical Medicine and Rehabilitation, Taipei Tzu chi Hospital, 
      Buddhist Tzu chi Medical Foundation, New Taipei City, Taiwan, ROC; Department of 
      Medicine, Tzu Chi University, Hualien, Taiwan, ROC.
FAU - Chou, Sheng-Hsun
AU  - Chou SH
AD  - Department of Physical Medicine and Rehabilitation, Taipei Tzu chi Hospital, 
      Buddhist Tzu chi Medical Foundation, New Taipei City, Taiwan, ROC.
FAU - Horng, Yi-Shiung
AU  - Horng YS
AD  - Department of Physical Medicine and Rehabilitation, Taipei Tzu chi Hospital, 
      Buddhist Tzu chi Medical Foundation, New Taipei City, Taiwan, ROC; Department of 
      Medicine, Tzu Chi University, Hualien, Taiwan, ROC. Electronic address: 
      yshorng2015@gmail.com.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Review
PT  - Systematic Review
DEP - 20210916
PL  - Scotland
TA  - Complement Ther Med
JT  - Complementary therapies in medicine
JID - 9308777
RN  - 0 (Anti-Inflammatory Agents, Non-Steroidal)
RN  - IT942ZTH98 (Curcumin)
SB  - IM
MH  - Anti-Inflammatory Agents, Non-Steroidal/therapeutic use
MH  - *Curcumin/therapeutic use
MH  - Humans
MH  - Knee Joint
MH  - *Osteoarthritis, Knee/drug therapy
MH  - Pain Measurement
MH  - Treatment Outcome
OTO - NOTNLM
OT  - Clinical trial
OT  - Curcumin
OT  - Curcuminoid
OT  - Knee osteoarthritis
OT  - Meta-analysis
OT  - Systematic review
EDAT- 2021/09/20 06:00
MHDA- 2021/12/17 06:00
CRDT- 2021/09/19 20:29
PHST- 2021/05/05 00:00 [received]
PHST- 2021/08/11 00:00 [revised]
PHST- 2021/09/14 00:00 [accepted]
PHST- 2021/09/20 06:00 [pubmed]
PHST- 2021/12/17 06:00 [medline]
PHST- 2021/09/19 20:29 [entrez]
AID - S0965-2299(21)00116-3 [pii]
AID - 10.1016/j.ctim.2021.102775 [doi]
PST - ppublish
SO  - Complement Ther Med. 2021 Dec;63:102775. doi: 10.1016/j.ctim.2021.102775. Epub 
      2021 Sep 16.