PMID- 34539810
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220426
IS  - 1746-0794 (Print)
IS  - 1746-0808 (Electronic)
IS  - 1746-0794 (Linking)
VI  - 16
IP  - 9
DP  - 2021 Sep
TI  - Serum biochemical parameters as a surrogate marker for chest computed tomography 
      in children with COVID-19.
PG  - 601-609
LID - 10.2217/fvl-2021-0118 [doi]
AB  - AIM: This study aimed to investigate whether serum biochemical parameters can be 
      used as a surrogate for chest computed tomography (CT) in the diagnosis of 
      COVID-19 in pediatric patients. MATERIALS & METHODS: We evaluated potential 
      associations between various serum biochemical markers and the COVID-reporting 
      and data system (RADS) pneumonia grading system in 53 individuals with confirmed 
      COVID-19. RESULTS: A total of 28 chest CT scans (52.8%) were abnormal. Patients 
      with confirmed COVID-19 on CT showed a statistically significant increase in 
      lactate dehydrogenase (186.4 +/- 56.5 vs 228.4 +/- 60.6; p = 0.01), which was 
      significantly correlated with the COVID-RADS pneumonia grading system. 
      CONCLUSION: Lactate dehydrogenase can be used as a surrogate marker for chest CT 
      in children with COVID-19. This can reduce exposure to ionizing radiation during 
      initial diagnostic procedures in children with suspected COVID-19 pneumonia.
CI  - (c) 2021 Future Medicine Ltd.
FAU - Das, Karuna M
AU  - Das KM
AUID- ORCID: 0000-0002-4703-5433
AD  - Department of Radiology, CMHS, UAEU, Al Ain, UAE.
FAU - Singh, Rajvir
AU  - Singh R
AD  - Department of Biostatistics, AIIMS, New Delhi, India.
FAU - Subramanya, Sandeep
AU  - Subramanya S
AD  - Department of Physiology, CMHS, UAEU, Al Ain, UAE.
FAU - Ojha, Shreesh Kumar
AU  - Ojha SK
AD  - Department of Pharmacology, CMHS, UAEU, Al Ain, UAE.
FAU - Almansoori, Taleb
AU  - Almansoori T
AD  - Department of Radiology, CMHS, UAEU, Al Ain, UAE.
FAU - Gokhale, Dilip
AU  - Gokhale D
AD  - Department of Radiology, Tawam Hospital, Al Ain, UAE.
FAU - Alkoteesh, Jamal Aldeen
AU  - Alkoteesh JA
AD  - Department of Radiology, Tawam Hospital, Al Ain, UAE.
LA  - eng
PT  - Journal Article
DEP - 20210902
PL  - England
TA  - Future Virol
JT  - Future virology
JID - 101278124
PMC - PMC8439343
OTO - NOTNLM
OT  - COVID-19
OT  - Chest CT
OT  - LDH
OT  - serum ferritin
COIS- Financial & competing interests disclosure The authors have no relevant 
      affiliations or financial involvement with any organization or entity with a 
      financial interest in or financial conflict with the subject matter or materials 
      discussed in the manuscript. This includes employment, consultancies, honoraria, 
      stock ownership or options, expert testimony, grants or patents received or 
      pending, or royalties. Enago editing services were used in the production of the 
      manuscript and were funded by the United Arab Emirates University finance 
      department.
EDAT- 2021/09/21 06:00
MHDA- 2021/09/21 06:01
PMCR- 2021/09/02
CRDT- 2021/09/20 06:04
PHST- 2021/05/28 00:00 [received]
PHST- 2021/08/18 00:00 [accepted]
PHST- 2021/09/20 06:04 [entrez]
PHST- 2021/09/21 06:00 [pubmed]
PHST- 2021/09/21 06:01 [medline]
PHST- 2021/09/02 00:00 [pmc-release]
AID - 10.2217/fvl-2021-0118 [doi]
PST - ppublish
SO  - Future Virol. 2021 Sep;16(9):601-609. doi: 10.2217/fvl-2021-0118. Epub 2021 Sep 
      2.