PMID- 34544554
OWN - NLM
STAT- MEDLINE
DCOM- 20220113
LR  - 20220113
IS  - 1988-561X (Electronic)
IS  - 1699-8855 (Linking)
VI  - 54
IP  - 4
DP  - 2021 Oct-Dec
TI  - Adenoid cystic carcinoma and basaloid carcinoma of the breast: A 
      clinicopathological study.
PG  - 242-249
LID - S1699-8855(20)30110-0 [pii]
LID - 10.1016/j.patol.2020.09.005 [doi]
AB  - Adenoid cystic carcinoma of the breast (ACCB) is a rare triple negative tumor 
      (TNT) with an excellent prognosis in most cases. Three different histologic types 
      are recognized: classic ACCB, solid basaloid ACCB (SB-ACCB), and ACCB with 
      high-grade transformation. A majority of these tumors show characteristic 
      molecular and immunohistochemical (IHC) features, with fusion of MYB and NFIB 
      genes and overexpression of MYB, respectively. Basaloid carcinomas of the breast 
      (BCB) are infrequently described. They resemble SB-ACCB and TNT of no special 
      type (TNT-NST). We have studied the clinicopathological features of 17 ACCB and 9 
      BCB, investigating the expression of MYB by IHC and the rearrangements of MYB by 
      fluorescence in situ hybridization (FISH). MYB was expressed by IHC in 15 ACCB 
      and in 3 BCB. MYB FISH detected rearrangements in 11 ACCB and in 2 BCB. After a 
      mean follow-up of 90 months, with a range of 12-204 months, 2 patients with ACCB 
      with high-grade transformation and 1 patient with BCB developed metastases and 
      died of disease. In summary, most ACCB have a good prognosis, but tumors with 
      adverse histopathological features may metastasize. BCB may overlap with ACCB and 
      TNT-NST, and their prognosis should be further studied.
CI  - Copyright (c) 2020 Sociedad Espanola de Anatomia Patologica. Publicado por Elsevier 
      Espana, S.L.U. All rights reserved.
FAU - Marco, Vicente
AU  - Marco V
AD  - Hospital Quironsalud Barcelona, Pathology, Barcelona, Spain. Electronic address: 
      vmarcomolina@gmail.com.
FAU - Garcia, Felip
AU  - Garcia F
AD  - Hospital Quironsalud Barcelona, Pathology, Barcelona, Spain.
FAU - Rubio, Isabel T
AU  - Rubio IT
AD  - Hospital Quironsalud Barcelona, IOB, Barcelona, Spain.
FAU - Soler, Teresa
AU  - Soler T
AD  - Hospital Universitari Bellvitge/ICO/IDIBELL, Hospitalet de Llobregat, Spain.
FAU - Ferrazza, Laura
AU  - Ferrazza L
AD  - Hospital Universitari Bellvitge/ICO/IDIBELL, Hospitalet de Llobregat, Spain.
FAU - Roig, Ignasi
AU  - Roig I
AD  - Consorci Sanitari de Terrassa, Pathology, Terrassa, Spain.
FAU - Mendez, Inmaculada
AU  - Mendez I
AD  - Hospital General de Granollers, Pathology, Granollers, Spain.
FAU - Andreu, Xavier
AU  - Andreu X
AD  - Hospital Parc Tauli, Pathology, Sabadell, Spain.
FAU - Minguez, Clarisa Gonzalez
AU  - Minguez CG
AD  - Hospital Mutua de Terrassa, Pathology, Terrassa, Spain.
FAU - Tresserra, Francesc
AU  - Tresserra F
AD  - Hospital Universitario Quiron Dexeus, Pathology, Barcelona, Spain.
LA  - eng
PT  - Journal Article
DEP - 20201231
PL  - Spain
TA  - Rev Esp Patol
JT  - Revista espanola de patologia : publicacion oficial de la Sociedad Espanola de 
      Anatomia Patologica y de la Sociedad Espanola de Citologia
JID - 100885154
SB  - IM
MH  - Breast
MH  - *Breast Neoplasms
MH  - *Carcinoma, Adenoid Cystic/genetics
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Prognosis
OTO - NOTNLM
OT  - Breast basaloid carcinoma
OT  - Carcinoma adenoide quistico basaloide solido
OT  - Carcinoma adenoide quistico de alto grado
OT  - Carcinoma adenoide quistico de mama
OT  - Carcinoma basaloide de mama
OT  - High-grade adenoid cystic carcinoma
OT  - Mammary adenoid cystic carcinoma
OT  - Solid basaloid adenoid cystic carcinoma
EDAT- 2021/09/22 06:00
MHDA- 2022/01/14 06:00
CRDT- 2021/09/21 05:42
PHST- 2020/05/31 00:00 [received]
PHST- 2020/08/05 00:00 [revised]
PHST- 2020/09/15 00:00 [accepted]
PHST- 2021/09/21 05:42 [entrez]
PHST- 2021/09/22 06:00 [pubmed]
PHST- 2022/01/14 06:00 [medline]
AID - S1699-8855(20)30110-0 [pii]
AID - 10.1016/j.patol.2020.09.005 [doi]
PST - ppublish
SO  - Rev Esp Patol. 2021 Oct-Dec;54(4):242-249. doi: 10.1016/j.patol.2020.09.005. Epub 
      2020 Dec 31.