PMID- 34540963
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210921
IS  - 2307-8960 (Print)
IS  - 2307-8960 (Electronic)
IS  - 2307-8960 (Linking)
VI  - 9
IP  - 24
DP  - 2021 Aug 26
TI  - Tuberous sclerosis complex-lymphangioleiomyomatosis involving several visceral 
      organs: A case report.
PG  - 7085-7091
LID - 10.12998/wjcc.v9.i24.7085 [doi]
AB  - BACKGROUND: Lymphangioleiomyomatosis (LAM) is a rare cystic lung disease 
      characterized by the proliferation, metastasis, and infiltration of smooth muscle 
      cells in the lung and other tissues, which can be associated with tuberous 
      sclerosis complex (TSC). The disorder of TSC has a variable expression, and there 
      is great phenotypic variability. CASE SUMMARY: A 32-year-old Chinese woman with a 
      history of multiple renal angioleiomyolipoma presented with a productive cough 
      persisting for over 2 wk. High-resolution chest computed tomography revealed 
      interstitial changes, multiple pulmonary bullae, bilateral pulmonary nodules, and 
      multiple fat density areas of the inferior mediastinum. Conventional and contrast 
      ultrasonography revealed multiple high echogenic masses of the liver, kidneys, 
      retroperitoneum, and inferior mediastinum. These masses were diagnosed as 
      angiomyolipomas. Pathology through thoracoscopic lung biopsy confirmed LAM. 
      Furthermore, high-throughput genome sequencing of peripheral blood DNA confirmed 
      the presence of a heterozygous mutation, c.1831C>T (p.Arg611Trp), of the TSC2 
      gene. The patient was diagnosed with TSC-LAM. CONCLUSION: We highlight a rare 
      case of TSC-LAM and the first report of a mediastinum lymphangioleiomyoma 
      associated with TSC-LAM.
CI  - (c)The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights 
      reserved.
FAU - Chen, Hong-Bin
AU  - Chen HB
AD  - Department of Pulmonary and Critical Care Medicine, Renmin Hospital of Wuhan 
      University, Wuhan 430060, Hubei Province, China.
FAU - Xu, Xiao-Hong
AU  - Xu XH
AD  - Department of Pulmonary and Critical Care Medicine, People's Hospital of 
      Hanchuan, Hanchuan 431600, Hubei Province, China.
FAU - Yu, Cai-Gui
AU  - Yu CG
AD  - Department of Echocardiography, Renmin Hospital of Wuhan University, Wuhan 
      430060, Hubei Province, China.
FAU - Wan, Meng-Ting
AU  - Wan MT
AD  - Department of Echocardiography, Renmin Hospital of Wuhan University, Wuhan 
      430060, Hubei Province, China.
FAU - Feng, Chuang-Li
AU  - Feng CL
AD  - Department of Echocardiography, Renmin Hospital of Wuhan University, Wuhan 
      430060, Hubei Province, China.
FAU - Zhao, Zhi-Yu
AU  - Zhao ZY
AD  - Department of Echocardiography, Renmin Hospital of Wuhan University, Wuhan 
      430060, Hubei Province, China.
FAU - Mei, Dan-E
AU  - Mei DE
AD  - Department of Echocardiography, Renmin Hospital of Wuhan University, Wuhan 
      430060, Hubei Province, China.
FAU - Chen, Jin-Ling
AU  - Chen JL
AD  - Department of Echocardiography, Renmin Hospital of Wuhan University, Wuhan 
      430060, Hubei Province, China. 77810848@qq.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - United States
TA  - World J Clin Cases
JT  - World journal of clinical cases
JID - 101618806
PMC - PMC8409179
OTO - NOTNLM
OT  - Angioleiomyolipoma
OT  - Case report
OT  - Contrast ultrasonography
OT  - High-resolution chest computed tomography
OT  - Lymphangioleiomyomatosis
OT  - Tuberous sclerosis complex
COIS- Conflict-of-interest statement: The authors declare that they have no conflicts 
      of interest to report.
EDAT- 2021/09/21 06:00
MHDA- 2021/09/21 06:01
PMCR- 2021/08/26
CRDT- 2021/09/20 06:15
PHST- 2021/04/29 00:00 [received]
PHST- 2021/05/30 00:00 [revised]
PHST- 2021/07/02 00:00 [accepted]
PHST- 2021/09/20 06:15 [entrez]
PHST- 2021/09/21 06:00 [pubmed]
PHST- 2021/09/21 06:01 [medline]
PHST- 2021/08/26 00:00 [pmc-release]
AID - 10.12998/wjcc.v9.i24.7085 [doi]
PST - ppublish
SO  - World J Clin Cases. 2021 Aug 26;9(24):7085-7091. doi: 10.12998/wjcc.v9.i24.7085.