PMID- 34542169
OWN - NLM
STAT- MEDLINE
DCOM- 20220819
LR  - 20220823
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 132
IP  - 9
DP  - 2022 Sep
TI  - Persistent Cough as a Predictor of Poor Responsiveness in Asthma Patients.
PG  - 1719-1722
LID - 10.1002/lary.29865 [doi]
AB  - OBJECTIVES/HYPOTHESIS: The aim of this study is to establish a correlation 
      between persistent cough (PC) and asthma diagnosis and its severity. We 
      hypothesize that patients with past or current diagnosis of PC may have more 
      severe asthma diagnosis and thus poor responsiveness to treatment. STUDY DESIGN: 
      Retrospective chart review. METHODS: A retrospective review was performed on 699 
      charts that had a positive immunoglobulin E (IgE) allergy blood test between 2014 
      and 2018, and a positive asthma diagnosis. Patient demographics and asthma 
      severity parameters such as number of clinic and emergency department (ED) 
      visits, asthma treatment, and number of medications were recorded, as well as PC 
      diagnosis. Logistic regressions were used to analyze the likelihood of severe 
      asthma diagnosis in patients with PC. RESULTS: A total of 55% of patients were 
      treated with oral corticosteroids in the PC group, compared to 41% in those 
      without (P < .001). The mean number of hospitalizations from the ED was higher 
      for patients with PC 0.65 (2.47) versus 0.38 (1.18) P < .05. Patients with asthma 
      and PC, positive to lamb's quarter 2.92 (95% confidence interval [CI] 1.63, 5.22; 
      P < .001), showed a higher likelihood of ED visits. Positivity to cat dander 2.09 
      (95% CI 1.03, 4.59; P < .05), lamb's quarter 2.96 (95% CI 1.50, 5.79; P < .002), 
      dog dander 3.37 (95% CI 1.54, 8.45; P < .004) showed a higher likelihood of 
      hospitalizations due to asthma. CONCLUSION: Patients with PC, especially those 
      with a positive IgE allergy class test to cat dander, dog dander, house dust, 
      Alternaria tenuis, or lamb's quarter can have a more severe asthmatic 
      presentation. LEVEL OF EVIDENCE: 3 Laryngoscope, 132:1719-1722, 2022.
CI  - (c) 2021 The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Amador, Eulalia M
AU  - Amador EM
AUID- ORCID: 0000-0002-8904-3132
AD  - Lerner Research Insititute, Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A.
FAU - Cabrera, Claudia I
AU  - Cabrera CI
AUID- ORCID: 0000-0002-0645-8130
AD  - Lerner Research Insititute, Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A.
FAU - Benninger, Michael S
AU  - Benninger MS
AUID- ORCID: 0000-0003-1908-397X
AD  - Lerner Research Insititute, Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A.
AD  - Department of Otolaryngology-Head and Neck Surgery, Cleveland Clinic Lerner 
      College of Medicine, Head and Neck Institute, Cleveland, Ohio, U.S.A.
LA  - eng
PT  - Journal Article
DEP - 20210920
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
RN  - 0 (Allergens)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Allergens
MH  - *Asthma/complications/diagnosis
MH  - *Cough/etiology
MH  - Humans
MH  - Immunoglobulin E
MH  - Retrospective Studies
OTO - NOTNLM
OT  - Persistent cough
OT  - asthma
OT  - phenotype
EDAT- 2021/09/21 06:00
MHDA- 2022/08/20 06:00
CRDT- 2021/09/20 08:53
PHST- 2021/08/22 00:00 [revised]
PHST- 2021/03/12 00:00 [received]
PHST- 2021/09/09 00:00 [accepted]
PHST- 2021/09/21 06:00 [pubmed]
PHST- 2022/08/20 06:00 [medline]
PHST- 2021/09/20 08:53 [entrez]
AID - 10.1002/lary.29865 [doi]
PST - ppublish
SO  - Laryngoscope. 2022 Sep;132(9):1719-1722. doi: 10.1002/lary.29865. Epub 2021 Sep 
      20.