PMID- 34543780
OWN - NLM
STAT- MEDLINE
DCOM- 20220216
LR  - 20220216
IS  - 1878-3252 (Electronic)
IS  - 0946-672X (Linking)
VI  - 68
DP  - 2021 Dec
TI  - Association of newborn blood lead concentration with neurodevelopment outcome in 
      early infancy.
PG  - 126853
LID - S0946-672X(21)00143-7 [pii]
LID - 10.1016/j.jtemb.2021.126853 [doi]
AB  - BACKGROUND: In utero exposure to toxic metal substances can cause severe 
      neurodevelopmental deficits in developing fetus and infant. METHODS: We evaluated 
      the association of newborn umbilical cord blood lead concentration with early 
      neurodevelopmental performance (cognitive, receptive language, expressive 
      language, fine motor, gross motor and social-emotional development). The Bayley 
      Scale of Infants Developments-III (BSID-III) was used to perform neurodevelopment 
      outcomes at an average age of 6.5 months. In this prospective study, total of 167 
      mother-child pairs were enrolled from Western Rajasthan, India. Association 
      between risk factors of lead contamination and newborn umbilical cord blood lead 
      levels was observed. Multivariate regression was performed to see the association 
      of cord blood lead level with infant neurodevelopment outcome. RESULTS: The 
      obtained newborn umbilical cord blood lead concentration 5.0-10.5 mug/dL was 
      negatively associated with the sub-scale score of gross motor development 
      (beta-coefficient with 95 % CI; -0.29 (-5.0-0.11), p = 0.04). However, no 
      associations were found with the score of cognitive, language, gross motor, and 
      social-emotional development. The umbilical cord blood lead concentration <5.0 
      mug/dL was also not associated with the BSID-III scores. The mother's regular 
      intake of calcium supplements during the antenatal period was significantly 
      associated with a lower umbilical cord blood lead level (p-value 0.031). 
      CONCLUSION: The data suggest that newborn umbilical cord blood lead concentration 
      0.5-10.5 mug/dL has a negative association with early gross motor development 
      during infancy.
CI  - Copyright (c) 2021 Elsevier GmbH. All rights reserved.
FAU - Shekhawat, Dolat Singh
AU  - Shekhawat DS
AD  - Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, 
      342005, India. Electronic address: dolat.shek@gmail.com.
FAU - Janu, Vikash Chandra
AU  - Janu VC
AD  - WQMG/DEST Division, Defence Research and Development Organization, Jodhpur, 
      342011, India. Electronic address: Janu2k31@gmail.com.
FAU - Singh, Pratibha
AU  - Singh P
AD  - Department of Obstetrics and Gynaecology, All India Institute of Medical 
      Sciences, Jodhpur, 342005, India. Electronic address: drpratibha69@hotmail.com.
FAU - Sharma, Praveen
AU  - Sharma P
AD  - Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 
      342005, India. Electronic address: praveensharma55@gmail.com.
FAU - Singh, Kuldeep
AU  - Singh K
AD  - Department of Pediatrics, All India Institute of Medical Sciences, Jodhpur, 
      342005, India. Electronic address: singhk@aiimsjodhpur.edu.in.
LA  - eng
PT  - Journal Article
DEP - 20210901
PL  - Germany
TA  - J Trace Elem Med Biol
JT  - Journal of trace elements in medicine and biology : organ of the Society for 
      Minerals and Trace Elements (GMS)
JID - 9508274
RN  - 2P299V784P (Lead)
SB  - IM
MH  - Child Development
MH  - Diagnostic Tests, Routine
MH  - Female
MH  - *Fetal Blood
MH  - Humans
MH  - India
MH  - Infant
MH  - Infant, Newborn
MH  - *Lead
MH  - Pregnancy
MH  - Prospective Studies
OTO - NOTNLM
OT  - Infant
OT  - Lead
OT  - Neurodevelopment
OT  - Newborn
OT  - Umbilical cord blood
EDAT- 2021/09/21 06:00
MHDA- 2022/02/17 06:00
CRDT- 2021/09/20 20:16
PHST- 2021/03/15 00:00 [received]
PHST- 2021/07/24 00:00 [revised]
PHST- 2021/08/30 00:00 [accepted]
PHST- 2021/09/21 06:00 [pubmed]
PHST- 2022/02/17 06:00 [medline]
PHST- 2021/09/20 20:16 [entrez]
AID - S0946-672X(21)00143-7 [pii]
AID - 10.1016/j.jtemb.2021.126853 [doi]
PST - ppublish
SO  - J Trace Elem Med Biol. 2021 Dec;68:126853. doi: 10.1016/j.jtemb.2021.126853. Epub 
      2021 Sep 1.