PMID- 34542037
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20211125
IS  - 1878-6448 (Electronic)
IS  - 1053-8135 (Linking)
VI  - 49
IP  - 3
DP  - 2021
TI  - Predictive models for independence after stroke rehabilitation: Maugeri external 
      validation and development of a new model.
PG  - 415-424
LID - 10.3233/NRE-201619 [doi]
AB  - BACKGROUND: Many efforts have been devoted to identify predictors of functional 
      outcomes after stroke rehabilitation. Though extensively recommended, there are 
      very few external validation studies. OBJECTIVE: To externally validate two 
      predictive models (Maugeri model 1 and model 2) and to develop a new model (model 
      3) that estimate the probability of achieving improvement in physical functioning 
      (primary outcome) and a level of independence requiring no more than supervision 
      (secondary outcome) after stroke rehabilitation. METHODS: We used multivariable 
      logistic regression analysis for validation and development. Main outcome 
      measures were: Functional Independence Measure (FIM) (primary outcome), 
      Functional Independence Staging (FIS) (secondary outcome) and Minimal Clinically 
      Important Difference (MCID). RESULTS: Patients with stroke admitted to a 
      rehabilitation center from 2006 to 2019 were retrospectively studied (N = 710). 
      Validation of Maugeri models confirmed very good discrimination: for model 1 
      AUC = 0.873 (0.833-0.915) and model 2 AUC = 0.803 (0.749-0.857). The 
      Hosmer-Lemeshow chi2 was 6.07(p = 0.63) and 8.91(p = 0.34) respectively. Model 3 
      yielded an AUC = 0.894 (0.857-0.929) (primary outcome) and an AUC = 0.769 
      (0.714-0.825) (MCID). CONCLUSIONS: Discriminative power of both Maugeri models 
      was externally confirmed (in a 20 years younger population) and a new model 
      (incorporating aphasia) was developed outperforming Maugeri models in primary 
      outcome and MCID.
FAU - Garcia-Rudolph, Alejandro
AU  - Garcia-Rudolph A
AD  - Department of Research and Innovation, Institut Guttmann, Institut Universitari 
      de Neurorehabilitacio adscrit a la UAB, Badalona, Barcelona, Spain.
AD  - Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain.
AD  - Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 
      Barcelona, Spain.
FAU - Bernabeu, Montserrat
AU  - Bernabeu M
AD  - Department of Research and Innovation, Institut Guttmann, Institut Universitari 
      de Neurorehabilitacio adscrit a la UAB, Badalona, Barcelona, Spain.
AD  - Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain.
AD  - Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 
      Barcelona, Spain.
FAU - Cegarra, Blanca
AU  - Cegarra B
AD  - Department of Research and Innovation, Institut Guttmann, Institut Universitari 
      de Neurorehabilitacio adscrit a la UAB, Badalona, Barcelona, Spain.
AD  - Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain.
AD  - Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 
      Barcelona, Spain.
FAU - Sauri, Joan
AU  - Sauri J
AD  - Department of Research and Innovation, Institut Guttmann, Institut Universitari 
      de Neurorehabilitacio adscrit a la UAB, Badalona, Barcelona, Spain.
AD  - Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain.
AD  - Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 
      Barcelona, Spain.
FAU - Madai, Vince Istvan
AU  - Madai VI
AD  - CLAIM Charite Lab for AI in Medicine, Charite Universitatsmedizin Berlin, Berlin, 
      Germany.
AD  - QUEST Center for Transforming Biomedical Research, Berlin Institute of Health 
      (BIH), Charite Universitatsmedizin Berlin, Berlin, Germany.
AD  - School of Computing and Digital Technology, Faculty of Computing, Engineering and 
      the Built Environment, Birmingham City University, Birmingham, United Kingdom.
FAU - Frey, Dietmar
AU  - Frey D
AD  - CLAIM Charite Lab for AI in Medicine, Charite Universitatsmedizin Berlin, Berlin, 
      Germany.
FAU - Opisso, Eloy
AU  - Opisso E
AD  - Department of Research and Innovation, Institut Guttmann, Institut Universitari 
      de Neurorehabilitacio adscrit a la UAB, Badalona, Barcelona, Spain.
AD  - Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain.
AD  - Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 
      Barcelona, Spain.
FAU - Tormos, Josep Maria
AU  - Tormos JM
AD  - Department of Research and Innovation, Institut Guttmann, Institut Universitari 
      de Neurorehabilitacio adscrit a la UAB, Badalona, Barcelona, Spain.
AD  - Universitat Autonoma de Barcelona, Cerdanyola del Valles, Spain.
AD  - Fundacio Institut d'Investigacio en Ciencies de la Salut Germans Trias i Pujol, 
      Barcelona, Spain.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - NeuroRehabilitation
JT  - NeuroRehabilitation
JID - 9113791
SB  - IM
MH  - Activities of Daily Living
MH  - *Aphasia
MH  - Humans
MH  - Recovery of Function
MH  - Rehabilitation Centers
MH  - Retrospective Studies
MH  - *Stroke
MH  - *Stroke Rehabilitation
OTO - NOTNLM
OT  - Stroke rehabilitation
OT  - activities of daily living
OT  - aphasia
OT  - predictors
EDAT- 2021/09/21 06:00
MHDA- 2021/11/26 06:00
CRDT- 2021/09/20 08:50
PHST- 2021/09/21 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/09/20 08:50 [entrez]
AID - NRE201619 [pii]
AID - 10.3233/NRE-201619 [doi]
PST - ppublish
SO  - NeuroRehabilitation. 2021;49(3):415-424. doi: 10.3233/NRE-201619.