PMID- 34542898
OWN - NLM
STAT- MEDLINE
DCOM- 20220113
LR  - 20220113
IS  - 2651-5032 (Electronic)
IS  - 1019-5149 (Linking)
VI  - 32
IP  - 1
DP  - 2022
TI  - Diffusion-Weighted Imaging of Brain Metastasis: Correlation of MRI Parameters 
      with Histologic Type.
PG  - 58-68
LID - 10.5137/1019-5149.JTN.32084-20.4 [doi]
AB  - AIM: To compare the diffusion properties of brain metastases as imaging 
      biomarkers in various types of tumours, to determine their histology and origin. 
      MATERIAL AND METHODS: Magnetic Resonance Imaging (MRI) and diffusion-weighted 
      imaging (DWI) were used to retrospectively study the data of 143 patients 
      suffering from brain metastases. Four categories of primary tumours with 
      metastases to the brain were included: lung carcinoma (n=102, 71.3%); breast 
      carcinoma (n=27, 18.8%); colon carcinoma (n=8, 5.6%); and others (n=6, 4.2%). The 
      Apparent Diffusion Coefficient (ADCmin ) values, as well as the normalised ADC 
      ratio (nADC), were determined. The lesions on the DWI were categorised as 
      follows: type 1, with negative findings on DWI; type 2, which were isointense 
      with the normal cortical grey matter; type 3, which were hyperintense compared to 
      the normal cortical grey matter. RESULTS: The diffusion type, mean ADCmin, and 
      mean nADC showed statistically significant differences in different types of 
      metastases. In the subgroup analysis, it was found that type 3 was the diffusion 
      type found most extensively in the brain metastases of small cell carcinoma 
      (SCLC) (n=52, 65.8%, p < 0.000). Furthermore, the mean ADCmin and nADC values 
      were the least for the brain metastases of the SCLC (552.0 +/- 134.2 and nADC = 0.8 
      +/- 0.1, p < 0.000, respectively). The value of the mean ADCmin was low in the 
      human epidermal growth factor receptor 2 (HER-2) negative groups than in the 
      HER-2 positive groups at 786.8 +/- 299.1 vs 844.8 +/- 141.3 (p < 0.006). CONCLUSION: 
      Our findings indicated that there is a correlation between diffusion parameters 
      as imaging biomarkers of the solid component of brain metastases of primary 
      tumours and the tumour histology.
FAU - Ulu, Esra
AU  - Ulu E
AD  - Medicalpark Samsun Hospital, Department of Radiology, Samsun, Turkey.
FAU - Ozturk, Bahadir
AU  - Ozturk B
FAU - Atalay, Koksal
AU  - Atalay K
FAU - Okumus, Ibrahim Baris
AU  - Okumus IB
FAU - Erdem, Dilek
AU  - Erdem D
FAU - Gul, Mustafa Kemal
AU  - Gul MK
FAU - Terzi, Ozlem
AU  - Terzi O
LA  - eng
PT  - Journal Article
PL  - Turkey
TA  - Turk Neurosurg
JT  - Turkish neurosurgery
JID - 9423821
SB  - IM
MH  - *Brain Neoplasms/diagnostic imaging
MH  - Diffusion Magnetic Resonance Imaging
MH  - Humans
MH  - *Lung Neoplasms/diagnostic imaging
MH  - Magnetic Resonance Imaging
MH  - Retrospective Studies
EDAT- 2021/09/21 06:00
MHDA- 2022/01/14 06:00
CRDT- 2021/09/20 12:34
PHST- 2021/09/21 06:00 [pubmed]
PHST- 2022/01/14 06:00 [medline]
PHST- 2021/09/20 12:34 [entrez]
AID - 10.5137/1019-5149.JTN.32084-20.4 [doi]
PST - ppublish
SO  - Turk Neurosurg. 2022;32(1):58-68. doi: 10.5137/1019-5149.JTN.32084-20.4.