PMID- 34547775
OWN - NLM
STAT- MEDLINE
DCOM- 20210923
LR  - 20221001
IS  - 1833-3516 (Print)
IS  - 2209-1491 (Electronic)
IS  - 1833-3516 (Linking)
VI  - 51
IP  - 3
DP  - 2021 Sep 30
TI  - Long-term infant outcomes after hyperbaric oxygen treatment for acute carbon 
      monoxide poisoning during pregnancy.
PG  - 248-255
LID - 10.28920/dhm51.3.248-255 [doi]
AB  - INTRODUCTION: Carbon monoxide (CO) poisoning in pregnant women is linked to 
      foetal mortality of 36-67%. This study assessed long-term fetal outcomes 
      following hyperbaric oxygen treatment (HBOT) for acute CO poisoning in pregnant 
      women. The effects of clinical severity parameters and pregnancy trimester were 
      also analysed. METHODS: A retrospective review of 28 pregnant patients who 
      received HBOT for acute CO poisoning between January 2013-June 2016 was made. 
      Adverse events, birth week, birth weight-height, birth complications, and the age 
      of crawling, walking independently, talking (first words) of their children were 
      recorded. RESULTS: Twenty-eight singleton pregnancies were included. One fetus 
      was dead before HBOT. Three adverse events were reported: abortion, premature 
      birth, and limb malformation. All remaining patients (n = 24) delivered healthy 
      term infants and reported normal neurophysiological development. At final 
      interview the median age of babies was 34 (8-44) months and none had any 
      diagnosed disease. There was no relationship between clinical severity parameters 
      and long-term outcomes. However, the pregnancy trimester at the time of CO 
      poisoning had a significant relationship to birth weight (P = 0.029). Also, the 
      week of pregnancy at the time of the incident correlated with the age of walking 
      independently (P = 0.043, r = 0.436). CONCLUSIONS: This is the largest relevant 
      series and longest follow-up to date. Adverse outcomes were likely incidental 
      because the mothers' medical histories revealed alternative aetiologies. There 
      was no definite evidence of fetal morbidity or mortality after HBOT in this 
      study. HBOT may improve long-term fetal outcomes after in-utero CO poisoning 
      without complications.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Ozgok-Kangal, Kubra
AU  - Ozgok-Kangal K
AD  - Department of Undersea and Hyperbaric Medicine, Saglik Bilimleri Universitesi, 
      Gulhane Egitim ve Arastirma Hastanesi, Ankara, Turkey.
AD  - Dr Kubra Ozgok-Kangal, Gen Dr Tevfik Saglam Cad. SBU-Gulhane Egitim ve Arastirma 
      Hastanesi, Sualti Hekimligi ve Hiperbarik Tip Klinigi, Etlik, Ankara, Turkey, 
      ORCID: 0000-0002-2449-4821. kubra_ozgk@hotmail.com.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Carbon Monoxide Poisoning/therapy
MH  - Child
MH  - Child, Preschool
MH  - Female
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - Infant
MH  - Oxygen
MH  - Pregnancy
MH  - *Pregnancy Complications/therapy
MH  - Retrospective Studies
PMC - PMC8608441
OTO - NOTNLM
OT  - Fetal development
OT  - Hyperbaric medicine
OT  - Long-term adverse effects
OT  - Pregnancy outcome
OT  - Pregnancy trimesters
COIS- Conflict of interest and funding: nil
EDAT- 2021/09/22 06:00
MHDA- 2021/09/24 06:00
PMCR- 2022/09/30
CRDT- 2021/09/21 20:33
PHST- 2020/12/18 00:00 [received]
PHST- 2021/05/16 00:00 [accepted]
PHST- 2021/09/21 20:33 [entrez]
PHST- 2021/09/22 06:00 [pubmed]
PHST- 2021/09/24 06:00 [medline]
PHST- 2022/09/30 00:00 [pmc-release]
AID - 10.28920/dhm51.3.248-255 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2021 Sep 30;51(3):248-255. doi: 10.28920/dhm51.3.248-255.