PMID- 34547780
OWN - NLM
STAT- MEDLINE
DCOM- 20210923
LR  - 20221001
IS  - 1833-3516 (Print)
IS  - 2209-1491 (Electronic)
IS  - 1833-3516 (Linking)
VI  - 51
IP  - 3
DP  - 2021 Sep 30
TI  - Perioperative hyperbaric oxygen treatment and postoperative complications 
      following secondary breast reconstruction after radiotherapy: a case-control 
      study of 45 patients.
PG  - 288-294
LID - 10.28920/dhm51.3.288-294 [doi]
AB  - INTRODUCTION: Radiotherapy reduces the risk of locoregional recurrence of breast 
      cancer. As a side-effect, tissue can become hypocellular, hypovascular, and 
      hypoxic and late radiation tissue injury can develop months or years later. 
      Radiotherapy increases the risk of complications following secondary breast 
      reconstruction. Hyperbaric oxygen treatment (HBOT) improves oxygenation of 
      irradiated tissue and induces neovascularisation. This study evaluated whether 
      the incidence of complications following secondary breast reconstruction after 
      radiotherapy is decreased with perioperative HBOT. METHODS: In this retrospective 
      case-control chart review study, patients who underwent perioperative HBOT (n = 
      15) were compared to lifestyle-matched (n = 15) and radiation damage-matched (n = 
      15) patients who underwent secondary breast reconstruction without HBOT. RESULTS: 
      The HBOT group had significantly more severe radiation damage of the breast than 
      the lifestyle- and radiation-damage-matched control groups (scoring grade 1-4, 
      mean 3.55 versus 1.75 and 2.89 respectively, P = 0.001). Patients underwent on 
      average 33 sessions of HBOT (18 sessions preoperatively and 15 sessions 
      postoperatively). There was no significant difference in the incidence of 
      postoperative complications between the HBOT group, lifestyle-matched group and 
      radiation damage-matched group. Logistic regression analysis showed a lower risk 
      of postoperative complications in patients who underwent HBOT. CONCLUSIONS: 
      Although the HBOT group had more radiation damage than the control groups, the 
      incidence of postoperative complications was not significantly different. This 
      implied a beneficial effect of HBOT, which was supported by the logistic 
      regression analysis. Definitive conclusions cannot be drawn due to the small 
      sample size. Future research is justified, preferably a large randomised 
      controlled trial.
CI  - Copyright: This article is the copyright of the authors who grant Diving and 
      Hyperbaric Medicine a non-exclusive licence to publish the article in electronic 
      and other forms.
FAU - Meier, Eva L
AU  - Meier EL
AD  - Department of Plastic Surgery, Radboud University Medical Center, Nijmegen, The 
      Netherlands.
AD  - Dr Eva Meier, Department of Plastic and Reconstructive Surgery (hp 634), Radboud 
      University Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands, 
      eva.l.meier@radboudumc.nl.
FAU - Hummelink, Stefan
AU  - Hummelink S
AD  - Department of Plastic Surgery, Radboud University Medical Center, Nijmegen, The 
      Netherlands.
FAU - Lansdorp, Nina
AU  - Lansdorp N
AD  - Da Vinci Clinic, Arnhem, The Netherlands.
FAU - Boonstra, Onno
AU  - Boonstra O
AD  - Da Vinci Clinic, Arnhem, The Netherlands.
FAU - Ulrich, Dietmar Jo
AU  - Ulrich DJ
AD  - Department of Plastic Surgery, Radboud University Medical Center, Nijmegen, The 
      Netherlands.
LA  - eng
PT  - Journal Article
PL  - Australia
TA  - Diving Hyperb Med
JT  - Diving and hyperbaric medicine
JID - 101282742
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - *Breast Neoplasms/radiotherapy/surgery
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - *Hyperbaric Oxygenation
MH  - *Mammaplasty
MH  - Oxygen
MH  - Postoperative Complications/etiology/therapy
MH  - Retrospective Studies
PMC - PMC8608449
OTO - NOTNLM
OT  - Cancer
OT  - Hyperbaric research
OT  - Outcome
OT  - Soft tissue radionecrosis
OT  - Surgery
OT  - Women
COIS- Conflict of interest and funding: nil
EDAT- 2021/09/22 06:00
MHDA- 2021/09/24 06:00
PMCR- 2022/09/30
CRDT- 2021/09/21 20:33
PHST- 2021/03/04 00:00 [received]
PHST- 2021/05/20 00:00 [accepted]
PHST- 2021/09/21 20:33 [entrez]
PHST- 2021/09/22 06:00 [pubmed]
PHST- 2021/09/24 06:00 [medline]
PHST- 2022/09/30 00:00 [pmc-release]
AID - 10.28920/dhm51.3.288-294 [doi]
PST - ppublish
SO  - Diving Hyperb Med. 2021 Sep 30;51(3):288-294. doi: 10.28920/dhm51.3.288-294.