PMID- 34549397
OWN - NLM
STAT- MEDLINE
DCOM- 20230911
LR  - 20230911
IS  - 1028-768X (Print)
IS  - 1028-768X (Linking)
VI  - 30(1)
DP  - 2021 Mar
TI  - Human Herpes Virus 6 Encephalitis Presenting as Fatal Refractory Status 
      Epilepticus: a Case Report and Systematic Review.
PG  - 21-26
AB  - PURPOSE: Encephalitis secondary to human herpesvirus 6 (HHV-6) infection is 
      frequently encountered in immunocompromised patients; in contrast, HHV-6 
      encephalitis in immunocompetent patients is rare. There are only 3 reports of 
      status epilepticus due to HHV-6 encephalitis in immunocompetent adults. In the 
      present study, a case of refractory status epilepticus secondary to HHV-6 
      encephalitis was reported in an immunocompetent female. CASE REPORT: We report a 
      case of a previously healthy 46-year-old female who presented with a one-week 
      history of back pain, fever and generalized tonic-clonic seizures that progressed 
      to status epilepticus. The video electroencephalography showed epileptiform 
      discharges on both frontotemporal regions. Neuroimaging showed hyperintensities 
      on the bilateral insula and temporal lobes. The cerebrospinal fluid showed 
      elevated pressure and was positive for HHV-6. She was given ganciclovir and a 
      total of eleven antiepileptic drugs. Despite these medications, she developed 
      refractory status epilepticus and eventually succumbed due to multiple medical 
      complications. CONCLUSION: This case highlights HHV-6 encephalitis as an 
      important diagnostic consideration in patients presenting with refractory status 
      epilepticus, regardless of immune status.
FAU - Ocampo, Ferron F
AU  - Ocampo FF
AD  - Department of 1Institute for Neurosciences, St. Luke's Medical Center, Quezon 
      City and Global City, Philippines.
FAU - Tipones, Rommel N
AU  - Tipones RN
AD  - Department of Internal Medicine, St. Luke's Medical Center, Global City, 
      Philippines.
FAU - Jamora, Roland Dominic G
AU  - Jamora RDG
AD  - Department of 1Institute for Neurosciences, St. Luke's Medical Center, Quezon 
      City and Global City, Philippines.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Systematic Review
PL  - China (Republic : 1949- )
TA  - Acta Neurol Taiwan
JT  - Acta neurologica Taiwanica
JID - 9815355
RN  - 0 (Anticonvulsants)
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Middle Aged
MH  - Anticonvulsants/therapeutic use
MH  - *Encephalitis
MH  - *Encephalitis, Viral/complications/drug therapy
MH  - *Herpesvirus 6, Human
MH  - *Status Epilepticus/drug therapy/etiology
OTO - NOTNLM
OT  - HHV-6 encephalitis; refractory status epilepticus; viral encephalitis.
EDAT- 2021/09/23 06:00
MHDA- 2021/09/24 06:00
CRDT- 2021/09/22 07:20
PHST- 2021/09/22 07:20 [entrez]
PHST- 2021/09/23 06:00 [pubmed]
PHST- 2021/09/24 06:00 [medline]
AID - 10196099/301021 [pii]
PST - ppublish
SO  - Acta Neurol Taiwan. 2021 Mar;30(1):21-26.