PMID- 34544511
OWN - NLM
STAT- MEDLINE
DCOM- 20221221
LR  - 20221222
IS  - 1475-2662 (Electronic)
IS  - 0007-1145 (Linking)
VI  - 128
IP  - 4
DP  - 2022 Aug 28
TI  - The effect of probiotics/synbiotics supplementation on renal and liver biomarkers 
      in patients with type 2 diabetes: a systematic review and meta-analysis of 
      randomised controlled trials.
PG  - 625-635
LID - 10.1017/S0007114521003780 [doi]
AB  - Despite the apparent beneficial effects of probiotics/synbiotics on glucose 
      haemostasis, lipid profile and inflammatory responses, it is not clear whether 
      these beneficial effects also impact renal and hepatic function in diabetes. 
      Therefore, we sought to assess the effect of probiotics/synbiotics 
      supplementation on renal and liver biomarkers in adults with type 2 diabetes 
      mellitus (T2DM) using a systematic review and meta-analysis of randomised 
      controlled trials (RCT). PubMed, Scopus, Web of Science and Cochrane Library were 
      systematically searched, up to February 2021. The pooled weighted mean difference 
      (WMD) was estimated using a random-effects model. The methodological quality of 
      studies, as well as certainty of evidence, was assessed using standard scales. 
      Fifteen related trials were identified. Meta-analysis of six trials, involving 
      426 participants, indicated that probiotics/synbiotics supplementation reduced 
      serum levels of creatinine (WMD = -0.10 mg/dl, 95 % CI -0.20, -0.00; P = 0.01; I 
      (2) = 87.7 %; P-heterogeneity < 0.001), without any significant effect on blood 
      urea nitrogen (BUN), glomerular filtration rate or microalbuminuria. No 
      significant improvement was found on liver biomarkers following 
      probiotics/synbiotics supplementation. The subgroup analysis showed a significant 
      improvement in BUN when follow-up duration lasted for 12 weeks or more (WMD = 
      -1.215 mg/dl, 95 % CI -1.933, -0.496; P = 0.001) and in creatinine levels in 
      patients with renal dysfunction (WMD = -0.209 mg/dl, 95 % CI -0.322, -0.096; P < 
      0.001). Our results are insufficient to advocate the use of probiotics/synbiotics 
      for improving renal or liver function in patients with T2DM. Indeed, due to the 
      low certainty of evidence, these findings need to be affirmed in further 
      high-quality RCT.
FAU - Abdollahi, Shima
AU  - Abdollahi S
AD  - Department of Nutrition and Public Health, School of Public Health, North 
      Khorasan University of Medical Sciences, Bojnurd, Iran.
FAU - Meshkini, Fatemeh
AU  - Meshkini F
AD  - Department of Biochemistry, School of Medicine, Shahid Sadoughi University of 
      Medical Sciences, Yazd, Iran.
AD  - Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, 
      Iran.
FAU - Clark, Cain C T
AU  - Clark CCT
AD  - Centre for Intelligent Healthcare, Coventry University, CoventryCV1 5FB, UK.
FAU - Heshmati, Javad
AU  - Heshmati J
AUID- ORCID: 0000-0002-2676-0185
AD  - Songhor Healthcare Center, Kermanshah University of Medical Sciences, Kermanshah, 
      Iran.
FAU - Soltani, Sepideh
AU  - Soltani S
AD  - Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical 
      Sciences, Yazd, Iran.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Systematic Review
DEP - 20210921
PL  - England
TA  - Br J Nutr
JT  - The British journal of nutrition
JID - 0372547
RN  - AYI8EX34EU (Creatinine)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Adult
MH  - Humans
MH  - *Synbiotics
MH  - Creatinine
MH  - *Probiotics
MH  - Liver
MH  - *Diabetes Mellitus, Type 2
MH  - Biomarkers
MH  - Randomized Controlled Trials as Topic
OTO - NOTNLM
OT  - Glomerular filtration rate
OT  - Kidney
OT  - Liver
OT  - Meta-analysis
OT  - Probiotic
OT  - Synbiotics
OT  - Type 2 diabetes
EDAT- 2021/09/22 06:00
MHDA- 2022/12/22 06:00
CRDT- 2021/09/21 05:40
PHST- 2021/09/22 06:00 [pubmed]
PHST- 2022/12/22 06:00 [medline]
PHST- 2021/09/21 05:40 [entrez]
AID - S0007114521003780 [pii]
AID - 10.1017/S0007114521003780 [doi]
PST - ppublish
SO  - Br J Nutr. 2022 Aug 28;128(4):625-635. doi: 10.1017/S0007114521003780. Epub 2021 
      Sep 21.