PMID- 34546522 OWN - NLM STAT- MEDLINE DCOM- 20220727 LR - 20220727 IS - 1863-2491 (Electronic) IS - 1863-2483 (Linking) VI - 16 IP - 4 DP - 2022 Aug TI - A comparative study of anticoagulant/antiplatelet therapy among men undergoing robot-assisted radical prostatectomy: a prospective single institution study. PG - 849-857 LID - 10.1007/s11701-021-01308-2 [doi] AB - The present study aimed to assess the safety and efficacy of robot-assisted radical prostatectomy (RARP) in patients with prostate cancer (PCa) under anticoagulant (AC) and/or antiplatelet (AP) therapy, as compared to a control group, and to establish possible differences in postoperative-related morbidity. Data of all consecutive patients submitted to elective RARP for PCa from June 2017 to May 2020 at our institution were prospectively collected. Patients were divided according to the use of AC/AP therapy at surgery. The primary endpoint was to determine differences in 90-day postoperative complication rate, while secondary endpoints included differences in transfusion rate, readmission rate and postoperative oncological outcomes between the two groups. Sub-groups analysis was separately performed for patients undergoing pelvic lymphadenectomy and nerve-sparing procedures. Overall, 822 patients were included in the study and divided in 704 control-group patients (group A) and 118 patients under AC/AP therapy at surgery (group B). Despite the higher estimated blood loss between AC/AP takers and the control group, we did not find a significant difference in terms of 90-day postoperative complication rate, transfusion rate, readmission rate and postoperative oncological outcomes (all p > 0.05). In the cohort of patients undergoing nerve-sparing prostatectomy, a higher rate of complications and transfusions were found. At multivariate analysis, ASA score and ongoing medications were independently associated with complication in this sub-group. RARP can be safely and effectively performed in patients with PCa and ongoing AC/AP agents. Attention has to be paid in candidates for nerve-sparing procedures. CI - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag London Ltd., part of Springer Nature. FAU - Sforza, Simone AU - Sforza S AUID- ORCID: 0000-0001-8613-3995 AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. simone.sforza1988@gmail.com. FAU - Grosso, Antonio Andrea AU - Grosso AA AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. FAU - Di Maida, Fabrizio AU - Di Maida F AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. FAU - Viola, Lorenzo AU - Viola L AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. FAU - Tuccio, Agostino AU - Tuccio A AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. FAU - Mari, Andrea AU - Mari A AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. FAU - Cito, Gianmartin AU - Cito G AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. FAU - Cocci, Andrea AU - Cocci A AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. FAU - Carini, Marco AU - Carini M AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. FAU - Minervini, Andrea AU - Minervini A AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. FAU - Masieri, Lorenzo AU - Masieri L AD - Department of Experimental and Clinical Medicine, University of Florence-Unit of Oncologic Minimally-Invasive Urology and Andrology, Careggi Hospital, Largo Brambilla, 3, 70134, Florence, Italy. LA - eng PT - Journal Article DEP - 20210921 PL - England TA - J Robot Surg JT - Journal of robotic surgery JID - 101300401 RN - 0 (Anticoagulants) RN - 0 (Platelet Aggregation Inhibitors) SB - IM MH - Anticoagulants/therapeutic use MH - Humans MH - Male MH - Platelet Aggregation Inhibitors/therapeutic use MH - Postoperative Complications/etiology MH - Prospective Studies MH - Prostatectomy/methods MH - *Prostatic Neoplasms/drug therapy/surgery MH - *Robotic Surgical Procedures/methods MH - *Robotics MH - Treatment Outcome OTO - NOTNLM OT - Antiplatelet therapy OT - Comorbid patients OT - Prostate cancer OT - Radical prostatectomy OT - Robotic surgery EDAT- 2021/09/22 06:00 MHDA- 2022/07/28 06:00 CRDT- 2021/09/21 12:46 PHST- 2021/06/28 00:00 [received] PHST- 2021/09/06 00:00 [accepted] PHST- 2021/09/22 06:00 [pubmed] PHST- 2022/07/28 06:00 [medline] PHST- 2021/09/21 12:46 [entrez] AID - 10.1007/s11701-021-01308-2 [pii] AID - 10.1007/s11701-021-01308-2 [doi] PST - ppublish SO - J Robot Surg. 2022 Aug;16(4):849-857. doi: 10.1007/s11701-021-01308-2. Epub 2021 Sep 21.