PMID- 34537923
OWN - NLM
STAT- MEDLINE
DCOM- 20220224
LR  - 20240226
IS  - 1559-0259 (Electronic)
IS  - 1530-7905 (Linking)
VI  - 21
IP  - 12
DP  - 2021 Dec
TI  - Astaxanthin Ameliorates Blood Pressure in Salt-Induced Prehypertensive Rats 
      Through ROS/MAPK/NF-kappaB Pathways in the Hypothalamic Paraventricular Nucleus.
PG  - 1045-1057
LID - 10.1007/s12012-021-09695-6 [doi]
AB  - Astaxanthin (AST) has a variety of biochemical effects, including 
      anti-inflammatory, antioxidative, and antihypertensive functions. The aim of the 
      present study was to determine whether AST ameliorates blood pressure in 
      salt-induced prehypertensive rats by ROS/MAPK/NF-kappaB pathways in hypothalamic 
      paraventricular nucleus.To explore the central effects of AST on the development 
      of blood pressure, prehypertensive rats were induced by a high-salt diet (HS, 8% 
      NaCl) and its control groups were treated with normal-salt diet (NS, 0.3% NaCl). 
      The Dahl salt-sensitive (S) rats with HS diet for 6 weeks received AST or vehicle 
      by gastric perfusion for 6 weeks. Compared to those with NS diet, rats with HS 
      diet exhibited increased mean arterial pressure (MAP) and heart rate (HR). These 
      increases were associated with higher plasma level of norepinephrine (NE), 
      interleukin 1beta (IL-1beta), and interleukin 6 (IL-6); elevated PVN level of reactive 
      oxygen species (ROS), NOX2, and NOX4, that of IL-1beta, IL-6, monocyte chemotactic 
      protein 1 (MCP-1), tyrosine hydroxylase (TH), phosphorylation 
      extracellular-signal-regulated kinase (p-ERK1/2), phosphorylation Jun N-terminal 
      kinases (p-JNK), nuclear factor-kappa B (NF-kappaB) activity; and lower levels of 
      IL-10, superoxide dismutase (SOD), and catalase (CAT) in the PVN. In addition, 
      our data demonstrated that chronic AST treatment ameliorated these changes in the 
      HS but not NS diet rats. These data suggested that AST could alleviate 
      prehypertensive response in HS-induced prehypertension through ROS/MAPK/NF-kappaB 
      pathways in the PVN.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Science+Business 
      Media, LLC, part of Springer Nature.
FAU - Gao, Hong-Li
AU  - Gao HL
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Yu, Xiao-Jing
AU  - Yu XJ
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Zhang, Yan
AU  - Zhang Y
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Wang, Chen-Long
AU  - Wang CL
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Lei, Yi-Ming
AU  - Lei YM
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Yu, Jia-Yue
AU  - Yu JY
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Zong, Dong-Miao
AU  - Zong DM
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Liu, Kai-Li
AU  - Liu KL
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Zhang, Dong-Dong
AU  - Zhang DD
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Li, Ying
AU  - Li Y
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Tian, Hua
AU  - Tian H
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China.
FAU - Zhang, Nian-Ping
AU  - Zhang NP
AD  - Department of Clinical Medicine, Medical School of Shanxi Datong University, 
      Datong, China. 603830770@qq.com.
FAU - Kang, Yu-Ming
AU  - Kang YM
AD  - Department of Physiology and Pathophysiology, Key Laboratory of Environment and 
      Genes Related to Diseases of Education Ministry of China, Xi'an Jiaotong 
      University School of Basic Medical Sciences, Xi'an Jiaotong University Health 
      Science Center, Shaanxi Engineering and Research Center of Vaccine, Xi'an, 
      710061, China. ykang@mail.xjtu.edu.cn.
LA  - eng
GR  - 81770426/national natural science foundation of china/
GR  - 82070439/national natural science foundation of china/
GR  - 82070440/national natural science foundation of china/
GR  - PY3A044/the fundamental research funds for the central universities/
GR  - xjh012019059/the fundamental research funds for the central universities/
GR  - 2019M663750/china postdoctoral science foundation/
GR  - 2020M683440/china postdoctoral science foundation/
GR  - 2021JQ-068/natural science basic research program of shaanxi/
GR  - 2020JM-079/natural science basic research program of shaanxi/
GR  - 2019JQ-605/natural science basic research program of shaanxi/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210918
PL  - United States
TA  - Cardiovasc Toxicol
JT  - Cardiovascular toxicology
JID - 101135818
RN  - 0 (Anti-Inflammatory Agents)
RN  - 0 (Antihypertensive Agents)
RN  - 0 (Antioxidants)
RN  - 0 (NF-kappa B)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Sodium Chloride, Dietary)
RN  - 0 (Xanthophylls)
RN  - 8XPW32PR7I (astaxanthine)
RN  - EC 2.7.11.24 (Mitogen-Activated Protein Kinases)
SB  - IM
MH  - Animals
MH  - Anti-Inflammatory Agents/pharmacology
MH  - Antihypertensive Agents/*pharmacology
MH  - Antioxidants/pharmacology
MH  - Arterial Pressure/*radiation effects
MH  - Disease Models, Animal
MH  - Male
MH  - Mitogen-Activated Protein Kinases/*metabolism
MH  - NF-kappa B/*metabolism
MH  - Oxidative Stress/*drug effects
MH  - Paraventricular Hypothalamic Nucleus/*drug effects/enzymology/physiopathology
MH  - Phosphorylation
MH  - Prehypertension/enzymology/etiology/physiopathology/*prevention & control
MH  - Rats, Inbred Dahl
MH  - Reactive Oxygen Species/*metabolism
MH  - Signal Transduction
MH  - Sodium Chloride, Dietary
MH  - Xanthophylls/pharmacology
MH  - Rats
OTO - NOTNLM
OT  - Astaxanthin
OT  - Hypothalamic paraventricular nucleus
OT  - Inflammatory cytokines
OT  - MAPK
OT  - Oxidative stress
OT  - Prehypertension
EDAT- 2021/09/20 06:00
MHDA- 2022/02/25 06:00
CRDT- 2021/09/19 20:54
PHST- 2021/06/11 00:00 [received]
PHST- 2021/09/08 00:00 [accepted]
PHST- 2021/09/20 06:00 [pubmed]
PHST- 2022/02/25 06:00 [medline]
PHST- 2021/09/19 20:54 [entrez]
AID - 10.1007/s12012-021-09695-6 [pii]
AID - 10.1007/s12012-021-09695-6 [doi]
PST - ppublish
SO  - Cardiovasc Toxicol. 2021 Dec;21(12):1045-1057. doi: 10.1007/s12012-021-09695-6. 
      Epub 2021 Sep 18.