PMID- 34546615
OWN - NLM
STAT- MEDLINE
DCOM- 20220404
LR  - 20220405
IS  - 1468-1331 (Electronic)
IS  - 1351-5101 (Linking)
VI  - 29
IP  - 1
DP  - 2022 Jan
TI  - Correlation analysis between regional homogeneity and executive dysfunction in 
      anti-N-methyl-D-aspartate receptor encephalitis patients.
PG  - 277-285
LID - 10.1111/ene.15119 [doi]
AB  - BACKGROUND AND PURPOSE: Anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis 
      is characterized by a range of cognitive impairments, especially in executive 
      function. Our study aims to identify the abnormal regional homogeneity (ReHo) in 
      anti-NMDAR encephalitis patients and its relationship with the executive 
      function. METHODS: Forty patients and 42 healthy volunteers undertook an 
      Attention Network Test and a resting-state functional magnetic resonance imaging 
      scan. ReHo analysis was performed to investigate the neuronal activity 
      synchronization in all subjects. Based on ReHo analysis, a multivariate pattern 
      analysis (MVPA) was carried out to identify the brain regions that differed the 
      most between the two groups. RESULTS: Compared to controls, the patients had 
      higher executive control scores (p < 0.05). The patients presented reduced ReHo 
      values in the bilateral posterior cerebellar lobe, anterior cerebellar lobe, 
      midbrain, bilateral caudate nucleus, right superior frontal gyrus, right middle 
      temporal gyrus, bilateral inferior parietal lobule and the left middle frontal 
      gyrus. The ReHo values of the bilateral inferior parietal lobule in patients were 
      found to be negatively associated with executive control scores. The 
      classification of patients and controls using MVPA had an accuracy of 76.83%, a 
      sensitivity of 82.50%, a specificity of 71.43% and the area under the curve was 
      0.83. CONCLUSIONS: Our study provides evidence of abnormal cerebral function in 
      anti-NMDAR encephalitis patients, which may contribute to unveiling the 
      neuropathological mechanisms of anti-NMDAR encephalitis and their influences on 
      executive dysfunction. The MVPA classifier, based on ReHo, is helpful in 
      identifying anti-NMDAR encephalitis patients from healthy controls.
CI  - (c) 2021 European Academy of Neurology.
FAU - Wu, Peirong
AU  - Wu P
AD  - Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 
      Nanning, China.
FAU - Pang, Xiaomin
AU  - Pang X
AD  - Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 
      Nanning, China.
FAU - Liang, Xiulin
AU  - Liang X
AD  - Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 
      Nanning, China.
FAU - Wei, Wutong
AU  - Wei W
AD  - Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 
      Nanning, China.
FAU - Li, Xinrong
AU  - Li X
AD  - Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 
      Nanning, China.
FAU - Zhao, Jingyuan
AU  - Zhao J
AD  - Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 
      Nanning, China.
FAU - Zheng, Jinou
AU  - Zheng J
AUID- ORCID: 0000-0002-7818-9160
AD  - Department of Neurology, First Affiliated Hospital of Guangxi Medical University, 
      Nanning, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211003
PL  - England
TA  - Eur J Neurol
JT  - European journal of neurology
JID - 9506311
SB  - IM
MH  - *Anti-N-Methyl-D-Aspartate Receptor Encephalitis/complications/diagnostic imaging
MH  - Brain/pathology
MH  - Brain Mapping/methods
MH  - *Cognitive Dysfunction/complications/etiology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
OTO - NOTNLM
OT  - anti-NMDAR encephalitis
OT  - executive dysfunction
OT  - multivariate pattern analysis
OT  - regional homogeneity
OT  - resting-state functional MRI
EDAT- 2021/09/22 06:00
MHDA- 2022/04/05 06:00
CRDT- 2021/09/21 12:50
PHST- 2021/07/19 00:00 [revised]
PHST- 2021/06/20 00:00 [received]
PHST- 2021/09/19 00:00 [accepted]
PHST- 2021/09/22 06:00 [pubmed]
PHST- 2022/04/05 06:00 [medline]
PHST- 2021/09/21 12:50 [entrez]
AID - 10.1111/ene.15119 [doi]
PST - ppublish
SO  - Eur J Neurol. 2022 Jan;29(1):277-285. doi: 10.1111/ene.15119. Epub 2021 Oct 3.