PMID- 34547156
OWN - NLM
STAT- MEDLINE
DCOM- 20211224
LR  - 20221005
IS  - 1399-3062 (Electronic)
IS  - 1398-2273 (Print)
IS  - 1398-2273 (Linking)
VI  - 23
IP  - 6
DP  - 2021 Dec
TI  - Long-term follow-up of SARS-CoV-2 recovered renal transplant recipients: A 
      single-center experience from India.
PG  - e13735
LID - 10.1111/tid.13735 [doi]
LID - e13735
AB  - INTRODUCTION: Follow-up studies of severe acute respiratory syndrome coronavirus 
      2 (SARS-CoV-2) in kidney transplant recipients (KTR) are scarcely reported. 
      METHODS: We studied 142 hospitalized KTR for a median (interquartile range) 
      follow-up of 9 (8-11) months who recovered from SARS-CoV-2 during May 2020 to Dec 
      2020. The outcomes were to assess persistent symptoms post-discharge; EuroQoL 
      visual analogue score (EQ-VAS); EuroQoL 5-dimension score (E5-QD-5L) score and 
      modified medical research dyspnea score (mMRC) at 1 month, 3-month, and beyond 6 
      months. Graft outcome was also analyzed. RESULTS: The age of the cohort was 43 
      (34-69) years and COVID-19 severity ranged from asymptomatic (4%), mild (50%), 
      moderate (35%) to severe (12%). The most common persistent symptom was fatigue 
      which significantly decreased in the follow-up (n = 45 [32.3] vs. 10 [7.4] vs. 4 
      [2.9]; p-value = 0.001) at 1-month, 3-month, and beyond 6 months respectively. 
      Decrement in the mean (standard deviation) EQ-VAS score from baseline was also 
      improved (28.6 [13] vs. 10.4 [12.5] vs. 7.5 [12.0]; p-value = 0.012). There was 
      significant improvement in all EQ-5D-5L scores in follow-up. There was no 
      deterioration in mMRC scores during the follow-up (n = 4, 3% vs. 7, 5% vs. 3, 2%; 
      p-value = 0.86). Cases requiring oxygen had significantly poorer overall scores 
      initially, but there was no difference at 6 months. All 10 graft losses had 
      oxygen requirement and chronic graft dysfunction at baseline. CONCLUSION: Our 
      initial assessment reports significant improvement in the quality of life in 
      follow-up. The majority recovered from allograft dysfunction. Further research is 
      warranted to study the full spectrum of follow-up.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Chauhan, Sanshriti
AU  - Chauhan S
AUID- ORCID: 0000-0001-7385-5614
AD  - Department of Nephrology and transplantation, IKDRC-ITS, Ahmedabad, Gujarat, 
      India.
FAU - Meshram, Hari Shankar
AU  - Meshram HS
AUID- ORCID: 0000-0001-9148-8168
AD  - Department of Nephrology and transplantation, IKDRC-ITS, Ahmedabad, Gujarat, 
      India.
FAU - Kute, Vivek
AU  - Kute V
AUID- ORCID: 0000-0001-6549-4505
AD  - Department of Nephrology and transplantation, IKDRC-ITS, Ahmedabad, Gujarat, 
      India.
FAU - Patel, Himanshu
AU  - Patel H
AUID- ORCID: 0000-0002-8922-0864
AD  - Department of Nephrology and transplantation, IKDRC-ITS, Ahmedabad, Gujarat, 
      India.
FAU - Desai, Sudeep
AU  - Desai S
AUID- ORCID: 0000-0001-5038-8857
AD  - Department of Nephrology and transplantation, IKDRC-ITS, Ahmedabad, Gujarat, 
      India.
FAU - Dave, Ruchir
AU  - Dave R
AUID- ORCID: 0000-0003-0569-7188
AD  - Department of Nephrology and transplantation, IKDRC-ITS, Ahmedabad, Gujarat, 
      India.
LA  - eng
PT  - Journal Article
DEP - 20211006
PL  - Denmark
TA  - Transpl Infect Dis
JT  - Transplant infectious disease : an official journal of the Transplantation 
      Society
JID - 100883688
SB  - IM
MH  - Adult
MH  - Aftercare
MH  - Aged
MH  - *COVID-19
MH  - Follow-Up Studies
MH  - Humans
MH  - *Kidney Transplantation/adverse effects
MH  - Middle Aged
MH  - Patient Discharge
MH  - Quality of Life
MH  - SARS-CoV-2
MH  - Transplant Recipients
PMC - PMC8646905
OTO - NOTNLM
OT  - COVID-19 recovered
OT  - follow-up
OT  - kidney transplantaion
OT  - post-COVID-19
OT  - quality of life
COIS- The authors declare that there is no conflict of interest that could be perceived 
      as prejudicing the impartiality of the research reported.
EDAT- 2021/09/22 06:00
MHDA- 2021/12/25 06:00
PMCR- 2021/10/06
CRDT- 2021/09/21 17:28
PHST- 2021/08/27 00:00 [revised]
PHST- 2021/07/27 00:00 [received]
PHST- 2021/09/01 00:00 [accepted]
PHST- 2021/09/22 06:00 [pubmed]
PHST- 2021/12/25 06:00 [medline]
PHST- 2021/09/21 17:28 [entrez]
PHST- 2021/10/06 00:00 [pmc-release]
AID - TID13735 [pii]
AID - 10.1111/tid.13735 [doi]
PST - ppublish
SO  - Transpl Infect Dis. 2021 Dec;23(6):e13735. doi: 10.1111/tid.13735. Epub 2021 Oct 
      6.