PMID- 34545921
OWN - NLM
STAT- MEDLINE
DCOM- 20211125
LR  - 20240317
IS  - 1760-4788 (Electronic)
IS  - 1279-7707 (Print)
IS  - 1279-7707 (Linking)
VI  - 25
IP  - 8
DP  - 2021
TI  - Intrinsic Capacity as a Determinant of Physical Resilience in Older Adults.
PG  - 1006-1011
LID - 10.1007/s12603-021-1629-z [doi]
AB  - The traditional disease-oriented model of healthcare is inadequate to address the 
      needs of the older population. Greater attention should be given to strategies 
      that promote healthy aging. Recently proposed constructs of intrinsic capacity 
      (IC) and physical resilience (PR) hold great potential to reshape geriatric 
      medicine and aging research. These constructs accentuate the positive health 
      attributes of older people in contrast to the popular frailty construct that is 
      centered on functional deficits. IC was introduced by the World Health 
      Organization (WHO) as a composite of all the physical and mental capacities. WHO 
      has emphasized enhancement of IC throughout the life course so as to maintain 
      functional ability in old age. PR, recently highlighted by the National Institute 
      on Aging, is the ability to successfully cope with stressors. High levels of 
      resilience can result in desirable clinical and functional outcomes after 
      stressors. Therefore, it is important to understand the underlying physiology of 
      PR and the risk factors contributing to diminished PR. The main goal of this 
      article is to explore the potential relationship between IC and PR. Based on a 
      classical theory of aging, we postulate that IC is a determinant of PR and is 
      also a high-level integrative measure of physiologic reserve which is the 
      fundamental factor underlying one's ability to withstand stressors. A major 
      implication of our postulates is that even though IC is only one of the many 
      determinants of PR, it could serve as an important intervenable target for 
      enhancing resilience in older adults.
FAU - Chhetri, J K
AU  - Chhetri JK
AD  - Dr. Jagadish K. Chhetri M.D, Xuanwu Hospital of Capital Medical University, No. 
      45 Changchun Street, Xicheng District, Beijing 100053, China. E-mail: 
      chhetri_jk@hotmail.com, Twitter: @JagadishChhetri; Dr. Ravi Varadhan Phd, PhD, 
      Johns Hopkins School of Medicine, 550 N. Broadway, Suite 1103-A, Baltimore, MD 
      21205, USA, E-mail: ravi.varadhan@jhu.edu, Twitter: @Tyche63.
FAU - Xue, Q-L
AU  - Xue QL
FAU - Ma, L
AU  - Ma L
FAU - Chan, P
AU  - Chan P
FAU - Varadhan, R
AU  - Varadhan R
LA  - eng
GR  - P30 AG021334/AG/NIA NIH HHS/United States
GR  - UH2 AG056933/AG/NIA NIH HHS/United States
GR  - UH3 AG056933/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - J Nutr Health Aging
JT  - The journal of nutrition, health & aging
JID - 100893366
SB  - IM
MH  - Activities of Daily Living
MH  - Adaptation, Psychological
MH  - Aged
MH  - Aging
MH  - *Frailty
MH  - *Healthy Aging
MH  - Humans
PMC - PMC8035602
OTO - NOTNLM
OT  - Resilience
OT  - aging
OT  - frailty
OT  - integrated care
OT  - physiologic reserve
COIS- All authors declare no conflicts of interest.
EDAT- 2021/09/22 06:00
MHDA- 2021/11/26 06:00
PMCR- 2021/04/10
CRDT- 2021/09/21 08:45
PHST- 2021/09/21 08:45 [entrez]
PHST- 2021/09/22 06:00 [pubmed]
PHST- 2021/11/26 06:00 [medline]
PHST- 2021/04/10 00:00 [pmc-release]
AID - S1279-7707(23)00780-7 [pii]
AID - 1629 [pii]
AID - 10.1007/s12603-021-1629-z [doi]
PST - ppublish
SO  - J Nutr Health Aging. 2021;25(8):1006-1011. doi: 10.1007/s12603-021-1629-z.